Infusion of vasoactive intestinal polypeptide in man: pharmacokinetics and effect on gastric acid secretion.

Holm-Bentzen M, Christiansen J, Petersen B, Fahrenkrug J, Schultz A, Kirkegaard P

Scandinavian journal of gastroenterology1 Apr 1981Cited by 16 (Europe PMC)

PMID16435487DOI10.3109/00365528109181992PepBankPUB-16435487

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

01HumanNon-randomized trialPharmacokinetics
In six healthy volunteers, mean plasma VIP concentration rose from 5.7 pmol/l to 28, 106 and 336 pmol/l during the three stepwise VIP infusions.
In plain wordsIn six healthy adults, blood VIP levels rose with each step of the VIP infusion.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreasePlasma VIP concentration during infusion
Study
n = 6
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
0.5, 0.9 and 2.7 micro/g/kg-h · intravenous · 1 h per doseAs given in this study (human).
Measurements
Plasma VIP, baseline
5.7 pmol/l
before infusion
Plasma VIP
28 pmol/l
first dose
Plasma VIP
106 pmol/l
second dose
Plasma VIP
336 pmol/l
third dose
Source sentences
Summary
Mean plasma VIP concentrations rose from 5.7 pmol/l to 28, 106 and 336 pmol/l during the VIP infusions.
2 context sentences(design, population, supporting numbers)
Summary · context
Elimination and effect on acid secretion of vasoactive intestinal polypeptide (VIP) were studied in six healthy volunteers.
Summary · context
On a background infusion of pentagastrin, 100 ng/kg-h, VIP was administered as stepwise intravenous infusions in doses of 0.5, 0.9, and 2.7 micro/g/kg-h, each dose being give for 1 h.
Report a problemFND-1643548701
02HumanNon-randomized trialEfficacy outcome
In six healthy volunteers, VIP infusion did not significantly change pentagastrin-stimulated gastric acid secretion compared with pentagastrin alone, and no duodeno-gastric reflux was registered.
In plain wordsIn six healthy adults, VIP did not change stomach acid secretion compared with pentagastrin alone.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeGastric acid secretion
Study
n = 6
Comparator
Pentagastrin infusion alone
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
0.5, 0.9 and 2.7 micro/g/kg-h · intravenous · 1 h per doseAs given in this study (human).
Source sentences
Summary
No significant changes in acid secretion occurred during VIP infusion as compared to infusion of pentagastrin alone, and no duodeno-gastric reflux was registered.
2 context sentences(design, population, supporting numbers)
Summary · context
Elimination and effect on acid secretion of vasoactive intestinal polypeptide (VIP) were studied in six healthy volunteers.
Summary · context
On a background infusion of pentagastrin, 100 ng/kg-h, VIP was administered as stepwise intravenous infusions in doses of 0.5, 0.9, and 2.7 micro/g/kg-h, each dose being give for 1 h.
Report a problemFND-1643548702
03HumanNon-randomized trialEfficacy outcome
In six healthy volunteers, serum gastrin concentrations were unaltered during VIP infusion.
In plain wordsIn six healthy adults, VIP infusion did not change blood gastrin levels.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeSerum gastrin concentration
Study
n = 6
Outcome group
Endogenous peptide levels · Gastrointestinal
Studied dose
0.5, 0.9 and 2.7 micro/g/kg-h · intravenous · 1 h per doseAs given in this study (human).
Source sentences
Summary
Serum gastrin concentrations were unaltered during VIP infusion.
2 context sentences(design, population, supporting numbers)
Summary · context
Elimination and effect on acid secretion of vasoactive intestinal polypeptide (VIP) were studied in six healthy volunteers.
Summary · context
On a background infusion of pentagastrin, 100 ng/kg-h, VIP was administered as stepwise intravenous infusions in doses of 0.5, 0.9, and 2.7 micro/g/kg-h, each dose being give for 1 h.
Report a problemFND-1643548703
04HumanNon-randomized trialPharmacokinetics
In six healthy volunteers, VIP elimination was bi-exponential with half-lives of 2 and 21 min.
In plain wordsIn six healthy adults, VIP left the blood in two phases, with half-lives of 2 and 21 minutes.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableVIP elimination half-lives
Study
n = 6
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
0.5, 0.9 and 2.7 micro/g/kg-h · intravenous · 1 h per doseAs given in this study (human).
Measurements
Half-life, first phase
2 min
VIP elimination
Half-life, second phase
21 min
VIP elimination
Source sentences
Summary
Elimination of VIP was bi-exponential with half-lives of 2 and 21 min, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
Elimination and effect on acid secretion of vasoactive intestinal polypeptide (VIP) were studied in six healthy volunteers.
Summary · context
On a background infusion of pentagastrin, 100 ng/kg-h, VIP was administered as stepwise intravenous infusions in doses of 0.5, 0.9, and 2.7 micro/g/kg-h, each dose being give for 1 h.
Report a problemFND-1643548704
05HumanNon-randomized trialPharmacokinetics
In six healthy volunteers, VIP metabolic clearance rate was 42 ml/kg-min and the estimated volume of distribution was 135 ml/kg.
In plain wordsIn six healthy adults, the body cleared VIP at 42 ml/kg per minute, with a distribution volume of 135 ml/kg.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableVIP metabolic clearance rate and volume of distribution
Study
n = 6
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
0.5, 0.9 and 2.7 micro/g/kg-h · intravenous · 1 h per doseAs given in this study (human).
Measurements
Metabolic clearance rate
42 ml/kg-min
VIP
Volume of distribution
135 ml/kg
VIP
Source sentences
Summary
Metabolic clearance rate was 42 ml/kg-min and the estimated volume of distribution 135 ml/kg.
2 context sentences(design, population, supporting numbers)
Summary · context
Elimination and effect on acid secretion of vasoactive intestinal polypeptide (VIP) were studied in six healthy volunteers.
Summary · context
On a background infusion of pentagastrin, 100 ng/kg-h, VIP was administered as stepwise intravenous infusions in doses of 0.5, 0.9, and 2.7 micro/g/kg-h, each dose being give for 1 h.
Report a problemFND-1643548705

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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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