Through the central V2, not V1 receptors influencing the endogenous opiate peptide system, arginine vasopressin, not oxytocin in the hypothalamic paraventricular nucleus involves in the antinociception in the rat.

Yang J, Chen JM, Song CY, Liu WY, Wang G, Wang CH, Lin BC

Brain research10 Jan 2006Cited by 40 (Europe PMC)

PMID16409991DOI10.1016/j.brainres.2005.11.045PepBankPUB-16409991

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Mechanism
In rats, pain stimulation raised arginine vasopressin but not oxytocin concentrations in paraventricular nucleus tissue.
In plain wordsIn rats, pain raised the body's own vasopressin but not the body's own oxytocin in a brain area that controls pain.
Peptide
Oxytocin
Outcome
No significant changeOxytocin concentration in PVN tissue after pain stimulation
Study
ratn: not reported in source
in vivo, hypothalamic paraventricular nucleus
Outcome group
Pain · Nervous system and cognition
Source sentences
Summary
pain stimulation raised the arginine vasopressin (AVP), not oxytocin (OXT), leucine-enkephalin (L-Ek), beta-endorphin (beta-Ep) and DynorphinA1-13 (DynA1-13) concentrations in the PVN tissue using micropunch method
1 context sentence(design, population, supporting numbers)
Summary · context
The central bioactive substances involving in the PVN regulating antinociception were investigated in the rat.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1640999101
02AnimalEndogenous levelAnimal study (in vivo)Mechanism
In rats, pain stimulation did not raise oxytocin concentrations in the paraventricular nucleus perfusion liquid, while vasopressin and opioid peptides rose.
In plain wordsIn rats, pain did not raise the body's own oxytocin released in a brain area, while vasopressin and opioid peptides rose.
Peptide
Oxytocin
Outcome
No significant changeOxytocin concentration in PVN perfusate after pain stimulation
Study
ratn: not reported in source
in vivo, hypothalamic paraventricular nucleus
Outcome group
Pain · Nervous system and cognition
Source sentences
Summary
heightened AVP, L-Ek, beta-Ep and DynA1-13, not OXT concentrations in the PVN perfuse liquid
1 context sentence(design, population, supporting numbers)
Summary · context
The central bioactive substances involving in the PVN regulating antinociception were investigated in the rat.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1640999102
03AnimalEndogenous levelAnimal study (in vivo)Mechanism
In rats, pain stimulation reduced the number of vasopressin-immunoreactive neurons but not oxytocin-immunoreactive neurons in the paraventricular nucleus.
In plain wordsIn rats, pain reduced the number of vasopressin-stained brain cells but did not change the number of cells with the body's own oxytocin.
Peptide
Oxytocin
Outcome
No significant changeOxytocin-immunoreactive neuron number in PVN after pain stimulation
Study
ratn: not reported in source
in vivo, hypothalamic paraventricular nucleus
Outcome group
Pain · Nervous system and cognition
Source sentences
Summary
reduced the number of AVP-, not OXT, L-Ek, beta-Ep and DynA1-13-immunoreactive neurons in the PVN especially in the posterior magnocellular part of the PVN using immunocytochemistry
1 context sentence(design, population, supporting numbers)
Summary · context
The central bioactive substances involving in the PVN regulating antinociception were investigated in the rat.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1640999103
04AnimalEndogenous levelAnimal study (in vivo)Mechanism
In rats, pain stimulation enhanced vasopressin mRNA expression but not oxytocin mRNA expression in the paraventricular nucleus.
In plain wordsIn rats, pain raised vasopressin gene activity but not the body's own oxytocin gene activity in a brain area.
Peptide
Oxytocin
Outcome
No significant changeOxytocin mRNA expression in PVN after pain stimulation
Study
ratn: not reported in source
in vivo, hypothalamic paraventricular nucleus
Outcome group
Pain · Nervous system and cognition
Source sentences
Summary
pain stimulation enhanced the AVP, not OXT mRNA expression in the PVN using in situ hybridization and RT-PCR
1 context sentence(design, population, supporting numbers)
Summary · context
The central bioactive substances involving in the PVN regulating antinociception were investigated in the rat.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1640999104

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

05AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In rats, anti-oxytocin serum given before L-glutamate injection into the paraventricular nucleus did not change the induced antinociception, while anti-vasopressin serum reversed it.
In plain wordsIn rats, blocking the body's own oxytocin did not change glutamate-induced pain relief, while blocking vasopressin reversed it.
Peptide
Oxytocin
Outcome
No significant changeL-glutamate-induced antinociception after anti-oxytocin serum
Study
ratn: not reported in source
in vivo, hypothalamic paraventricular nucleus
Outcome group
Pain · Nervous system and cognition
Source sentences
Summary
but anti-OXT serum pretreatment did not influence this L-glutamate sodium effect
1 context sentence(design, population, supporting numbers)
Summary · context
The central bioactive substances involving in the PVN regulating antinociception were investigated in the rat.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1640999105

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:52 UTC
First added · source update from Europe PMC

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