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Study · Animal study (in vivo) · rodent · 2005

6 results

Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents.

Eremin KO, Kudrin VS, Saransaari P, Oja SS, Grivennikov IA, Myasoedov NF, Rayevsky KS

Neurochemical research1 Dec 2005Cited by 18 (Europe PMC)

PMID16362768 (opens in a new tab)DOI10.1007/s11064-005-8826-8 (opens in a new tab)PepBankPUB-16362768
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rodents, striatal tissue content of 5-HIAA was significantly increased 2 h after Semax administration.

    In plain wordsIn rodents, the tissue level of a serotonin breakdown product (5-HIAA) in the striatum rose 25% two hours after Semax.

    Peptide
    Semax
    Outcome
    IncreaseStriatal tissue content of 5-HIAA
    Study

    rodentn: not reported in source

    In vivo
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    5-HIAA tissue content change
    25%
    striatum, 2 h after Semax

    Source sentences

    Summary
    The tissue content of 5-hydroxyindoleacetic acid (5-HIAA) in the striatum was significantly increased (+25%) 2 h after Semax administration.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rodents, extracellular striatal 5-HIAA gradually increased up to 180% within 1-4 h after Semax.

    In plain wordsIn rodents, Semax raised the outside-cell level of a serotonin breakdown product (5-HIAA) in the striatum up to 180% within 1 to 4 hours.

    Peptide
    Semax
    Outcome
    IncreaseExtracellular striatal 5-HIAA level
    Study

    rodentn: not reported in source

    In vivo
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    0.15 mg/kg · intraperitonealAs given in this study (rodent).

    Measurements

    Extracellular 5-HIAA
    180%
    striatum, 1-4 h after Semax

    Source sentences

    Summary
    The extracellular striatal level of 5-HIAA gradually increased up to 180% within 1-4 h after Semax (0.15 mg/kg, ip) administration.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rodents, Semax alone did not alter tissue concentrations of dopamine and its metabolites.

    In plain wordsIn rodents, Semax alone did not change tissue levels of dopamine or its breakdown products.

    Peptide
    Semax
    Outcome
    No significant changeStriatal tissue dopamine and metabolites
    Study

    rodentn: not reported in source

    In vivo
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This peptide alone failed to alter the tissue and extracellular concentrations of dopamine and its metabolites.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rodents, Semax alone did not alter extracellular concentrations of dopamine and its metabolites.

    In plain wordsIn rodents, Semax alone did not change outside-cell levels of dopamine or its breakdown products.

    Peptide
    Semax
    Outcome
    No significant changeExtracellular striatal dopamine and metabolites
    Study

    rodentn: not reported in source

    In vivo
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This peptide alone failed to alter the tissue and extracellular concentrations of dopamine and its metabolites.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rodents, Semax injected 20 min before D-amphetamine strongly enhanced the effect of D-amphetamine on extracellular dopamine.

    In plain wordsIn rodents, Semax given before amphetamine increased the amphetamine-induced rise in dopamine, compared with amphetamine alone.

    Peptide
    Semax
    Outcome
    IncreaseD-amphetamine effect on extracellular dopamine
    Study

    rodentn: not reported in source

    In vivo
    Comparator
    D-amphetamine alone
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Semax injected 20 min prior D: -amphetamine dramatically enhanced the effects of the latter on the extracellular level of dopamine and on the locomotor activity of animals.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rodents, Semax injected 20 min before D-amphetamine strongly enhanced the effect of D-amphetamine on locomotor activity.

    In plain wordsIn rodents, Semax given before amphetamine increased the amphetamine-induced movement, compared with amphetamine alone.

    Peptide
    Semax
    Outcome
    IncreaseD-amphetamine effect on locomotor activity
    Study

    rodentn: not reported in source

    In vivo
    Comparator
    D-amphetamine alone
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Semax injected 20 min prior D: -amphetamine dramatically enhanced the effects of the latter on the extracellular level of dopamine and on the locomotor activity of animals.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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