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Study · In vitro (cells) · 2006

7 results

Neuroprotection of cerebrolysin in tissue culture models of brain ischemia: post lesion application indicates a wide therapeutic window.

Schauer E, Wronski R, Patockova J, Moessler H, Doppler E, Hutter-Paier B, Windisch M

Journal of neural transmission (Vienna, Austria : 1996)14 Dec 2005Cited by 29 (Europe PMC)

PMID16362636 (opens in a new tab)DOI10.1007/s00702-005-0384-3 (opens in a new tab)PepBankPUB-16362636
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In glutamate-lesioned tissue cultures, acute and delayed Cerebrolysin treatment significantly rescued neurons in a dose-dependent manner.

    In plain wordsIn lab tests, acute and delayed Cerebrolysin treatment increased neuron survival after glutamate injury.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNeuronal survival after acute and delayed treatment
    Study

    n: not reported in source

    Glutamate excitotoxic tissue culture
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After both types of lesion, acute as well as delayed treatment with Cere resulted in a dose dependent and significant rescue of neurons.
    1 context sentence
    Summary · context
    In this study 2 different tissue culture models of ischemia, excitotoxic lesion by the use of glutamate and oxygen-glucose deprivation (OGD), were used to investigate the effects of delayed application of Cerebrolysin (Cere) on neuronal survival.
  2. 02LabIn vitro (cells)Efficacy outcome

    In oxygen-glucose-deprived tissue cultures, acute and delayed Cerebrolysin treatment significantly rescued neurons in a dose-dependent manner.

    In plain wordsIn lab tests, acute and delayed Cerebrolysin treatment increased neuron survival after oxygen-glucose deprivation.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNeuronal survival after acute and delayed treatment
    Study

    n: not reported in source

    Oxygen-glucose deprivation tissue culture
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After both types of lesion, acute as well as delayed treatment with Cere resulted in a dose dependent and significant rescue of neurons.
    1 context sentence
    Summary · context
    In this study 2 different tissue culture models of ischemia, excitotoxic lesion by the use of glutamate and oxygen-glucose deprivation (OGD), were used to investigate the effects of delayed application of Cerebrolysin (Cere) on neuronal survival.
  3. 03LabIn vitro (cells)Efficacy outcome

    In glutamate-lesioned cultures, Cerebrolysin had significant effects even when treatment began 96 hours after glutamate addition.

    In plain wordsIn lab tests, Cerebrolysin increased neuron survival even when treatment began 96 hours after glutamate injury.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNeuronal rescue with 96-hour delay
    Study

    n: not reported in source

    Glutamate excitotoxic tissue culture
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the model of excitotoxic cell death significant drug effects were found even when the treatment started with a delay of 96 hours after addition of glutamate.
    1 context sentence
    Summary · context
    In this study 2 different tissue culture models of ischemia, excitotoxic lesion by the use of glutamate and oxygen-glucose deprivation (OGD), were used to investigate the effects of delayed application of Cerebrolysin (Cere) on neuronal survival.
  4. 04LabIn vitro (cells)Efficacy outcome

    In oxygen-glucose-deprived cultures, Cerebrolysin produced pronounced neuronal rescue with a 48-hour treatment delay.

    In plain wordsIn lab tests, Cerebrolysin increased neuron survival when treatment began 48 hours after oxygen-glucose deprivation.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNeuronal rescue with 48-hour delay
    Study

    n: not reported in source

    Oxygen-glucose deprivation tissue culture
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the OGD model pronounced effects were found after 48 hours delay of treatment, and even after 72 hours a small but significant rescue of neurons was detected.
    1 context sentence
    Summary · context
    In this study 2 different tissue culture models of ischemia, excitotoxic lesion by the use of glutamate and oxygen-glucose deprivation (OGD), were used to investigate the effects of delayed application of Cerebrolysin (Cere) on neuronal survival.
  5. 05LabIn vitro (cells)Efficacy outcome

    In oxygen-glucose-deprived cultures, Cerebrolysin produced small but significant neuronal rescue with a 72-hour treatment delay.

    In plain wordsIn lab tests, Cerebrolysin slightly increased neuron survival when treatment began 72 hours after oxygen-glucose deprivation.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNeuronal rescue with 72-hour delay
    Study

    n: not reported in source

    Oxygen-glucose deprivation tissue culture
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the OGD model pronounced effects were found after 48 hours delay of treatment, and even after 72 hours a small but significant rescue of neurons was detected.
    1 context sentence
    Summary · context
    In this study 2 different tissue culture models of ischemia, excitotoxic lesion by the use of glutamate and oxygen-glucose deprivation (OGD), were used to investigate the effects of delayed application of Cerebrolysin (Cere) on neuronal survival.
  6. 06LabIn vitro (cells)Efficacy outcome

    In tissue cultures, a single Cerebrolysin addition significantly protected neurons until experiment completion, up to 2 weeks after lesioning.

    In plain wordsIn lab tests, one Cerebrolysin addition protected neurons for up to 2 weeks after injury.

    Peptide
    Cerebrolysin
    Outcome
    IncreasePersistence of neuroprotection
    Study

    n: not reported in source

    Ischemia tissue culture models
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The neuroprotective effects of a single addition of Cerebrolysin to the culture medium resulted in significant protection until end of the experiments which was up to 2 weeks after the initial lesion.
    1 context sentence
    Summary · context
    In this study 2 different tissue culture models of ischemia, excitotoxic lesion by the use of glutamate and oxygen-glucose deprivation (OGD), were used to investigate the effects of delayed application of Cerebrolysin (Cere) on neuronal survival.
  7. 07LabIn vitro (cells)Activity measurement

    In tissue cultures, efficacious Cerebrolysin dosages shifted from low to high concentrations.

    In plain wordsIn lab tests, effective Cerebrolysin concentrations shifted from low to high.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseEfficacious concentration shift
    Study

    n: not reported in source

    Ischemia tissue culture models
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A shift of the efficacious dosages from low to high concentrations
    1 context sentence
    Summary · context
    In this study 2 different tissue culture models of ischemia, excitotoxic lesion by the use of glutamate and oxygen-glucose deprivation (OGD), were used to investigate the effects of delayed application of Cerebrolysin (Cere) on neuronal survival.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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