Leuprolide acetate suppresses pedophilic urges and arousability.

Schober JM, Kuhn PJ, Kovacs PG, Earle JH, Byrne PM, Fries RA

Archives of sexual behavior1 Dec 2005Cited by 44 (Europe PMC)

PMID16362253DOI10.1007/s10508-005-7929-2PepBankPUB-16362253

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

01HumanNon-randomized trialActivity measurement
In men with pedophilia receiving psychotherapy, testosterone decreased to castrate levels during leuprolide treatment.
In plain wordsTestosterone fell to castrate levels during leuprolide treatment in men with pedophilia receiving psychotherapy.
Peptide
Leuprolide
Outcome
DecreaseTestosterone
Study
n = 5
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · depot injection · 12 monthsAs given in this study (human).
Source sentences
Summary
On LA, testosterone decreased to castrate levels.
2 context sentences(design, population, supporting numbers)
Summary · context
Cognitive-behavioral psychotherapy was compared with cognitive-behavioral psychotherapy augmented by leuprolide acetate (LA) for suppression of pedophilic behavior.
Summary · context
Five male pedophiles (M age, 50 years; range, 36-58) were administered LA by Depo injection for 12 months, followed by saline placebo for 12 months.
Report a problemFND-1636225301
02HumanNon-randomized trialEfficacy outcome
In men with pedophilia receiving psychotherapy, leuprolide significantly suppressed penile tumescence compared with baseline, but responses still detected pedophilic interest.
In plain wordsLeuprolide reduced penile responses versus baseline in men with pedophilia receiving psychotherapy, but responses still showed pedophilic interest.
Peptide
Leuprolide
Outcome
DecreasePenile tumescence
Study
n = 5
Comparator
Baseline
Outcome group
Sexual function · Reproductive and sexual health
Studied dose
Dose not stated · depot injection · 12 monthsAs given in this study (human).
Source sentences
Summary
Penile tumescence was significantly suppressed compared with baseline, but sufficient response remained to detect pedophilic interest.
2 context sentences(design, population, supporting numbers)
Summary · context
Cognitive-behavioral psychotherapy was compared with cognitive-behavioral psychotherapy augmented by leuprolide acetate (LA) for suppression of pedophilic behavior.
Summary · context
Five male pedophiles (M age, 50 years; range, 36-58) were administered LA by Depo injection for 12 months, followed by saline placebo for 12 months.
Report a problemFND-1636225302
03HumanNon-randomized trialActivity measurement
In men with pedophilia receiving psychotherapy and leuprolide, visual reaction times still detected pedophilic interest.
In plain wordsVisual reaction times still showed pedophilic interest in men receiving psychotherapy and leuprolide.
Peptide
Leuprolide
Outcome
Not applicablePedophilic interest detection by visual reaction time
Study
n = 5
Outcome group
Sexual function · Reproductive and sexual health
Studied dose
Dose not stated · depot injection · 12 monthsAs given in this study (human).
Source sentences
Summary
Pedophilic interest was also detected by visual reaction times.
2 context sentences(design, population, supporting numbers)
Summary · context
Cognitive-behavioral psychotherapy was compared with cognitive-behavioral psychotherapy augmented by leuprolide acetate (LA) for suppression of pedophilic behavior.
Summary · context
Five male pedophiles (M age, 50 years; range, 36-58) were administered LA by Depo injection for 12 months, followed by saline placebo for 12 months.
Report a problemFND-1636225303
04HumanNon-randomized trialEfficacy outcome
In men with pedophilia receiving psychotherapy, all subjects reported decreased pedophilic urges during leuprolide treatment.
In plain wordsAll men reported fewer pedophilic urges during leuprolide treatment with psychotherapy.
Peptide
Leuprolide
Outcome
DecreaseSelf-reported pedophilic urges
Study
n = 5
Outcome group
Sexual function · Reproductive and sexual health
Studied dose
Dose not stated · depot injection · 12 monthsAs given in this study (human).
Source sentences
Summary
When asked about having pedophilic urges and masturbating to thoughts of children, all subjects self-reported a decrease.
2 context sentences(design, population, supporting numbers)
Summary · context
Cognitive-behavioral psychotherapy was compared with cognitive-behavioral psychotherapy augmented by leuprolide acetate (LA) for suppression of pedophilic behavior.
Summary · context
Five male pedophiles (M age, 50 years; range, 36-58) were administered LA by Depo injection for 12 months, followed by saline placebo for 12 months.
Report a problemFND-1636225304
05HumanNon-randomized trialEfficacy outcome
In men with pedophilia receiving psychotherapy, all subjects reported decreased masturbation involving thoughts of children during leuprolide treatment.
In plain wordsAll men reported less masturbation involving thoughts of children during leuprolide treatment with psychotherapy.
Peptide
Leuprolide
Outcome
DecreaseSelf-reported masturbation involving thoughts of children
Study
n = 5
Outcome group
Sexual function · Reproductive and sexual health
Studied dose
Dose not stated · depot injection · 12 monthsAs given in this study (human).
Source sentences
Summary
When asked about having pedophilic urges and masturbating to thoughts of children, all subjects self-reported a decrease.
2 context sentences(design, population, supporting numbers)
Summary · context
Cognitive-behavioral psychotherapy was compared with cognitive-behavioral psychotherapy augmented by leuprolide acetate (LA) for suppression of pedophilic behavior.
Summary · context
Five male pedophiles (M age, 50 years; range, 36-58) were administered LA by Depo injection for 12 months, followed by saline placebo for 12 months.
Report a problemFND-1636225305
06HumanNon-randomized trialActivity measurement
In men with pedophilia receiving psychotherapy and leuprolide, polygraph responses indicated that subjects were not deceptive.
In plain wordsPolygraph responses indicated no deception in men receiving psychotherapy and leuprolide.
Peptide
Leuprolide
Outcome
Not applicablePolygraph responses during treatment
Study
n = 5
Outcome group
Sexual function · Reproductive and sexual health
Studied dose
Dose not stated · depot injection · 12 monthsAs given in this study (human).
Source sentences
Summary
Polygraph responses indicated subjects were not deceptive.
2 context sentences(design, population, supporting numbers)
Summary · context
Cognitive-behavioral psychotherapy was compared with cognitive-behavioral psychotherapy augmented by leuprolide acetate (LA) for suppression of pedophilic behavior.
Summary · context
Five male pedophiles (M age, 50 years; range, 36-58) were administered LA by Depo injection for 12 months, followed by saline placebo for 12 months.
Report a problemFND-1636225306
07HumanNon-randomized trialEfficacy outcome
In men with pedophilia receiving psychotherapy, interest preference measured by Abel Assessment and Monarch PPG remained generally unchanged during leuprolide treatment.
In plain wordsMeasured sexual interest preference remained generally unchanged during leuprolide treatment with psychotherapy in men with pedophilia.
Peptide
Leuprolide
Outcome
No significant changeInterest preference
Study
n = 5
Outcome group
Sexual function · Reproductive and sexual health
Studied dose
Dose not stated · depot injection · 12 monthsAs given in this study (human).
Source sentences
Summary
Interest preference, as measured by Abel Assessment and Monarch PPG, was generally unchanged throughout the study.
2 context sentences(design, population, supporting numbers)
Summary · context
Cognitive-behavioral psychotherapy was compared with cognitive-behavioral psychotherapy augmented by leuprolide acetate (LA) for suppression of pedophilic behavior.
Summary · context
Five male pedophiles (M age, 50 years; range, 36-58) were administered LA by Depo injection for 12 months, followed by saline placebo for 12 months.
Report a problemFND-1636225307

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:37 UTC
First added · source update from Europe PMC

Subjects

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