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Study · Non-randomized trial · n = 25 · 2006

7 results

Aging attenuates both the regularity and joint synchrony of LH and testosterone secretion in normal men: analyses via a model of graded GnRH receptor blockade.

Liu PY, Pincus SM, Takahashi PY, Roebuck PD, Iranmanesh A, Keenan DM, Veldhuis JD

American journal of physiology. Endocrinology and metabolism1 Jan 2006Cited by 22 (Europe PMC)

PMID16339924 (opens in a new tab)DOI10.1152/ajpendo.00227.2005 (opens in a new tab)PepBankPUB-16339924
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

  1. 01HumanNon-randomized trialMechanism

    In healthy men, graded GnRH blockade with ganirelix increased LH secretion regularity across the cohort (P<0.001).

    In plain wordsIn healthy men, graded ganirelix blockade increased LH secretion regularity compared with placebo.

    Peptide
    Ganirelix
    Outcome
    IncreaseLH secretion regularity
    Study

    n = 25

    Comparator
    placebo and graded blockade conditions
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Graded blockade of GnRH drive increased the individual regularity of LH and T secretion and the synchrony of LH-T feedforward and T-LH feedback in the cohort as a whole (P<0.001 for each).
    1 context sentence
    Summary · context
    Analyses comprised 100 paired 18-h LH and T concentration time series obtained in 25 healthy men ages 20-72 yr each administered placebo and three graded doses of a specific GnRH-receptor antagonist.
  2. 02HumanNon-randomized trialMechanism

    In healthy men, graded GnRH blockade with ganirelix increased testosterone secretion regularity across the cohort (P<0.001).

    In plain wordsIn healthy men, graded ganirelix blockade increased testosterone secretion regularity compared with placebo.

    Peptide
    Ganirelix
    Outcome
    IncreaseTestosterone secretion regularity
    Study

    n = 25

    Comparator
    placebo and graded blockade conditions
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Graded blockade of GnRH drive increased the individual regularity of LH and T secretion and the synchrony of LH-T feedforward and T-LH feedback in the cohort as a whole (P<0.001 for each).
    1 context sentence
    Summary · context
    Analyses comprised 100 paired 18-h LH and T concentration time series obtained in 25 healthy men ages 20-72 yr each administered placebo and three graded doses of a specific GnRH-receptor antagonist.
  3. 03HumanNon-randomized trialMechanism

    In healthy men, graded GnRH blockade with ganirelix increased LH-T feedforward synchrony (P<0.001).

    In plain wordsIn healthy men, graded ganirelix blockade increased LH-T feedforward synchrony compared with placebo.

    Peptide
    Ganirelix
    Outcome
    IncreaseLH-T feedforward synchrony
    Study

    n = 25

    Comparator
    placebo and graded blockade conditions
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Graded blockade of GnRH drive increased the individual regularity of LH and T secretion and the synchrony of LH-T feedforward and T-LH feedback in the cohort as a whole (P<0.001 for each).
    1 context sentence
    Summary · context
    Analyses comprised 100 paired 18-h LH and T concentration time series obtained in 25 healthy men ages 20-72 yr each administered placebo and three graded doses of a specific GnRH-receptor antagonist.
  4. 04HumanNon-randomized trialMechanism

    In healthy men, graded GnRH blockade with ganirelix increased T-LH feedback synchrony (P<0.001).

    In plain wordsIn healthy men, graded ganirelix blockade increased T-LH feedback synchrony compared with placebo.

    Peptide
    Ganirelix
    Outcome
    IncreaseT-LH feedback synchrony
    Study

    n = 25

    Comparator
    placebo and graded blockade conditions
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Graded blockade of GnRH drive increased the individual regularity of LH and T secretion and the synchrony of LH-T feedforward and T-LH feedback in the cohort as a whole (P<0.001 for each).
    1 context sentence
    Summary · context
    Analyses comprised 100 paired 18-h LH and T concentration time series obtained in 25 healthy men ages 20-72 yr each administered placebo and three graded doses of a specific GnRH-receptor antagonist.
  5. 05HumanNon-randomized trialMechanism

    In healthy men, age attenuated ganirelix-induced enhancement of testosterone secretion orderliness (P <or= 0.0025).

    In plain wordsIn healthy men, older age reduced the enhancement of testosterone secretion orderliness with ganirelix compared with younger age.

    Peptide
    Ganirelix
    Outcome
    DecreaseAge attenuation of testosterone orderliness response
    Study

    n = 25

    Comparator
    younger age
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, age markedly attenuated ganirelix-induced enhancement of univariate T orderliness and bivariate LH-T feedback and T-LH feedback synchrony (P <or= 0.0025).
    1 context sentence
    Summary · context
    Analyses comprised 100 paired 18-h LH and T concentration time series obtained in 25 healthy men ages 20-72 yr each administered placebo and three graded doses of a specific GnRH-receptor antagonist.
  6. 06HumanNon-randomized trialMechanism

    In healthy men, age attenuated ganirelix-induced enhancement of LH-T feedback synchrony (P <or= 0.0025).

    In plain wordsIn healthy men, older age reduced the enhancement of LH-T feedback synchrony with ganirelix compared with younger age.

    Peptide
    Ganirelix
    Outcome
    DecreaseAge attenuation of LH-T feedback synchrony response
    Study

    n = 25

    Comparator
    younger age
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, age markedly attenuated ganirelix-induced enhancement of univariate T orderliness and bivariate LH-T feedback and T-LH feedback synchrony (P <or= 0.0025).
    1 context sentence
    Summary · context
    Analyses comprised 100 paired 18-h LH and T concentration time series obtained in 25 healthy men ages 20-72 yr each administered placebo and three graded doses of a specific GnRH-receptor antagonist.
  7. 07HumanNon-randomized trialMechanism

    In healthy men, age attenuated ganirelix-induced enhancement of T-LH feedback synchrony (P <or= 0.0025).

    In plain wordsIn healthy men, older age reduced the enhancement of T-LH feedback synchrony with ganirelix compared with younger age.

    Peptide
    Ganirelix
    Outcome
    DecreaseAge attenuation of T-LH feedback synchrony response
    Study

    n = 25

    Comparator
    younger age
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, age markedly attenuated ganirelix-induced enhancement of univariate T orderliness and bivariate LH-T feedback and T-LH feedback synchrony (P <or= 0.0025).
    1 context sentence
    Summary · context
    Analyses comprised 100 paired 18-h LH and T concentration time series obtained in 25 healthy men ages 20-72 yr each administered placebo and three graded doses of a specific GnRH-receptor antagonist.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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