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Study · Not a test of the peptide alone · 2005

3 results

Central oxytocin, vasopressin, and corticotropin-releasing factor receptor densities in the basal forebrain predict isolation potentiated startle in rats.

Nair HP, Gutman AR, Davis M, Young LJ

The Journal of neuroscience : the official journal of the Society for Neuroscience1 Dec 2005Cited by 30 (Europe PMC)

PMID16339041 (opens in a new tab)PMCIDPMC6725901 (opens in a new tab)DOI10.1523/jneurosci.2524-05.2005 (opens in a new tab)PepBankPUB-16339041
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In rats, oxytocin receptor binding in the intermediate zone of the lateral septum covaried with isolation potentiated startle.

    In plain wordsIn rats, the amount of oxytocin receptor in one brain area was linked to how strongly the rats startled after isolation.

    Peptide
    Oxytocin
    Outcome
    Not applicableOxytocin receptor binding in lateral septum and isolation potentiated startle
    Study

    ratn: not reported in source

    Outcome group
    Anxiety and mood · Mental health and mood

    Source sentences

    Summary
    Partial least squares (PLS) analysis identified three binding sites, the shell of the nucleus accumbens (AccSh), lateral bed nucleus of the stria terminalis, and intermediate zone of the lateral septum, in which CRF1, V1aR, and OTR receptors, respectively, covaried with IPS.
    1 context sentence
    Summary · context
    Here, we explored this issue by using a multivariate approach to identify brain sites in which oxytocin (OTR), vasopressin (V1aR), and corticotropin-releasing factor type 1 (CRF1) or type 2 receptor binding covaried with a measure of isolation-induced anxiety: isolation potentiated startle (IPS).

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In rats, a linear combination of CRF1, V1aR and oxytocin receptor binding at three sites predicted isolation potentiated startle values in a new group of animals.

    In plain wordsIn rats, receptor levels at three brain sites, including the oxytocin receptor, predicted startle after isolation in new animals.

    Peptide
    Oxytocin
    Outcome
    Not applicablePrediction of isolation potentiated startle by three receptor binding sites in new animals
    Study

    ratn: not reported in source

    Outcome group
    Anxiety and mood · Mental health and mood

    Source sentences

    Summary
    Using the same multiple regression model, the linear combination of the same three binding sites/peptide receptors measured in a new group of animals successfully predicted their IPS values.
    1 context sentence
    Summary · context
    Here, we explored this issue by using a multivariate approach to identify brain sites in which oxytocin (OTR), vasopressin (V1aR), and corticotropin-releasing factor type 1 (CRF1) or type 2 receptor binding covaried with a measure of isolation-induced anxiety: isolation potentiated startle (IPS).

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In rats, receptor binding did not differ between grouped and isolated animals, which suggests trait effects rather than a consequence of isolation.

    In plain wordsIn rats, receptor levels were the same in grouped and isolated animals.

    Peptide
    Oxytocin
    Outcome
    No significant changeReceptor binding in grouped versus isolated animals
    Study

    ratn: not reported in source

    Comparator
    Grouped animals
    Outcome group
    Receptor activity and mechanism · Mental health and mood

    Source sentences

    Summary
    There were no differences in binding between grouped and isolated animals, suggesting that the patterns are trait effects rather than a consequence of isolation.
    1 context sentence
    Summary · context
    Here, we explored this issue by using a multivariate approach to identify brain sites in which oxytocin (OTR), vasopressin (V1aR), and corticotropin-releasing factor type 1 (CRF1) or type 2 receptor binding covaried with a measure of isolation-induced anxiety: isolation potentiated startle (IPS).

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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