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Study · In vitro (cells) · mouse · 2006

7 results

Melanocortin receptor signaling in RAW264.7 macrophage cell line.

Lam CW, Perretti M, Getting SJ

Peptides15 Nov 2005Cited by 33 (Europe PMC)

PMID16293345 (opens in a new tab)DOI10.1016/j.peptides.2005.01.031 (opens in a new tab)PepBankPUB-16293345
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In RAW264.7 macrophage cells, MTII did not alter ERK1/2 phosphorylation.

    In plain wordsIn cells, MTII did not change ERK1/2 phosphorylation in a mouse macrophage line.

    Peptide
    Melanotan II
    Outcome
    No significant changeERK1/2 phosphorylation
    Study

    mousen: not reported in source

    RAW264.7 macrophage cell line
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cell incubation with ACTH(1-39) or MTII (melanotan II) did not alter ERK1/2 and JNK phosphorylation
    1 context sentence
    Summary · context
    Here we have investigated the early cell-signaling pathway responsible for the induction of interleukin-10 (IL-10) in RAW264.7 cells.
  2. 02LabIn vitro (cells)Mechanism

    In RAW264.7 macrophage cells, MTII did not alter JNK phosphorylation.

    In plain wordsIn cells, MTII did not change JNK phosphorylation in a mouse macrophage line.

    Peptide
    Melanotan II
    Outcome
    No significant changeJNK phosphorylation
    Study

    mousen: not reported in source

    RAW264.7 macrophage cell line
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cell incubation with ACTH(1-39) or MTII (melanotan II) did not alter ERK1/2 and JNK phosphorylation
    1 context sentence
    Summary · context
    Here we have investigated the early cell-signaling pathway responsible for the induction of interleukin-10 (IL-10) in RAW264.7 cells.
  3. 03LabIn vitro (cells)Mechanism

    In RAW264.7 macrophage cells, MTII induced p38 phosphorylation within minutes.

    In plain wordsIn cells, MTII raised p38 phosphorylation within minutes in a mouse macrophage line.

    Peptide
    Melanotan II
    Outcome
    Increasep38 phosphorylation
    Study

    mousen: not reported in source

    RAW264.7 macrophage cell line
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cell incubation with ACTH(1-39) or MTII (melanotan II) did not alter ERK1/2 and JNK phosphorylation, while p38 phosphorylation and intracellular cAMP accumulation occurred within minutes.
    1 context sentence
    Summary · context
    Here we have investigated the early cell-signaling pathway responsible for the induction of interleukin-10 (IL-10) in RAW264.7 cells.
  4. 04LabIn vitro (cells)Mechanism

    In RAW264.7 macrophage cells, MTII induced intracellular cAMP accumulation within minutes.

    In plain wordsIn cells, MTII raised cAMP inside a mouse macrophage line within minutes.

    Peptide
    Melanotan II
    Outcome
    IncreaseIntracellular cAMP accumulation
    Study

    mousen: not reported in source

    RAW264.7 macrophage cell line
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cell incubation with ACTH(1-39) or MTII (melanotan II) did not alter ERK1/2 and JNK phosphorylation, while p38 phosphorylation and intracellular cAMP accumulation occurred within minutes.
    1 context sentence
    Summary · context
    Here we have investigated the early cell-signaling pathway responsible for the induction of interleukin-10 (IL-10) in RAW264.7 cells.
  5. 05LabIn vitro (cells)Efficacy outcome

    In RAW264.7 macrophage cells, MTII provoked a time-dependent accumulation of IL-10.

    In plain wordsIn cells, MTII caused IL-10 to build up over time in a mouse macrophage line.

    Peptide
    Melanotan II
    Outcome
    IncreaseIL-10 accumulation
    Study

    mousen: not reported in source

    RAW264.7 macrophage cell line
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    ACTH(1-39) and MTII provoked a time-dependent accumulation of IL-10
    1 context sentence
    Summary · context
    Here we have investigated the early cell-signaling pathway responsible for the induction of interleukin-10 (IL-10) in RAW264.7 cells.
  6. 06LabIn vitro (cells)Mechanism

    In RAW264.7 macrophage cells, the PKA inhibitor H-89 abrogated the IL-10 accumulation induced by MTII.

    In plain wordsIn cells, blocking PKA with H-89 stopped the IL-10 build-up that MTII caused.

    Peptide
    Melanotan II
    Outcome
    Not applicableMTII-induced IL-10 with PKA inhibitor H-89
    Study

    mousen: not reported in source

    RAW264.7 macrophage cell line
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    ACTH(1-39) and MTII provoked a time-dependent accumulation of IL-10 that was abrogated by the PKA inhibitor H-89 and only partially blocked by the p38 MAPK inhibitor SB203580.
    1 context sentence
    Summary · context
    Here we have investigated the early cell-signaling pathway responsible for the induction of interleukin-10 (IL-10) in RAW264.7 cells.
  7. 07LabIn vitro (cells)Mechanism

    In RAW264.7 macrophage cells, the p38 MAPK inhibitor SB203580 only partially blocked the IL-10 accumulation induced by MTII.

    In plain wordsIn cells, blocking p38 with SB203580 only partly reduced the IL-10 build-up that MTII caused.

    Peptide
    Melanotan II
    Outcome
    Not applicableMTII-induced IL-10 with p38 inhibitor SB203580
    Study

    mousen: not reported in source

    RAW264.7 macrophage cell line
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    ACTH(1-39) and MTII provoked a time-dependent accumulation of IL-10 that was abrogated by the PKA inhibitor H-89 and only partially blocked by the p38 MAPK inhibitor SB203580.
    1 context sentence
    Summary · context
    Here we have investigated the early cell-signaling pathway responsible for the induction of interleukin-10 (IL-10) in RAW264.7 cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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