In rats on a low-carbohydrate high-fat diet, the feeding response to intracerebroventricular melanotan II was greater, so these rats were more sensitive to it.
In plain wordsIn rats on a low-carbohydrate, high-fat diet, melanotan II had a stronger effect on feeding.
- Peptide
- Melanotan II
- Outcome
- IncreaseFeeding response to intracerebroventricular melanotan-II
- Study
ratn: not reported in source
rats on a low-carbohydrate high-fat diet- Outcome group
- Appetite and food intake · Metabolic and weight
- Studied dose
- Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
LC-HF rats were more sensitive to melanotan-II and less sensitive to SHU9119.
1 context sentence(design, population, supporting numbers)
After 8 weeks, rats received intracerebroventricular injections of a melanocortin agonist (melanotan-II) and antagonist (SHU9119), and feeding responses were measured.