In bulbectomized mice, noopept restored preference for the platform sector in the Morris test, unlike saline.
In plain wordsIn mice after olfactory bulb removal, noopept improved spatial memory compared with saline.
- Peptide
- Noopept (omberacetam)
- Outcome
- IncreaseSpatial memory
- Study
mousen: not reported in source
NMRI mice after olfactory bulbectomy- Comparator
- Saline-treated bulbectomized mice
- Outcome group
- Cognition and memory · Nervous system and cognition
- Studied dose
- 0.01 mg/kg · 21 daysAs given in this study (mouse).
Source sentences
Bulbectomized animals treated with saline failed to recognize this sector, while bulbectomized animals treated with noopept (0.01 mg/kg for 21 days) restored this predominance, thus demonstrating the improvement of the spatial memory.
2 context sentences(design, population, supporting numbers)
The effects of the novel proline-containing nootropic and neuroprotective dipeptide noopept (GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester) were studied on NMRI mice upon olfactory bulbectomy, which had been previously shown to imitate the main morphological and biochemical signs of Alzheimer's disease (AD).
The spatial memory was assessed using the Morris (water maze) test; the immunological status was characterized by ELISA with antibodies to prefibrillar beta-amyloid(25-35), S100b protein, and protofilaments of equine lysozyme, which are the molecular factors involved in the pathogenesis of AD.