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Study · Not a test of the peptide alone · 2005

4 results

Use of compounded adrenocorticotropic hormone (ACTH) for adrenal function testing in dogs.

Kemppainen RJ, Behrend EN, Busch KA

Journal of the American Animal Hospital Association1 Nov 2005Cited by 17 (Europe PMC)

PMID16267060 (opens in a new tab)DOI10.5326/0410368 (opens in a new tab)PepBankPUB-16267060
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cosyntropin.

  1. 01AnimalNot a test of Cosyntropin aloneAnimal study (in vivo)Activity measurement

    In healthy dogs, cortisol 30 minutes after cosyntropin was similar to that after compounded ACTH preparations.

    In plain wordsIn dogs, cortisol at 30 minutes was similar after cosyntropin and compounded ACTH.

    Peptide
    Cosyntropin
    Outcome
    No significant changeCortisol at 30 minutes
    Study

    dogn = 5

    Healthy dogs
    Comparator
    Compounded ACTH preparations
    Outcome group
    Adrenal Function · Endocrine and hormones

    Source sentences

    Summary
    Cortisol concentrations were similar at time 0 (pre-ACTH) and at 30 and 60 minutes after injection of all forms of ACTH.
    2 context sentences
    Summary · context
    The data showed that injection of four compounded forms of ACTH caused elevations in serum cortisol concentrations of a similar magnitude as cosyntropin in samples collected 60 minutes after administration; but concentrations at later times varied, depending on the type of ACTH used.
    Summary · context
    Serum cortisol concentrations were measured in five healthy dogs in response to five adrenocorticotropic hormone (ACTH) preparations.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  2. 02AnimalNot a test of Cosyntropin aloneAnimal study (in vivo)Activity measurement

    In healthy dogs, four compounded ACTH preparations caused cortisol elevations similar in magnitude to cosyntropin at 60 minutes.

    In plain wordsIn dogs, cortisol increases at 60 minutes were similar after cosyntropin and four compounded ACTH preparations.

    Peptide
    Cosyntropin
    Outcome
    No significant changeCortisol at 60 minutes
    Study

    dogn = 5

    Healthy dogs
    Comparator
    Four compounded ACTH preparations
    Outcome group
    Adrenal Function · Endocrine and hormones

    Source sentences

    Summary
    The data showed that injection of four compounded forms of ACTH caused elevations in serum cortisol concentrations of a similar magnitude as cosyntropin in samples collected 60 minutes after administration;
    1 context sentence
    Summary · context
    Serum cortisol concentrations were measured in five healthy dogs in response to five adrenocorticotropic hormone (ACTH) preparations.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  3. 03AnimalNot a test of Cosyntropin aloneAnimal study (in vivo)Activity measurement

    In healthy dogs, cortisol at 90 minutes was significantly lower after two compounded ACTH forms than after cosyntropin.

    In plain wordsIn dogs, cortisol at 90 minutes was lower after two compounded ACTH forms than after cosyntropin.

    Peptide
    Cosyntropin
    Outcome
    IncreaseCortisol at 90 minutes
    Study

    dogn = 5

    Healthy dogs
    Comparator
    Two compounded ACTH preparations
    Outcome group
    Adrenal Function · Endocrine and hormones

    Source sentences

    Summary
    However, at 90 and 120 minutes post-ACTH, serum cortisol concentrations were significantly lower following injection of two compounded forms of ACTH.
    2 context sentences
    Summary · context
    The data showed that injection of four compounded forms of ACTH caused elevations in serum cortisol concentrations of a similar magnitude as cosyntropin in samples collected 60 minutes after administration; but concentrations at later times varied, depending on the type of ACTH used.
    Summary · context
    Serum cortisol concentrations were measured in five healthy dogs in response to five adrenocorticotropic hormone (ACTH) preparations.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  4. 04AnimalNot a test of Cosyntropin aloneAnimal study (in vivo)Activity measurement

    In healthy dogs, cortisol at 120 minutes was significantly lower after two compounded ACTH forms than after cosyntropin.

    In plain wordsIn dogs, cortisol at 120 minutes was lower after two compounded ACTH forms than after cosyntropin.

    Peptide
    Cosyntropin
    Outcome
    IncreaseCortisol at 120 minutes
    Study

    dogn = 5

    Healthy dogs
    Comparator
    Two compounded ACTH preparations
    Outcome group
    Adrenal Function · Endocrine and hormones

    Source sentences

    Summary
    However, at 90 and 120 minutes post-ACTH, serum cortisol concentrations were significantly lower following injection of two compounded forms of ACTH.
    2 context sentences
    Summary · context
    The data showed that injection of four compounded forms of ACTH caused elevations in serum cortisol concentrations of a similar magnitude as cosyntropin in samples collected 60 minutes after administration; but concentrations at later times varied, depending on the type of ACTH used.
    Summary · context
    Serum cortisol concentrations were measured in five healthy dogs in response to five adrenocorticotropic hormone (ACTH) preparations.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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