Neonatal manipulation of oxytocin affects expression of estrogen receptor alpha.

Yamamoto Y, Carter CS, Cushing BS

Neuroscience28 Oct 2005Cited by 50 (Europe PMC)

PMID16257490DOI10.1016/j.neuroscience.2005.08.065PepBankPUB-16257490

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In female prairie voles given oxytocin on the first day of life, estrogen receptor alpha-immunoreactive cells in the ventromedial hypothalamus were more numerous on postnatal day 21.
In plain wordsIn female prairie voles, oxytocin given on day one of life raised the number of estrogen receptor cells in a brain area three weeks later.
Peptide
Oxytocin
Outcome
IncreaseEstrogen receptor alpha cells in VMH, females, postnatal day 21
Study
prairie volen: not reported in source
Comparator
Isotonic saline and handled, uninjected controls
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
3 µg (approximately 1 µg/g) · intraperitonealAs given in this study (prairie vole).
Source sentences
Summary
by postnatal day 21 females that received oxytocin showed a significant increase in the number of cells expressing estrogen receptor alpha-immunoreactivity in the ventromedial nucleus of the hypothalamus.
1 context sentence(design, population, supporting numbers)
Summary · context
On the first day of postnatal life male and female prairie voles (Microtus ochrogaster) were randomly assigned to receive one of four treatments; (a) 50 microl i.p. injection of 3 microg oxytocin (approximately 1 microg/g), (b) 0.3 microg of an oxytocin antagonist (approximately 0.1 microg/g), or (c) isotonic saline.
Report a problemFND-1625749001
02AnimalAnimal study (in vivo)Mechanism
In prairie voles given oxytocin on the first day of life, there were no significant treatment effects on estrogen receptor alpha on postnatal day 8.
In plain wordsIn prairie voles, oxytocin given on day one of life did not change estrogen receptor cells in the brain at one week.
Peptide
Oxytocin
Outcome
No significant changeEstrogen receptor alpha expression, postnatal day 8
Study
prairie volen: not reported in source
Comparator
Isotonic saline and handled, uninjected controls
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
3 µg (approximately 1 µg/g) · intraperitonealAs given in this study (prairie vole).
Source sentences
Summary
While there were no significant treatment effects on postnatal day 8
1 context sentence(design, population, supporting numbers)
Summary · context
On the first day of postnatal life male and female prairie voles (Microtus ochrogaster) were randomly assigned to receive one of four treatments; (a) 50 microl i.p. injection of 3 microg oxytocin (approximately 1 microg/g), (b) 0.3 microg of an oxytocin antagonist (approximately 0.1 microg/g), or (c) isotonic saline.
Report a problemFND-1625749002
03AnimalAnimal study (in vivo)Mechanism
In male prairie voles, there were no significant effects of the neonatal oxytocin manipulation on estrogen receptor alpha.
In plain wordsIn male prairie voles, oxytocin given on day one of life had no significant effect on estrogen receptor cells.
Peptide
Oxytocin
Outcome
No significant changeEstrogen receptor alpha expression in males
Study
prairie volen: not reported in source
Comparator
Isotonic saline and handled, uninjected controls
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
3 µg (approximately 1 µg/g) · intraperitonealAs given in this study (prairie vole).
Source sentences
Summary
While there were no significant effects in males, males treated with oxytocin antagonist trended toward a reduction in estrogen receptor alpha-immunoreactivity in the medial amygdala.
1 context sentence(design, population, supporting numbers)
Summary · context
On the first day of postnatal life male and female prairie voles (Microtus ochrogaster) were randomly assigned to receive one of four treatments; (a) 50 microl i.p. injection of 3 microg oxytocin (approximately 1 microg/g), (b) 0.3 microg of an oxytocin antagonist (approximately 0.1 microg/g), or (c) isotonic saline.
Report a problemFND-1625749003

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

04AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In female prairie voles, an oxytocin antagonist given on the first day of life significantly decreased estrogen receptor alpha immunoreactivity in the medial preoptic area on postnatal day 21.
In plain wordsIn female prairie voles, an oxytocin blocker given on day one of life lowered estrogen receptor cells in a brain area three weeks later.
Peptide
Oxytocin
Outcome
DecreaseEstrogen receptor alpha in MPOA, females, oxytocin antagonist
Study
prairie volen: not reported in source
Comparator
Isotonic saline and handled, uninjected controls
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Treatment with oxytocin antagonist resulted in a significant decrease in estrogen receptor alpha-immunoreactivity in the medial preoptic area in postnatal day 21 females.
1 context sentence(design, population, supporting numbers)
Summary · context
On the first day of postnatal life male and female prairie voles (Microtus ochrogaster) were randomly assigned to receive one of four treatments; (a) 50 microl i.p. injection of 3 microg oxytocin (approximately 1 microg/g), (b) 0.3 microg of an oxytocin antagonist (approximately 0.1 microg/g), or (c) isotonic saline.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1625749004
05AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In male prairie voles, an oxytocin antagonist only trended toward reducing estrogen receptor alpha immunoreactivity in the medial amygdala.
In plain wordsIn male prairie voles, an oxytocin blocker showed only a trend toward fewer estrogen receptor cells in one brain area.
Peptide
Oxytocin
Outcome
No significant changeEstrogen receptor alpha in medial amygdala, males, oxytocin antagonist
Study
prairie volen: not reported in source
Comparator
Isotonic saline and handled, uninjected controls
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
While there were no significant effects in males, males treated with oxytocin antagonist trended toward a reduction in estrogen receptor alpha-immunoreactivity in the medial amygdala.
1 context sentence(design, population, supporting numbers)
Summary · context
On the first day of postnatal life male and female prairie voles (Microtus ochrogaster) were randomly assigned to receive one of four treatments; (a) 50 microl i.p. injection of 3 microg oxytocin (approximately 1 microg/g), (b) 0.3 microg of an oxytocin antagonist (approximately 0.1 microg/g), or (c) isotonic saline.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1625749005

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:50 UTC
First added · source update from Europe PMC

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