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Study · Ex vivo tissue · sheep · 2006

4 results

Nongenomic action of progesterone inhibits oxytocin-induced phosphoinositide hydrolysis and prostaglandin F2alpha secretion in the ovine endometrium.

Bishop CV, Stormshak F

Endocrinology27 Oct 2005Cited by 19 (Europe PMC)

PMID16254031 (opens in a new tab)DOI10.1210/en.2005-0869 (opens in a new tab)PepBankPUB-16254031
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In ovine endometrial explants, oxytocin increased inositol monophosphate production, and progesterone had no detectable effect on it.

    In plain wordsIn sheep uterine lining tissue in the lab, oxytocin raised inositol monophosphate production.

    Peptide
    Oxytocin
    Outcome
    IncreaseInositol monophosphate production
    Study

    sheepn: not reported in source

    Ovine endometrial membranes and explants
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Oxytocin increased monophosphate production, but there was no detectable effect of P4.
    1 context sentence
    Summary · context
    Experiments were conducted to characterize the nongenomic effects of progesterone (P4) on binding of oxytocin (OT) to its receptor and signal transduction in the ovine endometrium.

Studies that did not test the peptide alone3

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 02LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In ovine endometrial membranes, progesterone interfered with oxytocin binding to its receptor in a dose-dependent manner.

    In plain wordsIn sheep uterine lining tissue in the lab, progesterone reduced oxytocin binding to its receptor, more at higher doses.

    Peptide
    Oxytocin
    Outcome
    DecreaseProgesterone effect on oxytocin receptor binding
    Study

    sheepn: not reported in source

    Ovine endometrial membranes and explants
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Source sentences

    Summary
    P4 interfered with the binding of OT in a dose-dependent manner.
    1 context sentence
    Summary · context
    Experiments were conducted to characterize the nongenomic effects of progesterone (P4) on binding of oxytocin (OT) to its receptor and signal transduction in the ovine endometrium.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 03LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In ovine endometrial explants, preincubation with progesterone significantly interfered with oxytocin stimulation of IP2 and IP3 synthesis.

    In plain wordsIn sheep uterine lining tissue in the lab, progesterone blocked part of the oxytocin signal.

    Peptide
    Oxytocin
    Outcome
    DecreaseProgesterone effect on oxytocin-stimulated IP2 and IP3 synthesis
    Study

    sheepn: not reported in source

    Ovine endometrial membranes and explants
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Source sentences

    Summary
    Preincubation with P4 for 10 min significantly interfered with OT stimulation of IP(2) and IP(3) synthesis.
    1 context sentence
    Summary · context
    Experiments were conducted to characterize the nongenomic effects of progesterone (P4) on binding of oxytocin (OT) to its receptor and signal transduction in the ovine endometrium.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 04LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In ovine endometrial explants, brief exposure to progesterone significantly decreased oxytocin-induced PGF2alpha secretion.

    In plain wordsIn sheep uterine lining tissue in the lab, progesterone reduced the prostaglandin release that oxytocin causes.

    Peptide
    Oxytocin
    Outcome
    DecreaseProgesterone effect on oxytocin-induced PGF2alpha secretion
    Study

    sheepn: not reported in source

    Ovine endometrial membranes and explants
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Source sentences

    Summary
    Brief exposure to P4 significantly decreased OT-induced PGF(2alpha) secretion from explants previously exposed to medium or AA.
    1 context sentence
    Summary · context
    Experiments were conducted to characterize the nongenomic effects of progesterone (P4) on binding of oxytocin (OT) to its receptor and signal transduction in the ovine endometrium.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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