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Study · Not a test of the peptide alone · 2006

2 results

Effect of constitutive expression of porcine IGFBP-3 on proliferation and differentiation of L6 myogenic cells.

Xi G, Kamanga-Sollo E, Hathaway MR, Dayton WR, White ME

Domestic animal endocrinology3 Oct 2005Cited by 9 (Europe PMC)

PMID16233971 (opens in a new tab)DOI10.1016/j.domaniend.2005.09.008 (opens in a new tab)PepBankPUB-16233971
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 LR3.

  1. 01LabNot a test of IGF-1 LR3 aloneIn vitro (cells)Mechanism

    In L6 myogenic cells that produce porcine IGFBP-3, immunoneutralization of IGFBP-3 increased Long-R3-IGF-I-stimulated proliferation by 33%.

    In plain wordsIn cells, blocking IGFBP-3 raised the growth of muscle cells that Long-R3-IGF-I had stimulated. The agent tested was the IGFBP-3 block.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseLong-R3-IGF-I-stimulated proliferation after IGFBP-3 immunoneutralization
    Study

    ratn: not reported in source

    L6 myogenic cells constitutively expressing porcine IGFBP-3 (tL6)
    Outcome group
    Cell proliferation and differentiation · Musculoskeletal

    Measurements

    Proliferation increase
    33%
    Long-R3-IGF-I-stimulated tL6 cells

    Source sentences

    Summary
    Immunoneutralization of IGFBP-3 increased both IGF-I- and Long-R3-IGF-I-stimulated proliferation of tL6 cells (58 and 33%, respectively) (P<0.01).
    1 context sentence
    Summary · context
    In order to assess the effects of endogenously produced IGFBP-3, we have transfected L6 myogenic cells with a pEF6/V5 vector containing pIGFBP-3 cDNA under the control of the human elongation factor 1alpha (hEF-1alpha) promoter and with the empty vector.

    In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.

  2. 02LabNot a test of IGF-1 LR3 aloneIn vitro (cells)Mechanism

    In L6 myogenic cells that produce porcine IGFBP-3, immunoneutralization of IGFBP-3 had no effect on Long-R3-IGF-I-stimulated differentiation.

    In plain wordsIn cells, blocking IGFBP-3 did not change how far muscle cells matured when Long-R3-IGF-I stimulated them. The agent tested was the IGFBP-3 block.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeLong-R3-IGF-I-stimulated differentiation after IGFBP-3 immunoneutralization
    Study

    ratn: not reported in source

    L6 myogenic cells constitutively expressing porcine IGFBP-3 (tL6)
    Outcome group
    Cell proliferation and differentiation · Musculoskeletal

    Source sentences

    Summary
    Immunoneutralization of IGFBP-3 also increased IGF-I-stimulated differentiation (21%, P<0.05) but had no effect on Long-R3-IGF-I stimulated differentiation of tL6 myogenic cells.
    1 context sentence
    Summary · context
    In order to assess the effects of endogenously produced IGFBP-3, we have transfected L6 myogenic cells with a pEF6/V5 vector containing pIGFBP-3 cDNA under the control of the human elongation factor 1alpha (hEF-1alpha) promoter and with the empty vector.

    In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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