Skip to content

Study · Not a test of the peptide alone · 1999

3 results

Effectiveness of polyamidoamine dendrimers modified with tripeptide growth factor, glycyl-L-histidyl-L-lysine, for enhancement of function of hepatoma cells.

Kawase M, Kurikawa N, Higashiyama S, Miura N, Shiomi T, Ozawa C, Mizoguchi T, Yagi K

Journal of bioscience and bioengineering1 Jan 1999Cited by 10 (Europe PMC)

PMID16232640 (opens in a new tab)DOI10.1016/s1389-1723(99)80222-9 (opens in a new tab)PepBankPUB-16232640
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHK (glycyl-L-histidyl-L-lysine).

  1. 01LabNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneIn vitro (cells)Efficacy outcome

    In rat hepatoma cells, increasing GHK-dendrimer generations inhibited cell growth.

    In plain wordsIn cells from rat hepatoma, higher-generation GHK-dendrimers inhibited growth compared with lower-generation dendrimers.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    DecreaseCell growth
    Study

    ratn: not reported in source

    H4-H-E-C3 hepatoma cells
    Comparator
    Lower-generation GHK-dendrimers
    Outcome group
    Tumor growth · Liver

    Source sentences

    Summary
    The growth of cells was inhibited by increasing the number of generations of GHK-dendrimers.
    1 context sentence
    Summary · context
    Tripeptide growth factor, glycyl-L-histidyl-L-lysine (GHK), was employed as a ligand for activation or attachment of cells from a rat hepatoma cell line, H4-H-E-C3, and immobilized at the terminus of the dendrimer (GHK-dendrimer)

    In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).

  2. 02LabNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneIn vitro (cells)Efficacy outcome

    In rat hepatoma cells, fifth generation GHK-dendrimers enhanced urea synthesis more than first generation GHK-dendrimers.

    In plain wordsIn cells from rat hepatoma, fifth generation GHK-dendrimers increased urea synthesis more than first generation dendrimers.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    IncreaseUrea synthesis
    Study

    ratn: not reported in source

    H4-H-E-C3 hepatoma cells
    Comparator
    First generation GHK-dendrimers
    Outcome group
    Liver fat and liver function · Liver

    Source sentences

    Summary
    On the other hand, urea synthesis and lidocaine clearance of the cells adhered on fifth generation GHK-dendrimers were enhanced much more than on first generation GHK-dendrimers.
    1 context sentence
    Summary · context
    Tripeptide growth factor, glycyl-L-histidyl-L-lysine (GHK), was employed as a ligand for activation or attachment of cells from a rat hepatoma cell line, H4-H-E-C3, and immobilized at the terminus of the dendrimer (GHK-dendrimer)

    In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).

  3. 03LabNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneIn vitro (cells)Efficacy outcome

    In rat hepatoma cells, fifth generation GHK-dendrimers enhanced lidocaine clearance more than first generation GHK-dendrimers.

    In plain wordsIn cells from rat hepatoma, fifth generation GHK-dendrimers increased lidocaine clearance more than first generation dendrimers.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    IncreaseLidocaine clearance
    Study

    ratn: not reported in source

    H4-H-E-C3 hepatoma cells
    Comparator
    First generation GHK-dendrimers
    Outcome group
    Liver fat and liver function · Liver

    Source sentences

    Summary
    On the other hand, urea synthesis and lidocaine clearance of the cells adhered on fifth generation GHK-dendrimers were enhanced much more than on first generation GHK-dendrimers.
    1 context sentence
    Summary · context
    Tripeptide growth factor, glycyl-L-histidyl-L-lysine (GHK), was employed as a ligand for activation or attachment of cells from a rat hepatoma cell line, H4-H-E-C3, and immobilized at the terminus of the dendrimer (GHK-dendrimer)

    In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.