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Study · Ex vivo tissue · pig · 2005

2 results

Porcine vaginal mucosa as an in vitro permeability model for human vaginal mucosa.

van Eyk AD, van der Bijl P

International journal of pharmaceutics13 Oct 2005Cited by 40 (Europe PMC)

PMID16226413 (opens in a new tab)DOI10.1016/j.ijpharm.2005.09.002 (opens in a new tab)PepBankPUB-16226413
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissuePharmacokinetics

    In vitro, the mean steady state flux of oxytocin was about 53% higher through porcine vaginal mucosa than through human vaginal mucosa.

    In plain wordsIn lab tests, oxytocin passed through pig vaginal tissue faster than through human vaginal tissue.

    Peptide
    Oxytocin
    Outcome
    IncreaseMean steady state flux of oxytocin
    Study

    pig, humann: not reported in source

    vaginal mucosa, flow-through diffusion apparatus
    Comparator
    Human vaginal mucosa
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · 24 hAs given in this study (pig, human).

    Measurements

    Flux difference, porcine versus human
    ≈ 53%
    oxytocin

    Source sentences

    Summary
    those for 17beta-estradiol and oxytocin were approximately 17 and 53% higher, through porcine vaginal mucosa as compared to human vaginal mucosa, respectively.
    2 context sentences
    Summary · context
    In this study, porcine vaginal mucosa was used as an in vitro permeability model for human vaginal mucosa using tritium-labelled permeants (17beta-estradiol, r-arecoline, vasopressin, oxytocin and water).
    Summary · context
    In vitro permeability studies were performed using a flow-through diffusion apparatus (24 h, 20 degrees C, 1.5 ml/h).
  2. 02LabEx vivo tissuePharmacokinetics

    In vitro, the F-test showed a statistically significant difference in the diffusion of oxytocin between human and porcine vaginal mucosa.

    In plain wordsIn lab tests, oxytocin diffused differently through pig and human vaginal tissue.

    Peptide
    Oxytocin
    Outcome
    MixedDiffusion curve of oxytocin, porcine versus human mucosa
    Study

    pig, humann: not reported in source

    vaginal mucosa, flow-through diffusion apparatus
    Comparator
    Human vaginal mucosa
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · 24 hAs given in this study (pig, human).

    Source sentences

    Summary
    Using a F-test (comparing whole curves), statistically significant differences in the diffusion of 17beta-estradiol, r-arecoline and oxytocin were indicated when comparing human and porcine vaginal mucosa.
    2 context sentences
    Summary · context
    In this study, porcine vaginal mucosa was used as an in vitro permeability model for human vaginal mucosa using tritium-labelled permeants (17beta-estradiol, r-arecoline, vasopressin, oxytocin and water).
    Summary · context
    In vitro permeability studies were performed using a flow-through diffusion apparatus (24 h, 20 degrees C, 1.5 ml/h).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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