Early postnatal effects of noopept and piracetam on declarative and procedural memory of adult male and female rats.

Trofimov SS, Voronina TA, Guzevatykh LS

Bulletin of experimental biology and medicine1 Jun 2005Cited by 1 (Europe PMC)

PMID16224581DOI10.1007/s10517-005-0378-zPepBankPUB-16224581

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, early postnatal noopept disturbed learning dynamics measured through declarative memory parameters.
In plain wordsIn rats, early noopept treatment impaired learning measured through declarative memory.
Peptide
Noopept (omberacetam)
Outcome
DecreaseDeclarative memory learning dynamics
Study
ratn: not reported in source
Adult rats after early postnatal treatment
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · subcutaneous · days 8-20 of lifeAs given in this study (rat).
Source sentences
Summary
Early postnatal administration of Noopept disturbed the dynamics of learning by parameters of declarative and procedural memory.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the effect of a new nootropic dipeptide Noopept and reference nootropic preparation piracetam injected subcutaneously on days 8-20 of life on learning of alternative feeding response in a 6-arm-maze in male and female rats.
Report a problemFND-1622458101
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, early postnatal noopept disturbed learning dynamics measured through procedural memory parameters.
In plain wordsIn rats, early noopept treatment impaired learning measured through procedural memory.
Peptide
Noopept (omberacetam)
Outcome
DecreaseProcedural memory learning dynamics
Study
ratn: not reported in source
Adult rats after early postnatal treatment
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · subcutaneous · days 8-20 of lifeAs given in this study (rat).
Source sentences
Summary
Early postnatal administration of Noopept disturbed the dynamics of learning by parameters of declarative and procedural memory.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the effect of a new nootropic dipeptide Noopept and reference nootropic preparation piracetam injected subcutaneously on days 8-20 of life on learning of alternative feeding response in a 6-arm-maze in male and female rats.
Report a problemFND-1622458102
03AnimalAnimal study (in vivo)Efficacy outcome
In male rats, early postnatal noopept decreased the proportion that successfully learned the task.
In plain wordsIn male rats, early noopept treatment reduced the proportion that learned the task successfully.
Peptide
Noopept (omberacetam)
Outcome
DecreaseSuccessful learning proportion
Study
ratn: not reported in source
Adult male rats after early postnatal treatment
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · subcutaneous · days 8-20 of lifeAs given in this study (rat).
Source sentences
Summary
Both preparations decreased the ratio of successfully learned males (but not females).
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the effect of a new nootropic dipeptide Noopept and reference nootropic preparation piracetam injected subcutaneously on days 8-20 of life on learning of alternative feeding response in a 6-arm-maze in male and female rats.
Report a problemFND-1622458103
04AnimalAnimal study (in vivo)Efficacy outcome
In female rats, early postnatal noopept did not decrease the proportion that successfully learned the task.
In plain wordsIn female rats, early noopept treatment did not reduce the proportion that learned successfully.
Peptide
Noopept (omberacetam)
Outcome
No significant changeSuccessful learning proportion
Study
ratn: not reported in source
Adult female rats after early postnatal treatment
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · subcutaneous · days 8-20 of lifeAs given in this study (rat).
Source sentences
Summary
Both preparations decreased the ratio of successfully learned males (but not females).
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the effect of a new nootropic dipeptide Noopept and reference nootropic preparation piracetam injected subcutaneously on days 8-20 of life on learning of alternative feeding response in a 6-arm-maze in male and female rats.
Report a problemFND-1622458104
05AnimalAnimal study (in vivo)Mechanism
In rats, the reported noopept effects were not associated with changes in locomotor activity.
In plain wordsIn rats, noopept's reported effects were not linked to changes in movement activity.
Peptide
Noopept (omberacetam)
Outcome
No significant changeAssociation with locomotor activity changes
Study
ratn: not reported in source
Adult rats after early postnatal treatment
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · subcutaneous · days 8-20 of lifeAs given in this study (rat).
Source sentences
Summary
The observed effects were not associated with changes in locomotor activity.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the effect of a new nootropic dipeptide Noopept and reference nootropic preparation piracetam injected subcutaneously on days 8-20 of life on learning of alternative feeding response in a 6-arm-maze in male and female rats.
Report a problemFND-1622458105

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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