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Study · Not a test of the peptide alone · 2005

1 result

Insulin-like growth factor binding protein (IGFBP)-3 and IGFBP-5 mediate TGF-beta- and myostatin-induced suppression of proliferation in porcine embryonic myogenic cell cultures.

Kamanga-Sollo E, Pampusch MS, White ME, Hathaway MR, Dayton WR

Experimental cell research6 Oct 2005Cited by 28 (Europe PMC)

PMID16214131 (opens in a new tab)DOI10.1016/j.yexcr.2005.09.003 (opens in a new tab)PepBankPUB-16214131
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 LR3.

  1. 01LabNot a test of IGF-1 LR3 aloneIn vitro (cells)Mechanism

    In porcine myogenic cells treated with TGF-beta1 or myostatin, simultaneous immunoneutralization of IGFBP-3 and IGFBP-5 restored Long-R3-IGF-I-stimulated DNA synthesis to 90% of control levels.

    In plain wordsIn cells, blocking IGFBP-3 and IGFBP-5 brought DNA synthesis back to 90% of control levels. The agent tested was the IGFBP block.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseLong-R3-IGF-I-stimulated DNA synthesis after IGFBP-3 and IGFBP-5 immunoneutralization
    Study

    pign: not reported in source

    Porcine embryonic myogenic cell (PEMC) cultures treated with TGF-beta1 or myostatin
    Comparator
    Control cultures without TGF-beta1 or myostatin
    Outcome group
    Cell proliferation and differentiation · Musculoskeletal

    Measurements

    DNA synthesis rate restored
    90%
    versus control cultures

    Source sentences

    Summary
    Simultaneous immunoneutralization of both IGFBP-3 and IGFBP-5 in TGF-beta1 or myostatin-treated PEMC cultures restores Long-R3-IGF-I-stimulated DNA synthesis rates to 90% of the levels observed in control cultures receiving no TGF-beta1 or myostatin treatment (P < 0.05).

    In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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