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Study · Animal study (in vivo) · rat · 2006

4 results

Effect of the melanocortin receptor stimulation or inhibition on ethanol intake in alcohol-preferring rats.

Polidori C, Geary N, Massi M

Peptides28 Sept 2005Cited by 19 (Europe PMC)

PMID16198024 (opens in a new tab)DOI10.1016/j.peptides.2005.07.008 (opens in a new tab)PepBankPUB-16198024
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In alcohol-preferring rats with 2 h/day ethanol access, lateral ventricular MTII injections reduced ethanol intake.

    In plain wordsIn rats that prefer alcohol, MTII injected into the brain ventricle reduced ethanol intake.

    Peptide
    Melanotan II
    Outcome
    DecreaseEthanol intake with 2 h/day access
    Study

    ratn: not reported in source

    Marchigian-Sardinian alcohol-preferring (msP) rats
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    0.01-1 nmol · lateral ventricular injection · acuteAs given in this study (rat).

    Source sentences

    Summary
    The data showed that with 2h/day ethanol access, LV MTII injections reduced intake of food and ethanol intakes.
    1 context sentence
    Summary · context
    in Marchigian-Sardinian alcohol-preferring (msP) rats, which spontaneously ingest pharmacologically relevant quantities of ethanol both under short and long term access conditions
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In alcohol-preferring rats with 2 h/day ethanol access, lateral ventricular MTII injections reduced food intake.

    In plain wordsIn rats that prefer alcohol, MTII injected into the brain ventricle reduced food intake.

    Peptide
    Melanotan II
    Outcome
    DecreaseFood intake with 2 h/day ethanol access
    Study

    ratn: not reported in source

    Marchigian-Sardinian alcohol-preferring (msP) rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.01-1 nmol · lateral ventricular injection · acuteAs given in this study (rat).

    Source sentences

    Summary
    The data showed that with 2h/day ethanol access, LV MTII injections reduced intake of food and ethanol intakes.
    1 context sentence
    Summary · context
    in Marchigian-Sardinian alcohol-preferring (msP) rats, which spontaneously ingest pharmacologically relevant quantities of ethanol both under short and long term access conditions
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In alcohol-preferring rats with ad libitum access, daily MTII reduced ethanol intake for only the first 2 days of 5 days of treatment.

    In plain wordsIn rats that prefer alcohol, daily MTII lowered ethanol intake only on the first 2 days of treatment.

    Peptide
    Melanotan II
    Outcome
    MixedEthanol intake during daily MTII with ad libitum access
    Study

    ratn: not reported in source

    Marchigian-Sardinian alcohol-preferring (msP) rats
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    0.01 nmol · lateral ventricular injection · 5 daysAs given in this study (rat).

    Source sentences

    Summary
    When food, water, and ethanol were available ad libitum and 0.01 nmol MTII was given by daily LV injection, however, ethanol intake was reduced for only the first 2 days, whereas food intake was reduced for all 5 days of treatment.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In alcohol-preferring rats with ad libitum access, daily MTII reduced food intake on all 5 days of treatment.

    In plain wordsIn rats that prefer alcohol, daily MTII lowered food intake on all 5 days of treatment.

    Peptide
    Melanotan II
    Outcome
    DecreaseFood intake during daily MTII with ad libitum access
    Study

    ratn: not reported in source

    Marchigian-Sardinian alcohol-preferring (msP) rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.01 nmol · lateral ventricular injection · 5 daysAs given in this study (rat).

    Source sentences

    Summary
    When food, water, and ethanol were available ad libitum and 0.01 nmol MTII was given by daily LV injection, however, ethanol intake was reduced for only the first 2 days, whereas food intake was reduced for all 5 days of treatment.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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