[Effects of the new peptide anxiolytic drug selank on the cardiovascular system functioning and respiration in cats].

Gan'shina TS, Kozlovskiĭ II

Eksperimental'naia i klinicheskaia farmakologiia1 Jul 2005

PMID16193654PepBankPUB-16193654

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In narcotized cats, intravenous Selank decreased arterial pressure for the first 1-3 minutes after injection.
In plain wordsIn cats under anaesthesia, Selank briefly lowered blood pressure after injection.
Peptide
Selank
Outcome
DecreaseArterial pressure
Study
catn: not reported in source
narcotized male cats
Outcome group
Blood pressure · Cardiovascular
Studied dose
300 mg/kg · intravenousAs given in this study (cat).
Measurements
Arterial pressure decrease
32%
first 1-3 min after injection
Source sentences
Summary
Selank produced a 32 +/- 4.3% decrease in the AP for the first 1-3 min after injection.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of the new heptapeptide anxiolytic drug selank (300 mg/kg, i.v.) on the arterial pressure (AP), cerebral blood flow, heart rhythm, respiration, and the AP depression induced by acetylcholine injections was recorded in narcotized male cats.
Report a problemFND-1619365401
02AnimalAnimal study (in vivo)Efficacy outcome
In narcotized cats, Selank increased cerebral blood flow for the first 5-10 minutes after injection, then flow returned to the initial level.
In plain wordsIn cats under anaesthesia, Selank briefly increased blood flow in the brain after injection.
Peptide
Selank
Outcome
IncreaseCerebral blood flow
Study
catn: not reported in source
narcotized male cats
Outcome group
Cerebral blood flow · Cardiovascular
Studied dose
300 mg/kg · intravenousAs given in this study (cat).
Measurements
Cerebral blood flow increase
24%
first 5-10 min after injection
Source sentences
Summary
The drug also induced a 24 +/- 2.8% increase in the cerebral blood flow for the first 5 - 10 min upon injection and then the blood flow was gradually restored on the initial level.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of the new heptapeptide anxiolytic drug selank (300 mg/kg, i.v.) on the arterial pressure (AP), cerebral blood flow, heart rhythm, respiration, and the AP depression induced by acetylcholine injections was recorded in narcotized male cats.
Report a problemFND-1619365402
03AnimalAnimal study (in vivo)Efficacy outcome
In narcotized cats, Selank did not affect the heart rate.
In plain wordsIn cats under anaesthesia, Selank did not change the heart rate.
Peptide
Selank
Outcome
No significant changeHeart rate
Study
catn: not reported in source
narcotized male cats
Outcome group
Heart function · Cardiovascular
Studied dose
300 mg/kg · intravenousAs given in this study (cat).
Source sentences
Summary
The heart rate and the respiratory rate were not affected by the drug injections.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of the new heptapeptide anxiolytic drug selank (300 mg/kg, i.v.) on the arterial pressure (AP), cerebral blood flow, heart rhythm, respiration, and the AP depression induced by acetylcholine injections was recorded in narcotized male cats.
Report a problemFND-1619365403
04AnimalAnimal study (in vivo)Efficacy outcome
In narcotized cats, Selank did not affect the respiratory rate.
In plain wordsIn cats under anaesthesia, Selank did not change the breathing rate.
Peptide
Selank
Outcome
No significant changeRespiratory rate
Study
catn: not reported in source
narcotized male cats
Outcome group
Respiratory function · Respiratory
Studied dose
300 mg/kg · intravenousAs given in this study (cat).
Source sentences
Summary
The heart rate and the respiratory rate were not affected by the drug injections.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of the new heptapeptide anxiolytic drug selank (300 mg/kg, i.v.) on the arterial pressure (AP), cerebral blood flow, heart rhythm, respiration, and the AP depression induced by acetylcholine injections was recorded in narcotized male cats.
Report a problemFND-1619365404
05AnimalAnimal study (in vivo)Efficacy outcome
In narcotized cats, Selank did not influence the arterial pressure depression caused by acetylcholine.
In plain wordsIn cats under anaesthesia, Selank did not change the drop in blood pressure caused by acetylcholine.
Peptide
Selank
Outcome
No significant changeAcetylcholine-induced arterial pressure depression
Study
catn: not reported in source
narcotized male cats
Outcome group
Blood pressure · Cardiovascular
Studied dose
300 mg/kg · intravenousAs given in this study (cat).
Source sentences
Summary
Nor did selank influence the AP depression in response to the acetylcholine introduction.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of the new heptapeptide anxiolytic drug selank (300 mg/kg, i.v.) on the arterial pressure (AP), cerebral blood flow, heart rhythm, respiration, and the AP depression induced by acetylcholine injections was recorded in narcotized male cats.
Report a problemFND-1619365405

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 17:28 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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