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Study · Animal study (in vivo) · mouse · 2005

7 results

Effects of injecting thymulin into the anterior or medial hypothalamus or the pituitary on induced ovulation in prepubertal mice.

García L, Hinojosa L, Domínguez R, Chavira R, Rosas P

Neuroimmunomodulation1 Jan 2005Cited by 11 (Europe PMC)

PMID16166812 (opens in a new tab)DOI10.1159/000087111 (opens in a new tab)PepBankPUB-16166812
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In prepubertal mice, anterior hypothalamic thymulin did not restore ovulation after ether anesthesia.

    In plain wordsIn mice, anterior hypothalamic thymulin did not restore ovulation after ether anesthesia compared with saline injection.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeOvulation after anterior hypothalamic injection
    Study

    mousen: not reported in source

    ether-anesthetized prepubertal female mice receiving eCG
    Comparator
    saline injection
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · anterior hypothalamic injectionAs given in this study (mouse).

    Source sentences

    Summary
    Injecting thymulin directly into the anterior hypothalamus did not restore ovulation, nor diminish the number of atretic follicles.
    1 context sentence
    Summary · context
    Female mice, 19 days old, were anesthetized with ether and injected with saline solution or thymulin into the anterior or medial hypothalamus or the pituitary and treated with eCG when 20 days old.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In prepubertal mice, anterior hypothalamic thymulin did not reduce atretic follicle numbers.

    In plain wordsIn mice, anterior hypothalamic thymulin did not reduce atretic follicle numbers compared with saline injection.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeFollicular atresia after anterior hypothalamic injection
    Study

    mousen: not reported in source

    ether-anesthetized prepubertal female mice receiving eCG
    Comparator
    saline injection
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · anterior hypothalamic injectionAs given in this study (mouse).

    Source sentences

    Summary
    Injecting thymulin directly into the anterior hypothalamus did not restore ovulation, nor diminish the number of atretic follicles.
    1 context sentence
    Summary · context
    Female mice, 19 days old, were anesthetized with ether and injected with saline solution or thymulin into the anterior or medial hypothalamus or the pituitary and treated with eCG when 20 days old.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In prepubertal mice, medial hypothalamic thymulin restored the ovulation ratio after ether anesthesia.

    In plain wordsIn mice, medial hypothalamic thymulin restored the ovulation ratio after ether anesthesia compared with saline injection.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseOvulation ratio after medial hypothalamic injection
    Study

    mousen: not reported in source

    ether-anesthetized prepubertal female mice receiving eCG
    Comparator
    saline injection
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · medial hypothalamic injectionAs given in this study (mouse).

    Source sentences

    Summary
    In contrast, injecting thymulin into the medial hypothalamus restored the ovulation ratio and decreased the percentage of atretic follicles.
    1 context sentence
    Summary · context
    Female mice, 19 days old, were anesthetized with ether and injected with saline solution or thymulin into the anterior or medial hypothalamus or the pituitary and treated with eCG when 20 days old.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In prepubertal mice, medial hypothalamic thymulin decreased the percentage of atretic follicles.

    In plain wordsIn mice, medial hypothalamic thymulin decreased the percentage of atretic follicles compared with saline injection.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseFollicular atresia after medial hypothalamic injection
    Study

    mousen: not reported in source

    ether-anesthetized prepubertal female mice receiving eCG
    Comparator
    saline injection
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · medial hypothalamic injectionAs given in this study (mouse).

    Source sentences

    Summary
    In contrast, injecting thymulin into the medial hypothalamus restored the ovulation ratio and decreased the percentage of atretic follicles.
    1 context sentence
    Summary · context
    Female mice, 19 days old, were anesthetized with ether and injected with saline solution or thymulin into the anterior or medial hypothalamus or the pituitary and treated with eCG when 20 days old.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In prepubertal mice, pituitary thymulin restored ovulation after ether anesthesia.

    In plain wordsIn mice, pituitary thymulin restored ovulation after ether anesthesia compared with saline injection.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseOvulation after pituitary injection
    Study

    mousen: not reported in source

    ether-anesthetized prepubertal female mice receiving eCG
    Comparator
    saline injection
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · pituitary injectionAs given in this study (mouse).

    Source sentences

    Summary
    Similar results were obtained by injecting thymulin into the pituitary, though thymulin treatment in the pituitary resulted in a higher number of ova shed and lower follicular atresia.
    2 context sentences
    Summary · context
    In contrast, injecting thymulin into the medial hypothalamus restored the ovulation ratio and decreased the percentage of atretic follicles.
    Summary · context
    Female mice, 19 days old, were anesthetized with ether and injected with saline solution or thymulin into the anterior or medial hypothalamus or the pituitary and treated with eCG when 20 days old.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In prepubertal mice, pituitary thymulin produced more ova shed than medial hypothalamic thymulin.

    In plain wordsIn mice, pituitary thymulin produced more ova shed than medial hypothalamic thymulin.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseOva shed after pituitary injection
    Study

    mousen: not reported in source

    ether-anesthetized prepubertal female mice receiving eCG
    Comparator
    medial hypothalamic thymulin injection
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · pituitary injectionAs given in this study (mouse).

    Source sentences

    Summary
    Similar results were obtained by injecting thymulin into the pituitary, though thymulin treatment in the pituitary resulted in a higher number of ova shed and lower follicular atresia.
    2 context sentences
    Summary · context
    In contrast, injecting thymulin into the medial hypothalamus restored the ovulation ratio and decreased the percentage of atretic follicles.
    Summary · context
    Female mice, 19 days old, were anesthetized with ether and injected with saline solution or thymulin into the anterior or medial hypothalamus or the pituitary and treated with eCG when 20 days old.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In prepubertal mice, pituitary thymulin produced lower follicular atresia than medial hypothalamic thymulin.

    In plain wordsIn mice, pituitary thymulin produced lower follicular atresia than medial hypothalamic thymulin.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseFollicular atresia after pituitary injection
    Study

    mousen: not reported in source

    ether-anesthetized prepubertal female mice receiving eCG
    Comparator
    medial hypothalamic thymulin injection
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · pituitary injectionAs given in this study (mouse).

    Source sentences

    Summary
    Similar results were obtained by injecting thymulin into the pituitary, though thymulin treatment in the pituitary resulted in a higher number of ova shed and lower follicular atresia.
    2 context sentences
    Summary · context
    In contrast, injecting thymulin into the medial hypothalamus restored the ovulation ratio and decreased the percentage of atretic follicles.
    Summary · context
    Female mice, 19 days old, were anesthetized with ether and injected with saline solution or thymulin into the anterior or medial hypothalamus or the pituitary and treated with eCG when 20 days old.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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