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Study · Measured the body's own peptide · 2006

1 result

In vivo inhibition of nitric oxide synthase impairs upregulation of contractile protein mRNA in overloaded plantaris muscle.

Sellman JE, DeRuisseau KC, Betters JL, Lira VA, Soltow QA, Selsby JT, Criswell DS

Journal of applied physiology (Bethesda, Md. : 1985)15 Sept 2005Cited by 41 (Europe PMC)

PMID16166235 (opens in a new tab)DOI10.1152/japplphysiol.00936.2005 (opens in a new tab)PepBankPUB-16166235
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rats with overloaded plantaris, the NOS inhibitor TRIM increased overload-induced mechanogrowth factor mRNA compared with controls.

    In plain wordsIn rats, a drug that blocks nitric oxide synthase raised the body's own mechanogrowth factor response to muscle overload compared with controls.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseOverload-induced mechanogrowth factor mRNA with TRIM
    Study

    ratn: not reported in source

    Male Sprague-Dawley rats, overloaded plantaris
    Comparator
    Control overloaded muscle
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    However, OL induction of IGF-I and mechanogrowth factor mRNA was greater (P < 0.05) in the TRIM group compared with the controls.
    2 context sentences
    Summary · context
    Male Sprague-Dawley rats (approximately 350 g) were randomly divided into three treatment groups: control, N(G)-nitro-L-arginine methyl ester (L-NAME; 90 mg.kg(-1).day(-1)), and 1-(2-trifluoromethyl-phenyl)-imidazole (TRIM; 10 mg.kg(-1).day(-1)).
    Summary · context
    Unilateral removal of synergists induced chronic overload (OL) of the right plantaris.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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