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Study · Animal study (in vivo) · mouse · 2005

2 results

The local expression and abundance of insulin-like growth factor (IGF) binding proteins in skeletal muscle are regulated by age and gender but not local IGF-I in vivo.

Oliver WT, Rosenberger J, Lopez R, Gomez A, Cummings KK, Fiorotto ML

Endocrinology15 Sept 2005Cited by 15 (Europe PMC)

PMID16166219 (opens in a new tab)DOI10.1210/en.2005-0714 (opens in a new tab)PepBankPUB-16166219
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice at 5 and 10 weeks of age, injected LR3-IGF-I stimulated IGF-1R phosphorylation to a greater extent than IGF-I.

    In plain wordsIn mice, LR3-IGF-I switched on the IGF-1 receptor more than IGF-I did at 5 and 10 weeks of age.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseType 1 IGF receptor phosphorylation
    Study

    mousen: not reported in source

    Wild-type and SIS2 IGF-I-transgenic mice
    Comparator
    IGF-I
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    LR3-IGF-I stimulated IGF-1R phosphorylation to a greater extent than IGF-I at both 5 and 10 wk of age (P < 0.01)
    1 context sentence
    Summary · context
    Additional mice were injected with IGF-I or LR3-IGF-I, and phosphorylation of the type 1 IGF receptor (IGF-1R) was compared.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice, the greater IGF-1R phosphorylation with LR3-IGF-I than with IGF-I did not differ by gender or genotype.

    In plain wordsIn mice, the stronger receptor response to LR3-IGF-I than to IGF-I was the same in males and females and in both genotypes.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeType 1 IGF receptor phosphorylation by gender and genotype
    Study

    mousen: not reported in source

    Wild-type and SIS2 IGF-I-transgenic mice
    Comparator
    IGF-I
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    regardless of gender or genotype (P > 0.21).
    1 context sentence
    Summary · context
    Additional mice were injected with IGF-I or LR3-IGF-I, and phosphorylation of the type 1 IGF receptor (IGF-1R) was compared.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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