Effect of dose on response to adrenocorticotropin in extremely low birth weight infants.

Watterberg KL, Shaffer ML, Garland JS, Thilo EH, Mammel MC, Couser RJ, Aucott SW, Leach CL, Cole CH, Gerdes JS, Rozycki HJ, Backstrom C

The Journal of clinical endocrinology and metabolism13 Sept 2005Cited by 25 (Europe PMC)

PMID16159938DOI10.1210/jc.2005-0734PepBankPUB-16159938

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone10

In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cosyntropin.

01HumanNot a test of Cosyntropin aloneNon-randomized trialActivity measurement
In extremely low birth weight infants, 1.0 microg/kg cosyntropin yielded higher cortisol than 0.1 microg/kg (P < 0.001).
In plain wordsIn extremely low birth weight infants, the higher cosyntropin dose produced more cortisol than the lower dose.
Peptide
Cosyntropin
Outcome
IncreaseCortisol response by dose
Study
n = 276
Comparator
0.1 microg/kg cosyntropin
Outcome group
Adrenal Function · Endocrine and hormones
Measurements
P
< 0.001
cortisol values, 1.0 versus 0.1 microg/kg cosyntropin
Source sentences
Summary
Cosyntropin, at 1.0 vs. 0.1 microg/kg, yielded higher cortisol values (P < 0.001) and fewer negative responses (2 vs. 21%).
3 context sentences(design, population, supporting numbers)
Summary · context
The design was a prospective, nested study conducted within a randomized clinical trial of low-dose hydrocortisone from November 1, 2001, to April 30, 2003.
Summary · context
The patients included infants with 500-999 g birth weight.
Summary · context
The drug used was cosyntropin, at 1.0 or 0.1 microg/kg, given between 18 and 28 d of birth.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-1615993801
02HumanNot a test of Cosyntropin aloneNon-randomized trialActivity measurement
In extremely low birth weight infants, negative responses occurred in 2% with 1.0 microg/kg versus 21% with 0.1 microg/kg cosyntropin.
In plain wordsIn extremely low birth weight infants, the higher cosyntropin dose produced fewer negative responses than the lower dose.
Peptide
Cosyntropin
Outcome
DecreaseNegative response frequency
Study
n = 276
Comparator
0.1 microg/kg cosyntropin
Outcome group
Adrenal Function · Endocrine and hormones
Measurements
Negative responses
2%
1.0 microg/kg cosyntropin
Negative responses
21%
0.1 microg/kg cosyntropin
Source sentences
Summary
Cosyntropin, at 1.0 vs. 0.1 microg/kg, yielded higher cortisol values (P < 0.001) and fewer negative responses (2 vs. 21%).
3 context sentences(design, population, supporting numbers)
Summary · context
The design was a prospective, nested study conducted within a randomized clinical trial of low-dose hydrocortisone from November 1, 2001, to April 30, 2003.
Summary · context
The patients included infants with 500-999 g birth weight.
Summary · context
The drug used was cosyntropin, at 1.0 or 0.1 microg/kg, given between 18 and 28 d of birth.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-1615993802
03HumanNot a test of Cosyntropin aloneNon-randomized trialActivity measurement
In extremely low birth weight infants, responses to higher-dose cosyntropin differed between girls and boys (P = 0.02), unlike lower-dose responses.
In plain wordsIn extremely low birth weight infants, higher-dose cosyntropin responses differed between girls and boys, unlike lower-dose responses.
Peptide
Cosyntropin
Outcome
MixedSex difference in stimulated cortisol
Study
n: not reported in source
Comparator
Boys
Outcome group
Adrenal Function · Endocrine and hormones
Measurements
P
0.02
girls versus boys, 1.0 microg/kg cosyntropin
Source sentences
Summary
The higher dose, but not the lower dose, showed different responses for girls vs. boys (P = 0.02),
3 context sentences(design, population, supporting numbers)
Summary · context
The design was a prospective, nested study conducted within a randomized clinical trial of low-dose hydrocortisone from November 1, 2001, to April 30, 2003.
Summary · context
The patients included infants with 500-999 g birth weight.
Summary · context
The drug used was cosyntropin, at 1.0 or 0.1 microg/kg, given between 18 and 28 d of birth.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-1615993803
04HumanNot a test of Cosyntropin aloneNon-randomized trialActivity measurement
In extremely low birth weight infants, higher-dose cosyntropin responses differed with enteral nutrition (P < 0.001), unlike lower-dose responses.
In plain wordsIn extremely low birth weight infants, higher-dose cosyntropin responses differed with versus without enteral nutrition, unlike lower-dose responses.
Peptide
Cosyntropin
Outcome
MixedEnteral nutrition difference in stimulated cortisol
Study
n: not reported in source
Comparator
Infants not receiving enteral nutrition
Outcome group
Adrenal Function · Endocrine and hormones
Measurements
P
< 0.001
enteral nutrition versus not, 1.0 microg/kg cosyntropin
Source sentences
Summary
The higher dose, but not the lower dose, showed different responses for girls vs. boys (P = 0.02), infants receiving enteral nutrition vs. not (P < 0.001),
3 context sentences(design, population, supporting numbers)
Summary · context
The design was a prospective, nested study conducted within a randomized clinical trial of low-dose hydrocortisone from November 1, 2001, to April 30, 2003.
Summary · context
The patients included infants with 500-999 g birth weight.
Summary · context
The drug used was cosyntropin, at 1.0 or 0.1 microg/kg, given between 18 and 28 d of birth.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-1615993804
05HumanNot a test of Cosyntropin aloneNon-randomized trialActivity measurement
In extremely low birth weight infants, higher-dose cosyntropin responses differed with chorioamnionitis exposure (P = 0.04), unlike lower-dose responses.
In plain wordsIn extremely low birth weight infants, higher-dose responses differed with versus without chorioamnionitis exposure, unlike lower-dose responses.
Peptide
Cosyntropin
Outcome
MixedChorioamnionitis difference in stimulated cortisol
Study
n: not reported in source
Comparator
Infants without chorioamnionitis exposure
Outcome group
Adrenal Function · Endocrine and hormones
Measurements
P
0.04
chorioamnionitis exposure versus not, 1.0 microg/kg cosyntropin
Source sentences
Summary
The higher dose, but not the lower dose, showed different responses for girls vs. boys (P = 0.02), infants receiving enteral nutrition vs. not (P < 0.001), infants exposed to chorioamnionitis vs. not (P = 0.04),
3 context sentences(design, population, supporting numbers)
Summary · context
The design was a prospective, nested study conducted within a randomized clinical trial of low-dose hydrocortisone from November 1, 2001, to April 30, 2003.
Summary · context
The patients included infants with 500-999 g birth weight.
Summary · context
The drug used was cosyntropin, at 1.0 or 0.1 microg/kg, given between 18 and 28 d of birth.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-1615993805
06HumanNot a test of Cosyntropin aloneNon-randomized trialActivity measurement
In extremely low birth weight infants, higher-dose cosyntropin responses differed with mechanical ventilation (P = 0.02), unlike lower-dose responses.
In plain wordsIn extremely low birth weight infants, higher-dose responses differed with versus without mechanical ventilation, unlike lower-dose responses.
Peptide
Cosyntropin
Outcome
MixedVentilation difference in stimulated cortisol
Study
n: not reported in source
Comparator
Infants not receiving mechanical ventilation
Outcome group
Adrenal Function · Endocrine and hormones
Measurements
P
0.02
mechanical ventilation versus not, 1.0 microg/kg cosyntropin
Source sentences
Summary
The higher dose, but not the lower dose, showed different responses for girls vs. boys (P = 0.02), infants receiving enteral nutrition vs. not (P < 0.001), infants exposed to chorioamnionitis vs. not (P = 0.04), and those receiving mechanical ventilation vs. not (P = 0.02), as well
3 context sentences(design, population, supporting numbers)
Summary · context
The design was a prospective, nested study conducted within a randomized clinical trial of low-dose hydrocortisone from November 1, 2001, to April 30, 2003.
Summary · context
The patients included infants with 500-999 g birth weight.
Summary · context
The drug used was cosyntropin, at 1.0 or 0.1 microg/kg, given between 18 and 28 d of birth.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-1615993806
07HumanNot a test of Cosyntropin aloneNon-randomized trialActivity measurement
In extremely low birth weight infants, higher-dose cosyntropin responses correlated positively with fetal growth (P = 0.03), unlike lower-dose responses.
In plain wordsIn extremely low birth weight infants, higher-dose cosyntropin responses correlated positively with fetal growth, unlike lower-dose responses.
Peptide
Cosyntropin
Outcome
IncreaseFetal growth correlation with stimulated cortisol
Study
n: not reported in source
Outcome group
Adrenal Function · Endocrine and hormones
Measurements
P
0.03
correlation with fetal growth, 1.0 microg/kg cosyntropin
Source sentences
Summary
as well as a positive correlation with fetal growth (P = 0.03).
4 context sentences(design, population, supporting numbers)
Summary · context
The higher dose, but not the lower dose, showed different responses
Summary · context
The design was a prospective, nested study conducted within a randomized clinical trial of low-dose hydrocortisone from November 1, 2001, to April 30, 2003.
Summary · context
The patients included infants with 500-999 g birth weight.
Summary · context
The drug used was cosyntropin, at 1.0 or 0.1 microg/kg, given between 18 and 28 d of birth.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-1615993807
08HumanNot a test of Cosyntropin aloneNon-randomized trialActivity measurement
In enterally fed extremely low birth weight infants, the tenth percentile cortisol response to 1.0-microg/kg cosyntropin was 16.96 microg/dl.
In plain wordsIn enterally fed extremely low birth weight infants, the tenth percentile cortisol response to higher-dose cosyntropin was 16.96 microg/dl.
Peptide
Cosyntropin
Outcome
Not applicableCortisol response tenth percentile
Study
n: not reported in source
Outcome group
Adrenal Function · Endocrine and hormones
Measurements
10th percentile cortisol response
16.96 microg/dl
1.0 microg/kg cosyntropin, infants on enteral nutrition
Source sentences
Summary
A response curve for the 1.0-microg/kg dose for infants receiving enteral nutrition (proxy for clinically well infants) showed a 10th percentile of 16.96 microg/dl.
3 context sentences(design, population, supporting numbers)
Summary · context
The design was a prospective, nested study conducted within a randomized clinical trial of low-dose hydrocortisone from November 1, 2001, to April 30, 2003.
Summary · context
The patients included infants with 500-999 g birth weight.
Summary · context
The drug used was cosyntropin, at 1.0 or 0.1 microg/kg, given between 18 and 28 d of birth.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-1615993808
09HumanNot a test of Cosyntropin aloneObservational studyOther
In extremely low birth weight infants, cosyntropin responses below the 10th percentile were linked to more bronchopulmonary dysplasia.
In plain wordsIn extremely low birth weight infants, cosyntropin responses below the 10th percentile were linked to more bronchopulmonary dysplasia than higher responses.
Peptide
Cosyntropin
Outcome
IncreaseBronchopulmonary dysplasia association
Study
n: not reported in source
Comparator
Responses at or above the 10th percentile
Outcome group
Respiratory outcomes · Respiratory
Source sentences
Summary
Infants with responses less than the 10th percentile had more bronchopulmonary dysplasia and longer length of stay.
3 context sentences(design, population, supporting numbers)
Summary · context
The design was a prospective, nested study conducted within a randomized clinical trial of low-dose hydrocortisone from November 1, 2001, to April 30, 2003.
Summary · context
The patients included infants with 500-999 g birth weight.
Summary · context
The drug used was cosyntropin, at 1.0 or 0.1 microg/kg, given between 18 and 28 d of birth.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-1615993809
10HumanNot a test of Cosyntropin aloneObservational studyOther
In extremely low birth weight infants, cosyntropin responses below the 10th percentile were linked to longer hospital stays.
In plain wordsIn extremely low birth weight infants, cosyntropin responses below the 10th percentile were linked to longer hospital stays than higher responses.
Peptide
Cosyntropin
Outcome
IncreaseHospital stay association
Study
n: not reported in source
Comparator
Responses at or above the 10th percentile
Outcome group
Intensive care and hospital outcomes · Whole body
Source sentences
Summary
Infants with responses less than the 10th percentile had more bronchopulmonary dysplasia and longer length of stay.
3 context sentences(design, population, supporting numbers)
Summary · context
The design was a prospective, nested study conducted within a randomized clinical trial of low-dose hydrocortisone from November 1, 2001, to April 30, 2003.
Summary · context
The patients included infants with 500-999 g birth weight.
Summary · context
The drug used was cosyntropin, at 1.0 or 0.1 microg/kg, given between 18 and 28 d of birth.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-1615993810

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:37 UTC
First added · source update from Europe PMC

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