Tissue deiodinase activity during prolonged critical illness: effects of exogenous thyrotropin-releasing hormone and its combination with growth hormone-releasing peptide-2.

Debaveye Y, Ellger B, Mebis L, Van Herck E, Coopmans W, Darras V, Van den Berghe G

Endocrinology8 Sept 2005Cited by 34 (Europe PMC)

PMID16150898DOI10.1210/en.2005-0963PepBankPUB-16150898

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

2 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In burn-injured rabbits, GHRP‑2 alone normalized D3 activity, as did the other two interventions.
In plain wordsIn ill rabbits, GHRP‑2 alone brought a thyroid-related enzyme (D3) back to normal, as did the other two treatments.
Peptide
GHRP-2
Outcome
DecreaseHepatic D3 activity with GHRP-2
Study
rabbitn = 8
Burn-injured, parenterally fed rabbits (prolonged critical illness)
Comparator
Saline
Outcome group
Thyroid function · Endocrine and hormones
Studied dose
60 microg/kg.h · 4 daysAs given in this study (rabbit).
Source sentences
Summary
D3 activity was normalized by all three interventions
1 context sentence(design, population, supporting numbers)
Summary · context
Burn-injured, parenterally fed rabbits were randomized to receive 4-d treatment with saline, 60 microg/kg.h GHRP-2, 60 microg/kg.h TRH, or 60 microg/kg.h TRH plus 60 microg/kg.h GHRP-2 started on d 4 of the illness (n = 8/group).
Report a problemFND-1615089803
02AnimalAnimal study (in vivo)Efficacy outcome
In burn-injured rabbits, adding GHRP‑2 to TRH prevented the rise in rT3 seen with TRH alone.
In plain wordsIn ill rabbits, adding GHRP‑2 to TRH stopped the rise in rT3 that TRH alone caused.
Peptide
GHRP-2
Outcome
DecreaserT3 rise with TRH plus GHRP-2 versus TRH alone
Study
rabbitn = 8
Burn-injured, parenterally fed rabbits (prolonged critical illness)
Comparator
TRH alone
Outcome group
Thyroid function · Endocrine and hormones
Studied dose
60 microg/kg.h · 4 daysAs given in this study (rabbit).
Source sentences
Summary
only addition of GHRP-2 to TRH prevented the rise in rT(3) seen with TRH alone (P = 0.02).
1 context sentence(design, population, supporting numbers)
Summary · context
Burn-injured, parenterally fed rabbits were randomized to receive 4-d treatment with saline, 60 microg/kg.h GHRP-2, 60 microg/kg.h TRH, or 60 microg/kg.h TRH plus 60 microg/kg.h GHRP-2 started on d 4 of the illness (n = 8/group).
Report a problemFND-1615089804

Studies that did not test the peptide alone3

In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-2.

03AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Efficacy outcome
In burn-injured rabbits, infusion of TRH and of TRH plus GHRP‑2 restored hepatic type 1 deiodinase activity.
In plain wordsIn ill rabbits, TRH, and TRH plus GHRP‑2, restored a liver enzyme that makes active thyroid hormone.
Peptide
GHRP-2
Outcome
IncreaseHepatic D1 activity with TRH and TRH plus GHRP-2
Study
rabbitn = 8
Burn-injured, parenterally fed rabbits (prolonged critical illness)
Comparator
Saline
Outcome group
Thyroid function · Endocrine and hormones
Source sentences
Summary
Infusion of TRH and TRH plus GHRP-2 restored the catalytic activity of D1 (P = 0.02)
1 context sentence(design, population, supporting numbers)
Summary · context
Burn-injured, parenterally fed rabbits were randomized to receive 4-d treatment with saline, 60 microg/kg.h GHRP-2, 60 microg/kg.h TRH, or 60 microg/kg.h TRH plus 60 microg/kg.h GHRP-2 started on d 4 of the illness (n = 8/group).
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-1615089801
04AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Efficacy outcome
In burn-injured rabbits, TRH and TRH plus GHRP‑2 increased T3 levels back within the physiological range.
In plain wordsIn ill rabbits, TRH, and TRH plus GHRP‑2, brought T3 thyroid hormone back to a normal range.
Peptide
GHRP-2
Outcome
IncreaseCirculating T3 with TRH and TRH plus GHRP-2
Study
rabbitn = 8
Burn-injured, parenterally fed rabbits (prolonged critical illness)
Comparator
Saline
Outcome group
Thyroid function · Endocrine and hormones
Source sentences
Summary
Infusion of TRH and TRH plus GHRP-2 restored the catalytic activity of D1 (P = 0.02) and increased T(3) levels back within physiological range (P = 0.008).
1 context sentence(design, population, supporting numbers)
Summary · context
Burn-injured, parenterally fed rabbits were randomized to receive 4-d treatment with saline, 60 microg/kg.h GHRP-2, 60 microg/kg.h TRH, or 60 microg/kg.h TRH plus 60 microg/kg.h GHRP-2 started on d 4 of the illness (n = 8/group).
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-1615089802
05AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Mechanism
In burn-injured rabbits, liver D1 activity correlated positively and D3 activity negatively with T3 and the T3/rT3 ratio.
In plain wordsIn ill rabbits, liver D1 activity went up with T3 levels and D3 activity went down with them.
Peptide
GHRP-2
Outcome
MixedLiver D1 and D3 activity correlation with T3 and T3/rT3
Study
rabbitn = 8
Burn-injured, parenterally fed rabbits (prolonged critical illness)
Outcome group
Thyroid function · Endocrine and hormones
Source sentences
Summary
Liver D1 and D3 activity were correlated (respectively, positively and negatively) with the changes in circulating T(3) (r = 0.84 and r = -0.65) and the T(3)/rT(3) ratio (r = 0.71 and r = -0.60).
1 context sentence(design, population, supporting numbers)
Summary · context
Burn-injured, parenterally fed rabbits were randomized to receive 4-d treatment with saline, 60 microg/kg.h GHRP-2, 60 microg/kg.h TRH, or 60 microg/kg.h TRH plus 60 microg/kg.h GHRP-2 started on d 4 of the illness (n = 8/group).
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-1615089805

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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