Novel peptides prevent alcohol-induced spatial learning deficits and proinflammatory cytokine release in a mouse model of fetal alcohol syndrome.

Vink J, Auth J, Abebe DT, Brenneman DE, Spong CY

American journal of obstetrics and gynecology1 Sept 2005Cited by 43 (Europe PMC)

PMID16150281DOI10.1016/j.ajog.2005.02.101PepBankPUB-16150281

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone9

In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Davunetide.

01AnimalNot a test of Davunetide aloneAnimal study (in vivo)Efficacy outcome
In mouse embryos, NAPVSIPQ plus SALLRSIPA prevented the alcohol-induced increase in tumor necrosis factor-alpha.
In plain wordsIn mice, NAPVSIPQ plus SALLRSIPA prevented the tumor necrosis factor-alpha increase compared with alcohol alone.
Peptide
Davunetide
Outcome
DecreaseTumor necrosis factor-alpha
Study
mousen: not reported in source
Fetal alcohol syndrome
Comparator
Alcohol alone
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
NAPVSIPQ+SALLRSIPA pretreatment prevented this increase (39.9 9 +/- 2.8 pg/mL; P </= .01), with levels similar to control (P=.1).
3 context sentences(design, population, supporting numbers)
Summary · context
Alcohol treatment increased tumor necrosis factor-alpha levels versus control levels (50.0 +/- 3.5 pg/mL vs 32.7 +/- 2.4 pg/mL; P < .001).
Summary · context
We used a well-characterized mouse model of fetal alcohol syndrome.
Summary · context
Pretreatment with NAPVSIPQ+SALLRSIPA (20 mug) or placebo was given 30 minutes before alcohol.
In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.
Report a problemFND-1615028101
02AnimalNot a test of Davunetide aloneAnimal study (in vivo)Efficacy outcome
In mouse embryos, tumor necrosis factor-alpha after NAPVSIPQ plus SALLRSIPA pretreatment and alcohol was similar to control.
In plain wordsIn mice, tumor necrosis factor-alpha after the peptide combination and alcohol was similar to control.
Peptide
Davunetide
Outcome
No significant changeTumor necrosis factor-alpha versus control
Study
mousen: not reported in source
Fetal alcohol syndrome
Comparator
Control
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
NAPVSIPQ+SALLRSIPA pretreatment prevented this increase (39.9 9 +/- 2.8 pg/mL; P </= .01), with levels similar to control (P=.1).
2 context sentences(design, population, supporting numbers)
Summary · context
We used a well-characterized mouse model of fetal alcohol syndrome.
Summary · context
Pretreatment with NAPVSIPQ+SALLRSIPA (20 mug) or placebo was given 30 minutes before alcohol.
In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.
Report a problemFND-1615028102
03AnimalNot a test of Davunetide aloneAnimal study (in vivo)Efficacy outcome
In mouse embryos, NAPVSIPQ plus SALLRSIPA prevented the alcohol-induced increase in interleukin-6.
In plain wordsIn mice, NAPVSIPQ plus SALLRSIPA prevented the interleukin-6 increase compared with alcohol alone.
Peptide
Davunetide
Outcome
DecreaseInterleukin-6
Study
mousen: not reported in source
Fetal alcohol syndrome
Comparator
Alcohol alone
Outcome group
Inflammation markers · Immune and inflammation
Measurements
Interleukin-6
19.1 pg/mL
Peptide pretreatment and alcohol
Source sentences
Summary
Similarly, alcohol increased interleukin-6 levels versus control levels (22.6 +/- 1.4 pg/mL vs 17.3 +/- 0.6 pg/mL; P < .001), and NAPVSIPQ+SALLRSIPA prevented this increase (19.1 +/- 1.0 pg/mL; P </= .02), with levels similar to control levels (P=.2).
2 context sentences(design, population, supporting numbers)
Summary · context
We used a well-characterized mouse model of fetal alcohol syndrome.
Summary · context
Pretreatment with NAPVSIPQ+SALLRSIPA (20 mug) or placebo was given 30 minutes before alcohol.
In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.
Report a problemFND-1615028103
04AnimalNot a test of Davunetide aloneAnimal study (in vivo)Efficacy outcome
In mouse embryos, interleukin-6 after NAPVSIPQ plus SALLRSIPA pretreatment and alcohol was similar to control.
In plain wordsIn mice, interleukin-6 after the peptide combination and alcohol was similar to control.
Peptide
Davunetide
Outcome
No significant changeInterleukin-6 versus control
Study
mousen: not reported in source
Fetal alcohol syndrome
Comparator
Control
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
Similarly, alcohol increased interleukin-6 levels versus control levels (22.6 +/- 1.4 pg/mL vs 17.3 +/- 0.6 pg/mL; P < .001), and NAPVSIPQ+SALLRSIPA prevented this increase (19.1 +/- 1.0 pg/mL; P </= .02), with levels similar to control levels (P=.2).
2 context sentences(design, population, supporting numbers)
Summary · context
We used a well-characterized mouse model of fetal alcohol syndrome.
Summary · context
Pretreatment with NAPVSIPQ+SALLRSIPA (20 mug) or placebo was given 30 minutes before alcohol.
In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.
Report a problemFND-1615028104
05AnimalNot a test of Davunetide aloneAnimal study (in vivo)Efficacy outcome
In mouse embryos, interferon-gamma did not differ among alcohol, control, and alcohol plus NAPVSIPQ plus SALLRSIPA groups.
In plain wordsIn mice, interferon-gamma did not differ between the combination and alcohol group, alcohol alone, and control.
Peptide
Davunetide
Outcome
No significant changeInterferon-gamma
Study
mousen: not reported in source
Fetal alcohol syndrome
Comparator
Alcohol alone and control
Outcome group
Inflammation markers · Immune and inflammation
Measurements
Interferon-gamma
13.6 pg/mL
Alcohol plus NAPVSIPQ plus SALLRSIPA
Source sentences
Summary
Interferon-gamma levels were not different among the 3 groups (alcohol, 14.6 +/- 4.9 pg/mL; control, 17.9 +/- 6.6 pg/mL; alcohol+NAPVSIPQ+SALLRSIPA, 13.6 +/- 4.9 pg/mL; P=.2).
2 context sentences(design, population, supporting numbers)
Summary · context
We used a well-characterized mouse model of fetal alcohol syndrome.
Summary · context
Pretreatment with NAPVSIPQ+SALLRSIPA (20 mug) or placebo was given 30 minutes before alcohol.
In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.
Report a problemFND-1615028105
06AnimalNot a test of Davunetide aloneAnimal study (in vivo)Efficacy outcome
In adult mouse offspring, prenatal NAPVSIPQ plus SALLRSIPA pretreatment supported learning after alcohol exposure, whereas alcohol-only groups did not learn.
In plain wordsIn mice, prenatal peptide combination pretreatment supported learning after alcohol exposure compared with alcohol alone.
Peptide
Davunetide
Outcome
IncreaseSpatial learning after alcohol exposure
Study
mousen: not reported in source
Fetal alcohol syndrome
Comparator
Alcohol alone
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
Groups that were pretreated with NAPVSIPQ+SALLRSIPA then alcohol learned significantly, which was similar to the control group.
4 context sentences(design, population, supporting numbers)
Summary · context
In the Morris water maze, alcohol-treated groups did not learn over the 7-day trial compared with the control group (P=.001).
Summary · context
To test spatial learning, adult offspring from litters that were treated with alcohol, control, NAPVSIPQ+SALLRSIPA then alcohol, or NAPVSIPQ+SALLRSIPA alone were evaluated for latency to find a hidden platform in the Morris water maze.
Summary · context
We used a well-characterized mouse model of fetal alcohol syndrome.
Summary · context
Pretreatment with NAPVSIPQ+SALLRSIPA (20 mug) or placebo was given 30 minutes before alcohol.
In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.
Report a problemFND-1615028106
07AnimalNot a test of Davunetide aloneAnimal study (in vivo)Efficacy outcome
In adult mouse offspring, learning after prenatal NAPVSIPQ plus SALLRSIPA pretreatment and alcohol was similar to control.
In plain wordsIn mice, learning after prenatal peptide combination pretreatment and alcohol was similar to control.
Peptide
Davunetide
Outcome
No significant changeSpatial learning versus control
Study
mousen: not reported in source
Fetal alcohol syndrome
Comparator
Control
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
Groups that were pretreated with NAPVSIPQ+SALLRSIPA then alcohol learned significantly, which was similar to the control group.
3 context sentences(design, population, supporting numbers)
Summary · context
To test spatial learning, adult offspring from litters that were treated with alcohol, control, NAPVSIPQ+SALLRSIPA then alcohol, or NAPVSIPQ+SALLRSIPA alone were evaluated for latency to find a hidden platform in the Morris water maze.
Summary · context
We used a well-characterized mouse model of fetal alcohol syndrome.
Summary · context
Pretreatment with NAPVSIPQ+SALLRSIPA (20 mug) or placebo was given 30 minutes before alcohol.
In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.
Report a problemFND-1615028107
08AnimalNot a test of Davunetide aloneAnimal study (in vivo)Efficacy outcome
In adult mouse offspring, prenatal NAPVSIPQ plus SALLRSIPA alone produced significantly earlier learning.
In plain wordsIn mice, prenatal NAPVSIPQ plus SALLRSIPA alone produced earlier learning.
Peptide
Davunetide
Outcome
DecreaseLearning onset
Study
mousen: not reported in source
Fetal alcohol syndrome
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
Groups that were treated with only NAPVSIPQ+SALLRSIPA learned significantly earlier, with the shortest latency once learning commenced.
3 context sentences(design, population, supporting numbers)
Summary · context
To test spatial learning, adult offspring from litters that were treated with alcohol, control, NAPVSIPQ+SALLRSIPA then alcohol, or NAPVSIPQ+SALLRSIPA alone were evaluated for latency to find a hidden platform in the Morris water maze.
Summary · context
We used a well-characterized mouse model of fetal alcohol syndrome.
Summary · context
Pretreatment with NAPVSIPQ+SALLRSIPA (20 mug) or placebo was given 30 minutes before alcohol.
In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.
Report a problemFND-1615028108
09AnimalNot a test of Davunetide aloneAnimal study (in vivo)Efficacy outcome
In adult mouse offspring, prenatal NAPVSIPQ plus SALLRSIPA alone produced the shortest platform latency after learning commenced.
In plain wordsIn mice, prenatal NAPVSIPQ plus SALLRSIPA alone produced the shortest platform latency after learning started.
Peptide
Davunetide
Outcome
DecreasePlatform latency after learning commenced
Study
mousen: not reported in source
Fetal alcohol syndrome
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
Groups that were treated with only NAPVSIPQ+SALLRSIPA learned significantly earlier, with the shortest latency once learning commenced.
3 context sentences(design, population, supporting numbers)
Summary · context
To test spatial learning, adult offspring from litters that were treated with alcohol, control, NAPVSIPQ+SALLRSIPA then alcohol, or NAPVSIPQ+SALLRSIPA alone were evaluated for latency to find a hidden platform in the Morris water maze.
Summary · context
We used a well-characterized mouse model of fetal alcohol syndrome.
Summary · context
Pretreatment with NAPVSIPQ+SALLRSIPA (20 mug) or placebo was given 30 minutes before alcohol.
In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.
Report a problemFND-1615028109

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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