The importance of mini-puberty for fertility in cryptorchidism.

Hadziselimovic F, Zivkovic D, Bica DT, Emmons LR

The Journal of urology1 Oct 2005Cited by 93 (Europe PMC)

PMID16148647DOI10.1097/01.ju.0000181506.97839.b0PepBankPUB-16148647

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

01HumanNon-randomized trialEfficacy outcome
In boys with cryptorchidism, 17 HCG-treated patients had greater than 0.1 Ad/tbx, compared with 6 patients without previous hormonal treatment.
In plain wordsIn boys with cryptorchidism, 17 HCG-treated boys exceeded the spermatogonia threshold, compared with 6 boys without previous hormonal treatment.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseAd spermatogonia threshold
Study
n = 65
Comparator
Orchiopexy without previous hormonal treatment
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Measurements
Patients with greater than 0.1 Ad/tbx
17 patients
Group 1, HCG before orchiopexy
Patients with greater than 0.1 Ad/tbx
6 patients
Group 2, orchiopexy without previous hormonal treatment
Ad spermatogonia per tubular cross section threshold
> 0.1 Ad/tbx
Threshold exceeded by 17 group 1 patients and 6 group 2 patients
Ad spermatogonia per tubular cross section
≤ 0.1 Ad/tbx
Remaining group 1 patients
Source sentences
Summary
In group 1, 17 patients had greater than 0.1 Ad/tbx, and the remaining patients had 0.1 or less Ad/tbx.
2 context sentences(design, population, supporting numbers)
Summary · context
In group 2, 6 patients had greater than 0.1 Ad/tbx.
Summary · context
A total of 32 patients 1 to 7 years old were treated with human chorionic gonadotropin (HCG) to achieve epididymo-testicular descent before orchiopexy (group 1), and 33 patients underwent orchiopexy without previous hormonal treatment (group 2).
Report a problemFND-1614864701
02HumanNon-randomized trialEfficacy outcome
In boys with cryptorchidism, 35% responded inadequately to HCG stimulation.
In plain wordsIn boys with cryptorchidism, 35% responded inadequately to HCG stimulation.
Peptide
hCG (human chorionic gonadotropin)
Outcome
Not applicableInadequate HCG response
Study
n = 32
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Measurements
Inadequate response to HCG stimulation
35%
Boys with cryptorchidism receiving HCG stimulation
Source sentences
Summary
Of the boys with cryptorchidism 35% responded inadequately to HCG stimulation, while 10% did not respond.
1 context sentence(design, population, supporting numbers)
Summary · context
A total of 32 patients 1 to 7 years old were treated with human chorionic gonadotropin (HCG) to achieve epididymo-testicular descent before orchiopexy (group 1), and 33 patients underwent orchiopexy without previous hormonal treatment (group 2).
Report a problemFND-1614864702
03HumanNon-randomized trialEfficacy outcome
In boys with cryptorchidism, 10% did not respond to HCG stimulation.
In plain wordsIn boys with cryptorchidism, 10% did not respond to HCG stimulation.
Peptide
hCG (human chorionic gonadotropin)
Outcome
Not applicableAbsent HCG response
Study
n = 32
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Measurements
No response to HCG stimulation
10%
Boys with cryptorchidism receiving HCG stimulation
Source sentences
Summary
Of the boys with cryptorchidism 35% responded inadequately to HCG stimulation, while 10% did not respond.
1 context sentence(design, population, supporting numbers)
Summary · context
A total of 32 patients 1 to 7 years old were treated with human chorionic gonadotropin (HCG) to achieve epididymo-testicular descent before orchiopexy (group 1), and 33 patients underwent orchiopexy without previous hormonal treatment (group 2).
Report a problemFND-1614864703
04HumanNon-randomized trialOther
In boys with cryptorchidism and inadequate HCG responses, Ad spermatogonia differentiation was defective at 0.1 or less.
In plain wordsIn boys with cryptorchidism and inadequate HCG responses, sperm precursor differentiation was defective.
Peptide
hCG (human chorionic gonadotropin)
Outcome
Not applicableSpermatogonia differentiation with inadequate response
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Measurements
Ad spermatogonia differentiation
≤ 0.1 Ad/tbx
Suboptimal Leydig cell capacity with inadequate HCG response
Source sentences
Summary
Those patients with suboptimal Leydig cell capacity (and an inadequate response to HCG stimulation) had a defective Ad spermatogonia differentiation of 0.1 or less.
1 context sentence(design, population, supporting numbers)
Summary · context
A total of 32 patients 1 to 7 years old were treated with human chorionic gonadotropin (HCG) to achieve epididymo-testicular descent before orchiopexy (group 1), and 33 patients underwent orchiopexy without previous hormonal treatment (group 2).
Report a problemFND-1614864704

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.