A strong neuroprotective effect of the autonomous C-terminal peptide of IGF-1 Ec (MGF) in brain ischemia.

Dluzniewska J, Sarnowska A, Beresewicz M, Johnson I, Srai SK, Ramesh B, Goldspink G, Górecki DC, Zabłocka B

FASEB journal : official publication of the Federation of American Societies for Experimental Biology6 Sept 2005Cited by 104 (Europe PMC)

PMID16144956DOI10.1096/fj.05-3786fjePepBankPUB-16144956

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Mechanism
In gerbils with transient brain ischemia, ischemia increased expression of endogenous MGF in ischemia-resistant hippocampal neurons.
In plain wordsIn gerbils, the body's own MGF rose in brain cells that resist ischemia.
Peptide
MGF / PEG-MGF
Outcome
IncreaseEndogenous MGF expression after ischemia
Study
gerbiln: not reported in source
gerbil model of transient brain ischemia
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
In the same model, ischemia evoked increased expression of endogenous MGF in the ischemia-resistant hippocampal neurons, suggesting that the endogenous MGF might have an important neuroprotective function.
1 context sentence(design, population, supporting numbers)
Summary · context
The C-terminal peptide of mechano-growth factor (MGF), an alternatively spliced variant of insulin-like growth factor 1 (IGF-1), was found to function independently from the rest of the molecule and showed a neuroprotective effect in vivo and in vitro.
This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1614495602

Studies that did not test the peptide alone5

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

02AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Efficacy outcome
In gerbils with transient brain ischemia, the synthetic MGF C-terminal peptide gave very significant protection to vulnerable neurons.
In plain wordsIn gerbils, a synthetic piece of MGF protected vulnerable brain cells after a temporary loss of blood flow.
Peptide
MGF / PEG-MGF
Outcome
IncreaseNeuronal protection after transient brain ischemia
Study
gerbiln: not reported in source
gerbil model of transient brain ischemia
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
In vivo, in a gerbil model of transient brain ischemia, treatment with the synthetic MGF C-terminal peptide provided very significant protection to the vulnerable neurons.
1 context sentence(design, population, supporting numbers)
Summary · context
The C-terminal peptide of mechano-growth factor (MGF), an alternatively spliced variant of insulin-like growth factor 1 (IGF-1), was found to function independently from the rest of the molecule and showed a neuroprotective effect in vivo and in vitro.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-1614495601
03LabNot a test of MGF / PEG-MGF aloneEx vivo tissueEfficacy outcome
In an organotypic hippocampal culture model of neurodegeneration, the synthetic MGF C-terminal peptide was as potent as full-length IGF-1.
In plain wordsIn lab tests on brain tissue cultures, a synthetic piece of MGF protected as strongly as full-length IGF-1.
Peptide
MGF / PEG-MGF
Outcome
No significant changeNeuroprotective potency versus full-length IGF-1
Study
n: not reported in source
organotypic hippocampal culture model of neurodegeneration
Comparator
Full-length IGF-1
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
In an in vitro organotypic hippocampal culture model of neurodegeneration, the synthetic peptide was as potent as the full-length IGF-1
1 context sentence(design, population, supporting numbers)
Summary · context
The C-terminal peptide of mechano-growth factor (MGF), an alternatively spliced variant of insulin-like growth factor 1 (IGF-1), was found to function independently from the rest of the molecule and showed a neuroprotective effect in vivo and in vitro.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-1614495603
04LabNot a test of MGF / PEG-MGF aloneEx vivo tissueEfficacy outcome
In an organotypic hippocampal culture model, the effect of the synthetic MGF peptide lasted significantly longer than that of recombinant IGF-1.
In plain wordsIn lab tests on brain tissue cultures, the effect of a synthetic piece of MGF lasted longer than that of recombinant IGF-1.
Peptide
MGF / PEG-MGF
Outcome
IncreaseDuration of neuroprotective effect versus recombinant IGF-1
Study
n: not reported in source
organotypic hippocampal culture model of neurodegeneration
Comparator
Recombinant IGF-1
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
while its effect lasted significantly longer than that of recombinant IGF-1.
1 context sentence(design, population, supporting numbers)
Summary · context
The C-terminal peptide of mechano-growth factor (MGF), an alternatively spliced variant of insulin-like growth factor 1 (IGF-1), was found to function independently from the rest of the molecule and showed a neuroprotective effect in vivo and in vitro.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-1614495604
05LabNot a test of MGF / PEG-MGF aloneEx vivo tissueEfficacy outcome
In an organotypic hippocampal culture model, the MGF C-terminal peptide and IGF-1 showed an additive neuroprotective effect.
In plain wordsIn lab tests on brain tissue cultures, the MGF piece and IGF-1 together protected more than either alone.
Peptide
MGF / PEG-MGF
Outcome
IncreaseCombined neuroprotection of the two peptides
Study
n: not reported in source
organotypic hippocampal culture model of neurodegeneration
Comparator
Each peptide alone
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
While two peptides showed an additive effect
1 context sentence(design, population, supporting numbers)
Summary · context
The C-terminal peptide of mechano-growth factor (MGF), an alternatively spliced variant of insulin-like growth factor 1 (IGF-1), was found to function independently from the rest of the molecule and showed a neuroprotective effect in vivo and in vitro.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-1614495605
06LabNot a test of MGF / PEG-MGF aloneEx vivo tissueMechanism
In an organotypic hippocampal culture model, the neuroprotective action of the C-terminal MGF peptide was independent from the IGF-1 receptor.
In plain wordsIn lab tests on brain tissue cultures, the MGF piece protected cells without using the IGF-1 receptor.
Peptide
MGF / PEG-MGF
Outcome
Not applicableIGF-1 receptor dependence of neuroprotection
Study
n: not reported in source
organotypic hippocampal culture model of neurodegeneration
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
the neuroprotective action of the C-terminal MGF was independent from the IGF-1 receptor, indicating a new mode of action for this molecule.
1 context sentence(design, population, supporting numbers)
Summary · context
The C-terminal peptide of mechano-growth factor (MGF), an alternatively spliced variant of insulin-like growth factor 1 (IGF-1), was found to function independently from the rest of the molecule and showed a neuroprotective effect in vivo and in vitro.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-1614495606

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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