Skip to content

Study · Animal study (in vivo) · rattus norvegicus · 2005

11 results

Effects of low-dose, intermittent treatment with recombinant human parathyroid hormone (1-34) on chondrogenesis in a model of experimental fracture healing.

Nakazawa T, Nakajima A, Shiomi K, Moriya H, Einhorn TA, Yamazaki M

Bone6 Sept 2005Cited by 114 (Europe PMC)

PMID16143574 (opens in a new tab)DOI10.1016/j.bone.2005.06.013 (opens in a new tab)PepBankPUB-16143574
Publisher pagePubMedAsk about this study
Jump to 11 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats with fractures, rhPTH increased cartilage area 1.4-fold versus vehicle on day 14.

    In plain wordsIn rats with fractures, rhPTH increased cartilage area versus vehicle on day 14.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseCartilage area at day 14
    Study

    Rattus norvegicusn: not reported in source

    Sprague-Dawley rats with femoral fracture
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg daily · subcutaneous · 28 daysAs given in this study (Rattus norvegicus).

    Measurements

    Cartilage area
    1.4 fold
    versus control on day 14

    Source sentences

    Summary
    The results showed that, on day 14 after fracture, cartilage area in the PTH-treated group was significantly increased (1.4-fold) compared with the controls, but this increase was not observed at days 21 and 28.
    3 context sentences
    Summary · context
    Unilateral femoral fractures were produced in 2-month-old Sprague-Dawley rats.
    Summary · context
    Daily subcutaneous injections of 10 microg/kg of recombinant human PTH(1-34) [rhPTH(1-34)] were administered over a 28-day period of fracture healing.
    Summary · context
    Control animals were injected with vehicle solution (normal saline) alone.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with fractures, the cartilage area increase with rhPTH versus vehicle was absent on days 21 and 28.

    In plain wordsIn rats with fractures, rhPTH did not increase cartilage area versus vehicle on days 21 and 28.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeCartilage area at days 21 and 28
    Study

    Rattus norvegicusn: not reported in source

    Sprague-Dawley rats with femoral fracture
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg daily · subcutaneous · 28 daysAs given in this study (Rattus norvegicus).

    Source sentences

    Summary
    The results showed that, on day 14 after fracture, cartilage area in the PTH-treated group was significantly increased (1.4-fold) compared with the controls, but this increase was not observed at days 21 and 28.
    3 context sentences
    Summary · context
    Unilateral femoral fractures were produced in 2-month-old Sprague-Dawley rats.
    Summary · context
    Daily subcutaneous injections of 10 microg/kg of recombinant human PTH(1-34) [rhPTH(1-34)] were administered over a 28-day period of fracture healing.
    Summary · context
    Control animals were injected with vehicle solution (normal saline) alone.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with fractures, rhPTH increased mesenchymal cell proliferation versus vehicle during early chondrogenesis.

    In plain wordsIn rats with fractures, rhPTH increased cartilage precursor cell growth versus vehicle during early healing.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseMesenchymal cell proliferation
    Study

    Rattus norvegicusn: not reported in source

    Sprague-Dawley rats with femoral fracture
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg daily · subcutaneous · 28 daysAs given in this study (Rattus norvegicus).

    Source sentences

    Summary
    In the early stage of chondrogenesis (days 4-7), cell proliferation, expressed as the rate of proliferating cell nuclear antigen-positive cells, was increased in mesenchymal (chondroprogenitor) cells but not chondrocytes in the PTH-treated group compared with controls.
    3 context sentences
    Summary · context
    Unilateral femoral fractures were produced in 2-month-old Sprague-Dawley rats.
    Summary · context
    Daily subcutaneous injections of 10 microg/kg of recombinant human PTH(1-34) [rhPTH(1-34)] were administered over a 28-day period of fracture healing.
    Summary · context
    Control animals were injected with vehicle solution (normal saline) alone.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with fractures, rhPTH did not increase chondrocyte proliferation versus vehicle during early chondrogenesis.

    In plain wordsIn rats with fractures, rhPTH did not increase cartilage cell growth versus vehicle during early healing.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeChondrocyte proliferation during early chondrogenesis
    Study

    Rattus norvegicusn: not reported in source

    Sprague-Dawley rats with femoral fracture
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg daily · subcutaneous · 28 daysAs given in this study (Rattus norvegicus).

    Source sentences

    Summary
    In the early stage of chondrogenesis (days 4-7), cell proliferation, expressed as the rate of proliferating cell nuclear antigen-positive cells, was increased in mesenchymal (chondroprogenitor) cells but not chondrocytes in the PTH-treated group compared with controls.
    3 context sentences
    Summary · context
    Unilateral femoral fractures were produced in 2-month-old Sprague-Dawley rats.
    Summary · context
    Daily subcutaneous injections of 10 microg/kg of recombinant human PTH(1-34) [rhPTH(1-34)] were administered over a 28-day period of fracture healing.
    Summary · context
    Control animals were injected with vehicle solution (normal saline) alone.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with fractures, rhPTH increased SOX-9 expression 1.4-fold versus vehicle on day 4.

    In plain wordsIn rats with fractures, rhPTH increased SOX-9 gene expression versus vehicle during early healing.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseSOX-9 expression on day 4
    Study

    Rattus norvegicusn: not reported in source

    Sprague-Dawley rats with femoral fracture
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg daily · subcutaneous · 28 daysAs given in this study (Rattus norvegicus).

    Source sentences

    Summary
    In addition, gene expression of SOX-9 was up-regulated in the PTH-treated group on day 4 (1.4-fold), and this was accompanied by enhanced expression of pro-alpha1 (II) collagen (1.8-fold).
    3 context sentences
    Summary · context
    Unilateral femoral fractures were produced in 2-month-old Sprague-Dawley rats.
    Summary · context
    Daily subcutaneous injections of 10 microg/kg of recombinant human PTH(1-34) [rhPTH(1-34)] were administered over a 28-day period of fracture healing.
    Summary · context
    Control animals were injected with vehicle solution (normal saline) alone.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats with fractures, rhPTH enhanced pro-alpha1 (II) collagen expression 1.8-fold versus vehicle during early chondrogenesis.

    In plain wordsIn rats with fractures, rhPTH increased a cartilage collagen gene's expression versus vehicle during early healing.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreasePro-alpha1 (II) collagen expression
    Study

    Rattus norvegicusn: not reported in source

    Sprague-Dawley rats with femoral fracture
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg daily · subcutaneous · 28 daysAs given in this study (Rattus norvegicus).

    Source sentences

    Summary
    In addition, gene expression of SOX-9 was up-regulated in the PTH-treated group on day 4 (1.4-fold), and this was accompanied by enhanced expression of pro-alpha1 (II) collagen (1.8-fold).
    3 context sentences
    Summary · context
    Unilateral femoral fractures were produced in 2-month-old Sprague-Dawley rats.
    Summary · context
    Daily subcutaneous injections of 10 microg/kg of recombinant human PTH(1-34) [rhPTH(1-34)] were administered over a 28-day period of fracture healing.
    Summary · context
    Control animals were injected with vehicle solution (normal saline) alone.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats with fractures, cell proliferation did not differ significantly between rhPTH and vehicle after 14 days.

    In plain wordsIn rats with fractures, cell growth did not differ significantly between rhPTH and vehicle after 14 days.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeCell proliferation after 14 days
    Study

    Rattus norvegicusn: not reported in source

    Sprague-Dawley rats with femoral fracture
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg daily · subcutaneous · 28 daysAs given in this study (Rattus norvegicus).

    Source sentences

    Summary
    After 14 days, there were no significant differences between groups in either cell proliferation or the expression levels of cartilage differentiation-related genes (SOX-9, pro-alpha1 (II) collagen, pro-alpha1 (X) collagen and osteopontin).
    3 context sentences
    Summary · context
    Unilateral femoral fractures were produced in 2-month-old Sprague-Dawley rats.
    Summary · context
    Daily subcutaneous injections of 10 microg/kg of recombinant human PTH(1-34) [rhPTH(1-34)] were administered over a 28-day period of fracture healing.
    Summary · context
    Control animals were injected with vehicle solution (normal saline) alone.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In rats with fractures, SOX-9 expression did not differ significantly between rhPTH and vehicle after 14 days.

    In plain wordsIn rats with fractures, SOX-9 expression did not differ significantly between rhPTH and vehicle after 14 days.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeSOX-9 expression after 14 days
    Study

    Rattus norvegicusn: not reported in source

    Sprague-Dawley rats with femoral fracture
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg daily · subcutaneous · 28 daysAs given in this study (Rattus norvegicus).

    Source sentences

    Summary
    After 14 days, there were no significant differences between groups in either cell proliferation or the expression levels of cartilage differentiation-related genes (SOX-9, pro-alpha1 (II) collagen, pro-alpha1 (X) collagen and osteopontin).
    3 context sentences
    Summary · context
    Unilateral femoral fractures were produced in 2-month-old Sprague-Dawley rats.
    Summary · context
    Daily subcutaneous injections of 10 microg/kg of recombinant human PTH(1-34) [rhPTH(1-34)] were administered over a 28-day period of fracture healing.
    Summary · context
    Control animals were injected with vehicle solution (normal saline) alone.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In rats with fractures, pro-alpha1 (II) collagen expression did not differ significantly between rhPTH and vehicle after 14 days.

    In plain wordsIn rats with fractures, cartilage collagen expression did not differ significantly between rhPTH and vehicle after 14 days.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changePro-alpha1 (II) collagen expression after 14 days
    Study

    Rattus norvegicusn: not reported in source

    Sprague-Dawley rats with femoral fracture
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg daily · subcutaneous · 28 daysAs given in this study (Rattus norvegicus).

    Source sentences

    Summary
    After 14 days, there were no significant differences between groups in either cell proliferation or the expression levels of cartilage differentiation-related genes (SOX-9, pro-alpha1 (II) collagen, pro-alpha1 (X) collagen and osteopontin).
    3 context sentences
    Summary · context
    Unilateral femoral fractures were produced in 2-month-old Sprague-Dawley rats.
    Summary · context
    Daily subcutaneous injections of 10 microg/kg of recombinant human PTH(1-34) [rhPTH(1-34)] were administered over a 28-day period of fracture healing.
    Summary · context
    Control animals were injected with vehicle solution (normal saline) alone.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In rats with fractures, pro-alpha1 (X) collagen expression did not differ significantly between rhPTH and vehicle after 14 days.

    In plain wordsIn rats with fractures, pro-alpha1 (X) collagen expression did not differ significantly between rhPTH and vehicle after 14 days.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changePro-alpha1 (X) collagen expression after 14 days
    Study

    Rattus norvegicusn: not reported in source

    Sprague-Dawley rats with femoral fracture
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg daily · subcutaneous · 28 daysAs given in this study (Rattus norvegicus).

    Source sentences

    Summary
    After 14 days, there were no significant differences between groups in either cell proliferation or the expression levels of cartilage differentiation-related genes (SOX-9, pro-alpha1 (II) collagen, pro-alpha1 (X) collagen and osteopontin).
    3 context sentences
    Summary · context
    Unilateral femoral fractures were produced in 2-month-old Sprague-Dawley rats.
    Summary · context
    Daily subcutaneous injections of 10 microg/kg of recombinant human PTH(1-34) [rhPTH(1-34)] were administered over a 28-day period of fracture healing.
    Summary · context
    Control animals were injected with vehicle solution (normal saline) alone.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In rats with fractures, osteopontin expression did not differ significantly between rhPTH and vehicle after 14 days.

    In plain wordsIn rats with fractures, osteopontin expression did not differ significantly between rhPTH and vehicle after 14 days.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeOsteopontin expression after 14 days
    Study

    Rattus norvegicusn: not reported in source

    Sprague-Dawley rats with femoral fracture
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg daily · subcutaneous · 28 daysAs given in this study (Rattus norvegicus).

    Source sentences

    Summary
    After 14 days, there were no significant differences between groups in either cell proliferation or the expression levels of cartilage differentiation-related genes (SOX-9, pro-alpha1 (II) collagen, pro-alpha1 (X) collagen and osteopontin).
    3 context sentences
    Summary · context
    Unilateral femoral fractures were produced in 2-month-old Sprague-Dawley rats.
    Summary · context
    Daily subcutaneous injections of 10 microg/kg of recombinant human PTH(1-34) [rhPTH(1-34)] were administered over a 28-day period of fracture healing.
    Summary · context
    Control animals were injected with vehicle solution (normal saline) alone.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.