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Study · Animal study (in vivo) · monkey and rat · 2005

3 results

Novel long-acting crystal formulation of human growth hormone.

Govardhan C, Khalaf N, Jung CW, Simeone B, Higbie A, Qu S, Chemmalil L, Pechenov S, Basu SK, Margolin AL

Pharmaceutical research24 Aug 2005Cited by 49 (Europe PMC)

PMID16132358 (opens in a new tab)DOI10.1007/s11095-005-6021-x (opens in a new tab)PepBankPUB-16132358
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rats and monkeys, coated human growth hormone crystals provided release profiles over several days.

    In plain wordsIn rats and monkeys, coated growth hormone crystals released growth hormone over several days.

    Peptide
    HGH (somatotropin)
    Outcome
    Not applicableSustained release
    Study

    rats and monkeysn: not reported in source

    Outcome group
    Pharmacokinetics · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here we have demonstrated for the first time that crystals of human growth hormone coated with positively charged poly(arginine) allowed for in vivo pharmacokinetic release profiles of over several days in animal models.
    1 context sentence
    Summary · context
    The pharmacokinetics and pharmacodynamics of this poly(arginine)-coated human growth hormone crystalline formulation were determined in hypophysectomized rats and monkeys.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In hypophysectomized rats, weekly crystalline growth hormone had equivalent weight-gain efficacy to seven daily soluble injections.

    In plain wordsIn rats, weekly crystalline growth hormone produced equivalent weight gain to seven daily soluble injections.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeWeight gain
    Study

    ratn: not reported in source

    hypophysectomized rat
    Comparator
    seven daily soluble injections
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    once a week · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    The efficacy of this crystalline formulation injected subcutaneously once a week was found to be equivalent to seven daily soluble injections in the standard weight gain assay using the hypophysectomized rat model and in measurement of serum insulin-like growth factor in monkeys.
    1 context sentence
    Summary · context
    The pharmacokinetics and pharmacodynamics of this poly(arginine)-coated human growth hormone crystalline formulation were determined in hypophysectomized rats and monkeys.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In monkeys, weekly crystalline growth hormone had equivalent serum insulin-like growth factor efficacy to seven daily soluble injections.

    In plain wordsIn monkeys, weekly crystalline growth hormone produced equivalent insulin-like growth factor responses to seven daily soluble injections.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeSerum insulin-like growth factor
    Study

    monkeyn: not reported in source

    Comparator
    seven daily soluble injections
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    once a week · subcutaneousAs given in this study (monkey).

    Source sentences

    Summary
    The efficacy of this crystalline formulation injected subcutaneously once a week was found to be equivalent to seven daily soluble injections in the standard weight gain assay using the hypophysectomized rat model and in measurement of serum insulin-like growth factor in monkeys.
    1 context sentence
    Summary · context
    The pharmacokinetics and pharmacodynamics of this poly(arginine)-coated human growth hormone crystalline formulation were determined in hypophysectomized rats and monkeys.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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