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Study · Measured the body's own peptide · 2005

3 results

Oxytocin is associated with human trustworthiness.

Zak PJ, Kurzban R, Matzner WT

Hormones and behavior18 Aug 2005Cited by 224 (Europe PMC)

PMID16109416 (opens in a new tab)DOI10.1016/j.yhbeh.2005.07.009 (opens in a new tab)PepBankPUB-16109416
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelNon-randomized trialOther

    In human participants in a trust game, circulating oxytocin levels were higher in subjects who received a transfer reflecting an intention of trust than in those who received an unintentional transfer.

    In plain wordsIn people playing a trust game, the body's own oxytocin levels were higher after a trusting transfer than after an unintentional one.

    Peptide
    Oxytocin
    Outcome
    IncreaseCirculating oxytocin after intentional trust transfer
    Study

    n: not reported in source

    Comparator
    Unintentional monetary transfer of the same amount
    Outcome group
    Endogenous peptide levels · Mental health and mood

    Source sentences

    Summary
    We find that oxytocin levels are higher in subjects who receive a monetary transfer that reflects an intention of trust relative to an unintentional monetary transfer of the same amount.
    1 context sentence
    Summary · context
    This paper reports the results of an experiment to test this hypothesis, where trust and trustworthiness are measured using the sequential anonymous "trust game" with monetary payoffs.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelNon-randomized trialOther

    In human participants in a trust game, higher oxytocin levels were associated with trustworthy behavior (reciprocation of trust).

    In plain wordsIn people playing a trust game, higher natural oxytocin levels were linked to trustworthy behavior.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin level and trustworthy behavior
    Study

    n: not reported in source

    Outcome group
    Social behavior and cognition · Mental health and mood

    Source sentences

    Summary
    In addition, higher oxytocin levels are associated with trustworthy behavior (the reciprocation of trust).
    1 context sentence
    Summary · context
    This paper reports the results of an experiment to test this hypothesis, where trust and trustworthiness are measured using the sequential anonymous "trust game" with monetary payoffs.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelNon-randomized trialOther

    In human participants in a trust game, without intentionality of the transfer, both the oxytocin response and the behavioral response were extinguished.

    In plain wordsIn people playing a trust game, without a trusting intention the body's own oxytocin response and the behavior response disappeared.

    Peptide
    Oxytocin
    Outcome
    No significant changeOxytocin and behavioral responses without intentionality
    Study

    n: not reported in source

    Outcome group
    Social behavior and cognition · Mental health and mood

    Source sentences

    Summary
    Absent intentionality, both the oxytocin and behavioral responses are extinguished.
    1 context sentence
    Summary · context
    This paper reports the results of an experiment to test this hypothesis, where trust and trustworthiness are measured using the sequential anonymous "trust game" with monetary payoffs.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 1NCT03060031

Effects of Intranasal Oxytocin Administration on Social Influence Effects on Pain

University of Colorado, Bouldern = 5121 Jun 2017 to 1 Apr 2019

Pain

Trial pageClinicalTrials.govUpdated 25 Jun 2019

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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