Skip to content

Study · In vitro (cells) · rat · 2005

3 results

PolyADP-ribosylation is involved in neurotrophic activity.

Visochek L, Steingart RA, Vulih-Shultzman I, Klein R, Priel E, Gozes I, Cohen-Armon M

The Journal of neuroscience : the official journal of the Society for Neuroscience1 Aug 2005Cited by 70 (Europe PMC)

PMID16093393 (opens in a new tab)PMCIDPMC6725295 (opens in a new tab)DOI10.1523/jneurosci.0333-05.2005 (opens in a new tab)PepBankPUB-16093393
Read at sourcePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In rat cerebral cortical neurons, brief NAP exposure activated PARP-1.

    In plain wordsIn cells from rat cerebral cortex, brief NAP exposure activated PARP-1.

    Peptide
    Davunetide
    Outcome
    IncreasePARP-1 activation
    Study

    ratn: not reported in source

    Rat cerebral cortical neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    PARP-1 was activated in rat cerebral cortical neurons briefly exposed to NGF-related nerve growth factors and to the neuroprotective peptides NAP (the peptide NAPVSIPQ, derived from the activity-dependent neuroprotective protein ADNP) and ADNF-9 (the peptide SALLRSIPA, derived from the activity-depe…
  2. 02LabIn vitro (cells)Mechanism

    In differentiating pheochromocytoma 12 cells, polyADP-ribosylation was involved in NAP-induced neurite outgrowth.

    In plain wordsIn cells, polyADP-ribosylation was involved in NAP-induced nerve extension growth.

    Peptide
    Davunetide
    Outcome
    Not applicablePolyADP-ribosylation in NAP-induced neurite outgrowth
    Study

    n: not reported in source

    Differentiating pheochromocytoma 12 cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, polyADP-ribosylation was involved in the neurotrophic activity of NGF-induced and NAP-induced neurite outgrowth in differentiating pheochromocytoma 12 cells
  3. 03LabIn vitro (cells)Mechanism

    In neurons exposed to beta-amyloid, polyADP-ribosylation was involved in NAP neuroprotection.

    In plain wordsIn cells exposed to beta-amyloid, polyADP-ribosylation was involved in NAP protection.

    Peptide
    Davunetide
    Outcome
    Not applicablePolyADP-ribosylation in NAP neuroprotection
    Study

    n: not reported in source

    Neurons treated with beta-amyloid
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, polyADP-ribosylation was involved in the neurotrophic activity of NGF-induced and NAP-induced neurite outgrowth in differentiating pheochromocytoma 12 cells as well as in the neuroprotective activity of NAP in neurons treated with the Alzheimer's disease neurotoxin beta-amyloid.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.