Sexually dimorphic expression of oxytocin binding sites in forebrain and spinal cord of the rat.

Uhl-Bronner S, Waltisperger E, Martínez-Lorenzana G, Condes Lara M, Freund-Mercier MJ

Neuroscience1 Jan 2005Cited by 96 (Europe PMC)

PMID16084653DOI10.1016/j.neuroscience.2005.05.025PepBankPUB-16084653

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

01AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Other
In adult rats, males had higher oxytocin binding site densities than females in the ventromedial hypothalamic nucleus and the spinal cord dorsal horns.
In plain wordsIn rats, males had more oxytocin binding sites than females in two brain and spinal regions.
Peptide
Oxytocin
Outcome
IncreaseSex difference in oxytocin binding sites in VMH and spinal dorsal horn
Study
ratn: not reported in source
rat forebrain and spinal cord, film autoradiography
Comparator
Adult females
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Adult males had higher oxytocin binding site densities in the ventromedial hypothalamic nucleus and dorsal horns than females.
1 context sentence(design, population, supporting numbers)
Summary · context
Using film autoradiography, we quantified the density of oxytocin binding sites in the ventromedial hypothalamic nucleus, the medial and central nuclei of the amygdala, the medial bed nucleus of the stria terminalis and the spinal cord dorsal horns both in adult male and female rats, and during development.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1608465301
02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Other
In rats, no sex difference in oxytocin binding sites was found in gonadal steroid insensitive sites such as the central nucleus of the amygdala.
In plain wordsIn rats, males and females did not differ in oxytocin binding sites in the central amygdala.
Peptide
Oxytocin
Outcome
No significant changeSex difference in oxytocin binding sites in steroid-insensitive sites
Study
ratn: not reported in source
rat forebrain and spinal cord, film autoradiography
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Data showed a sexual dimorphism in the expression of oxytocin binding sites in the spinal cord dorsal horns and in restricted areas of the forebrain that are sensitive to gonadal steroids such as the ventromedial hypothalamic nucleus, but not in gonadal steroid insensitive sites such as the central…
1 context sentence(design, population, supporting numbers)
Summary · context
Using film autoradiography, we quantified the density of oxytocin binding sites in the ventromedial hypothalamic nucleus, the medial and central nuclei of the amygdala, the medial bed nucleus of the stria terminalis and the spinal cord dorsal horns both in adult male and female rats, and during development.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1608465302
03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Other
In rats, the sex difference in oxytocin binding sites required perinatal testosterone in the forebrain but not in the dorsal horn.
In plain wordsIn rats, early-life testosterone was needed for the male-female difference in the brain but not in the spinal cord.
Peptide
Oxytocin
Outcome
MixedRole of perinatal testosterone in the sex difference
Study
ratn: not reported in source
rat forebrain and spinal cord, film autoradiography
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
In the forebrain, but not in the dorsal horn, this sexual difference required a perinatal exposure to testosterone.
1 context sentence(design, population, supporting numbers)
Summary · context
Using film autoradiography, we quantified the density of oxytocin binding sites in the ventromedial hypothalamic nucleus, the medial and central nuclei of the amygdala, the medial bed nucleus of the stria terminalis and the spinal cord dorsal horns both in adult male and female rats, and during development.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1608465303
04AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Other
In rats, neonatal castration abolished the sex difference in oxytocin binding sites only in the ventromedial hypothalamic nucleus, not in the dorsal horn.
In plain wordsIn rats, castration at birth removed the male-female difference in one brain region but not in the spinal cord.
Peptide
Oxytocin
Outcome
MixedNeonatal castration effect on sex difference
Study
ratn: not reported in source
rat forebrain and spinal cord, film autoradiography
Comparator
Intact males
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Neonatal castration only abolished the sexual difference in the ventromedial hypothalamic nucleus of adults, but not in the dorsal horn.
1 context sentence(design, population, supporting numbers)
Summary · context
Using film autoradiography, we quantified the density of oxytocin binding sites in the ventromedial hypothalamic nucleus, the medial and central nuclei of the amygdala, the medial bed nucleus of the stria terminalis and the spinal cord dorsal horns both in adult male and female rats, and during development.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1608465304
05AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Other
In female rats, a single neonatal testosterone injection significantly increased oxytocin binding site density in the ventromedial hypothalamic nucleus, medial amygdala and medial bed nucleus of the stria terminalis.
In plain wordsIn female rats, one testosterone injection after birth raised the number of oxytocin binding sites in three brain regions.
Peptide
Oxytocin
Outcome
IncreaseNeonatal testosterone effect on oxytocin binding sites in females
Study
ratn: not reported in source
rat forebrain and spinal cord, film autoradiography
Comparator
Untreated females
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Furthermore, females that received a single injection of testosterone 1 day after birth showed significant increases in the density of oxytocin binding sites in the ventromedial hypothalamic nucleus, medial nucleus of the amygdala and medial bed nucleus of the stria terminalis.
1 context sentence(design, population, supporting numbers)
Summary · context
Using film autoradiography, we quantified the density of oxytocin binding sites in the ventromedial hypothalamic nucleus, the medial and central nuclei of the amygdala, the medial bed nucleus of the stria terminalis and the spinal cord dorsal horns both in adult male and female rats, and during development.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1608465305

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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:50 UTC
First added · source update from Europe PMC

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