Decreased distribution of nitric oxide synthase and vasoactive intestinal polypeptide positive nerve cells in the sphincter of Oddi in humans with pancreatobiliary diseases.

Zhang M, Shimojo H, Ehara T, Shigematsu H

Archives of histology and cytology1 Jun 2005Cited by 3 (Europe PMC)

PMID16079458DOI10.1679/aohc.68.121PepBankPUB-16079458

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In autopsy specimens, a lower proportion of sphincter of Oddi nerve cells was VIP positive in humans with pancreatobiliary diseases (32%) than in controls (54%).
In plain wordsIn autopsy samples, fewer sphincter of Oddi nerve cells made the body's own VIP in people with pancreatobiliary disease than in people without it.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseVIP-positive myenteric nerve cells in the sphincter of Oddi, disease versus control
Study
n = 18
Comparator
Cases without pancreatobiliary diseases
Outcome group
Endogenous peptide levels · Gastrointestinal
Measurements
VIP-positive nerve cells
54%
sphincter of Oddi, control group
VIP-positive nerve cells
32%
sphincter of Oddi, disease group
Source sentences
Summary
In the sphincter of Oddi of the control group, approximately 47% of the myenteric nerve cells were NOS positive, whereas 54% were VIP positive.
3 context sentences(design, population, supporting numbers)
Summary · context
In contrast, 11% of the nerve cells in the sphincter of Oddi of the disease group were NOS positive while 32% were VIP positive.
Summary · context
The lower proportion of NOS positive or VIP positive nerve cells of the disease group may suggest an inadequacy of the sphincter of Oddi to relax.
Summary · context
Specimens from autopsies included 11 cases with pancreatobiliary diseases and 7 cases without such diseases.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1607945801
02HumanEndogenous levelObservational studyOther
In the duodenal myenteric plexus of control autopsy cases, 40% of nerve cells were VIP positive.
In plain wordsIn autopsy samples from people without pancreatobiliary disease, 40% of duodenal nerve cells made the body's own VIP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableVIP-positive nerve cells in the duodenal myenteric plexus of controls
Study
n = 7
Outcome group
Endogenous peptide levels · Gastrointestinal
Measurements
VIP-positive nerve cells
40%
duodenal myenteric plexus, control group
Source sentences
Summary
Within the duodenal myenteric plexus of the control group, 35% of all nerve cells were NOS positive while 40% was VIP positive; among them, 23% of the NOS positive cells were VIP positive.
1 context sentence(design, population, supporting numbers)
Summary · context
Specimens from autopsies included 11 cases with pancreatobiliary diseases and 7 cases without such diseases.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1607945802
03HumanEndogenous levelObservational studyOther
In the sphincter of Oddi of control autopsy cases, 21% of NOS-positive nerve cells were also VIP positive.
In plain wordsIn autopsy samples from people without disease, about one in five nitric oxide-making sphincter of Oddi nerve cells also made the body's own VIP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableVIP-positive proportion of NOS-positive nerve cells in the sphincter of Oddi of controls
Study
n = 7
Outcome group
Endogenous peptide levels · Gastrointestinal
Measurements
NOS-positive cells also VIP positive
21%
sphincter of Oddi, control group
Source sentences
Summary
Of the NOS positive nerve cells, 21% were also VIP positive.
1 context sentence(design, population, supporting numbers)
Summary · context
Specimens from autopsies included 11 cases with pancreatobiliary diseases and 7 cases without such diseases.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1607945803
04HumanEndogenous levelObservational studyOther
In the duodenal myenteric plexus of control autopsy cases, 23% of NOS-positive nerve cells were VIP positive.
In plain wordsIn autopsy samples from people without disease, about one in four nitric oxide-making duodenal nerve cells also made the body's own VIP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableVIP-positive proportion of NOS-positive nerve cells in the duodenal myenteric plexus of controls
Study
n = 7
Outcome group
Endogenous peptide levels · Gastrointestinal
Measurements
NOS-positive cells also VIP positive
23%
duodenal myenteric plexus, control group
Source sentences
Summary
among them, 23% of the NOS positive cells were VIP positive.
1 context sentence(design, population, supporting numbers)
Summary · context
Specimens from autopsies included 11 cases with pancreatobiliary diseases and 7 cases without such diseases.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1607945804

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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