Overexpression of des(1-3) insulin-like growth factor 1 in the mammary glands of transgenic mice delays the loss of milk production with prolonged lactation.

Hadsell DL, Torres DT, Lawrence NA, George J, Parlow AF, Lee AV, Fiorotto ML

Biology of reproduction3 Aug 2005Cited by 15 (Europe PMC)

PMID16079306DOI10.1095/biolreprod.105.043992PepBankPUB-16079306

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone9

In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 DES (des(1-3)IGF-I).

01AnimalNot a test of IGF-1 DES (des(1-3)IGF-I) aloneAnimal study (in vivo)Mechanism
In WAP-DES mice, lactational capacity declined more slowly during prolonged lactation than in control mice.
In plain wordsIn mice, des(1‑3)IGF1 gene overexpression slowed the loss of milk production compared with control mice.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
DecreaseRate of decline in lactational capacity
Study
mousen: not reported in source
WAP-DES transgenic mice during prolonged lactation
Comparator
Nontransgenic control mice
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Slower rate of decline
40%
WAP-DES versus control mice
Source sentences
Summary
However, the rate of decline was 40% slower in WAP-DES mice.
2 context sentences(design, population, supporting numbers)
Summary · context
Over time, lactational capacity and mammary development declined in both WAP-DES and control mice.
Summary · context
The present study tested the hypothesis that overexpressed des(1-3)IGF1 would delay the loss of milk production during prolonged lactation. Accordingly, we examined lactational performance in WAP-DES mice by artificially prolonging lactation with continual litter cross-fostering.
In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).
Report a problemFND-1607930601
02AnimalNot a test of IGF-1 DES (des(1-3)IGF-I) aloneAnimal study (in vivo)Mechanism
In prolonged lactation, mammary cell apoptosis increased in both WAP-DES and control mice without a difference between genotypes.
In plain wordsIn mice, mammary cell death increased during prolonged milk production, with no difference between altered and control mice.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
No significant changeMammary cell apoptosis
Study
mousen: not reported in source
WAP-DES transgenic mice during prolonged lactation
Comparator
Nontransgenic control mice
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Apoptosis increase
3 fold
both groups during prolonged lactation
Source sentences
Summary
Mammary cell apoptosis increased by 3-fold in both groups during prolonged lactation but was not different between genotypes.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study tested the hypothesis that overexpressed des(1-3)IGF1 would delay the loss of milk production during prolonged lactation. Accordingly, we examined lactational performance in WAP-DES mice by artificially prolonging lactation with continual litter cross-fostering.
In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).
Report a problemFND-1607930602
03AnimalNot a test of IGF-1 DES (des(1-3)IGF-I) aloneAnimal study (in vivo)Mechanism
In WAP-DES mice, plasma murine IGF1 concentrations were decreased during prolonged lactation.
In plain wordsIn mice, natural mouse IGF1 blood levels were lower with des(1‑3)IGF1 gene overexpression during prolonged milk production.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
DecreasePlasma murine IGF1
Study
mousen: not reported in source
WAP-DES transgenic mice during prolonged lactation
Comparator
Nontransgenic control mice
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Plasma concentrations of murine IGF1 were decreased in WAP-DES mice, while those of the transgenic human IGF1 were elevated during prolonged lactation.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study tested the hypothesis that overexpressed des(1-3)IGF1 would delay the loss of milk production during prolonged lactation. Accordingly, we examined lactational performance in WAP-DES mice by artificially prolonging lactation with continual litter cross-fostering.
In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).
Report a problemFND-1607930603
04AnimalNot a test of IGF-1 DES (des(1-3)IGF-I) aloneAnimal study (in vivo)Mechanism
In WAP-DES mice, plasma transgenic human IGF1 concentrations were elevated during prolonged lactation.
In plain wordsIn mice, human IGF1 blood levels from the introduced gene were elevated during prolonged milk production.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
IncreasePlasma transgenic human IGF1
Study
mousen: not reported in source
WAP-DES transgenic mice during prolonged lactation
Comparator
Nontransgenic control mice
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Plasma concentrations of murine IGF1 were decreased in WAP-DES mice, while those of the transgenic human IGF1 were elevated during prolonged lactation.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study tested the hypothesis that overexpressed des(1-3)IGF1 would delay the loss of milk production during prolonged lactation. Accordingly, we examined lactational performance in WAP-DES mice by artificially prolonging lactation with continual litter cross-fostering.
In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).
Report a problemFND-1607930604
05AnimalNot a test of IGF-1 DES (des(1-3)IGF-I) aloneAnimal study (in vivo)Mechanism
In WAP-DES mice, mammary IGF1 receptor phosphorylation increased only during prolonged lactation.
In plain wordsIn mice, des(1‑3)IGF1 gene overexpression increased mammary IGF1 receptor phosphorylation only during prolonged milk production.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
IncreaseMammary IGF1 receptor phosphorylation
Study
mousen: not reported in source
WAP-DES transgenic mice during prolonged lactation
Comparator
Nontransgenic control mice
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
Phosphorylation of the mammary IGF1 receptor was increased in the WAP-DES mice, but only during prolonged lactation.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study tested the hypothesis that overexpressed des(1-3)IGF1 would delay the loss of milk production during prolonged lactation. Accordingly, we examined lactational performance in WAP-DES mice by artificially prolonging lactation with continual litter cross-fostering.
In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).
Report a problemFND-1607930605
06AnimalNot a test of IGF-1 DES (des(1-3)IGF-I) aloneAnimal study (in vivo)Mechanism
During prolonged lactation, plasma prolactin remained high in WAP-DES mice but decreased in nontransgenic mice.
In plain wordsIn mice, prolactin stayed high with des(1‑3)IGF1 gene overexpression but fell in control mice during prolonged milk production.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
IncreasePlasma prolactin
Study
mousen: not reported in source
WAP-DES transgenic mice during prolonged lactation
Comparator
Nontransgenic control mice
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Plasma prolactin decreased with prolonged lactation in nontransgenic mice but remained high in WAP-DES mice.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study tested the hypothesis that overexpressed des(1-3)IGF1 would delay the loss of milk production during prolonged lactation. Accordingly, we examined lactational performance in WAP-DES mice by artificially prolonging lactation with continual litter cross-fostering.
In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).
Report a problemFND-1607930606
07AnimalNot a test of IGF-1 DES (des(1-3)IGF-I) aloneAnimal study (in vivo)Mechanism
During prolonged lactation, WAP-DES mice maintained higher body mass than control mice.
In plain wordsIn mice, des(1‑3)IGF1 gene overexpression maintained higher body weight than controls during prolonged milk production.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
IncreaseBody mass
Study
mousen: not reported in source
WAP-DES transgenic mice during prolonged lactation
Comparator
Nontransgenic control mice
Outcome group
Body weight · Metabolic and weight
Source sentences
Summary
The WAP-DES mice maintained a higher body mass and a greater lean body mass during prolonged lactation.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study tested the hypothesis that overexpressed des(1-3)IGF1 would delay the loss of milk production during prolonged lactation. Accordingly, we examined lactational performance in WAP-DES mice by artificially prolonging lactation with continual litter cross-fostering.
In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).
Report a problemFND-1607930607
08AnimalNot a test of IGF-1 DES (des(1-3)IGF-I) aloneAnimal study (in vivo)Mechanism
During prolonged lactation, WAP-DES mice maintained greater lean body mass than control mice.
In plain wordsIn mice, des(1‑3)IGF1 gene overexpression maintained more lean body mass than controls during prolonged milk production.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
IncreaseLean body mass
Study
mousen: not reported in source
WAP-DES transgenic mice during prolonged lactation
Comparator
Nontransgenic control mice
Outcome group
Body weight · Metabolic and weight
Source sentences
Summary
The WAP-DES mice maintained a higher body mass and a greater lean body mass during prolonged lactation.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study tested the hypothesis that overexpressed des(1-3)IGF1 would delay the loss of milk production during prolonged lactation. Accordingly, we examined lactational performance in WAP-DES mice by artificially prolonging lactation with continual litter cross-fostering.
In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).
Report a problemFND-1607930608
09AnimalNot a test of IGF-1 DES (des(1-3)IGF-I) aloneAnimal study (in vivo)Mechanism
During prolonged lactation, mammary development declined over time in both WAP-DES and control mice.
In plain wordsIn mice, mammary development declined over time in both des(1‑3)IGF1 transgenic mice and control mice.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
DecreaseMammary development during prolonged lactation
Study
mousen: not reported in source
WAP-DES transgenic mice and control mice during prolonged lactation
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Over time, lactational capacity and mammary development declined in both WAP-DES and control mice.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study tested the hypothesis that overexpressed des(1-3)IGF1 would delay the loss of milk production during prolonged lactation. Accordingly, we examined lactational performance in WAP-DES mice by artificially prolonging lactation with continual litter cross-fostering.
In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).
Report a problemFND-1607930609

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 2
21 Oct 2026, 13:52 UTC
Study data updated · source update from Europe PMC
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

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Overexpression of des(1-3) insulin-like growth factor 1 in the mammary glands of transgenic mice delays the loss of milk production with prolonged lactation.

Summary

Results from this study9

Studies that did not test the peptide alone9

Version history

Subjects

Publication types

MeSH terms