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Study · Randomized controlled trial · n = 59 · 2005

10 results

A randomized, parallel, comparative study of the efficacy and safety of nafarelin versus danazol in the treatment of endometriosis in Taiwan.

Cheng MH, Yu BK, Chang SP, Wang PH

Journal of the Chinese Medical Association : JCMA1 Jul 2005Cited by 15 (Europe PMC)

PMID16038370 (opens in a new tab)DOI10.1016/s1726-4901(09)70166-2 (opens in a new tab)PepBankPUB-16038370
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. 10 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In Taiwanese women with endometriosis, laparoscopy scores did not differ significantly between nafarelin and danazol at 90 days.

    In plain wordsLaparoscopy scores were similar with nafarelin and danazol at 90 days.

    Peptide
    Nafarelin
    Outcome
    No significant changeLaparoscopy score at 90 days
    Study

    n = 59

    Comparator
    Danazol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 90 daysAs given in this study (human).

    Source sentences

    Summary
    No significant differences were noted in efficacy endpoints between nafarelin and danazol regarding LS and TSSS at 90 and 180 days of treatment.
    1 context sentence
    Summary · context
    Fifty-nine women with laparoscopically and pathologically confirmed endometriosis were randomized to receive nafarelin or danazol for 180 days.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In Taiwanese women with endometriosis, laparoscopy scores did not differ significantly between nafarelin and danazol at 180 days.

    In plain wordsLaparoscopy scores were similar with nafarelin and danazol at 180 days.

    Peptide
    Nafarelin
    Outcome
    No significant changeLaparoscopy score at 180 days
    Study

    n = 59

    Comparator
    Danazol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 180 daysAs given in this study (human).

    Source sentences

    Summary
    No significant differences were noted in efficacy endpoints between nafarelin and danazol regarding LS and TSSS at 90 and 180 days of treatment.
    1 context sentence
    Summary · context
    Fifty-nine women with laparoscopically and pathologically confirmed endometriosis were randomized to receive nafarelin or danazol for 180 days.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In Taiwanese women with endometriosis, total symptom severity scores did not differ significantly between nafarelin and danazol at 90 days.

    In plain wordsSymptom severity was similar with nafarelin and danazol at 90 days.

    Peptide
    Nafarelin
    Outcome
    No significant changeSymptom severity at 90 days
    Study

    n = 59

    Comparator
    Danazol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 90 daysAs given in this study (human).

    Source sentences

    Summary
    No significant differences were noted in efficacy endpoints between nafarelin and danazol regarding LS and TSSS at 90 and 180 days of treatment.
    1 context sentence
    Summary · context
    Fifty-nine women with laparoscopically and pathologically confirmed endometriosis were randomized to receive nafarelin or danazol for 180 days.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In Taiwanese women with endometriosis, total symptom severity scores did not differ significantly between nafarelin and danazol at 180 days.

    In plain wordsSymptom severity was similar with nafarelin and danazol at 180 days.

    Peptide
    Nafarelin
    Outcome
    No significant changeSymptom severity at 180 days
    Study

    n = 59

    Comparator
    Danazol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 180 daysAs given in this study (human).

    Source sentences

    Summary
    No significant differences were noted in efficacy endpoints between nafarelin and danazol regarding LS and TSSS at 90 and 180 days of treatment.
    1 context sentence
    Summary · context
    Fifty-nine women with laparoscopically and pathologically confirmed endometriosis were randomized to receive nafarelin or danazol for 180 days.
  5. 05HumanRandomized controlled trialSafety outcome

    In Taiwanese women with endometriosis, overall adverse event incidence did not differ significantly between nafarelin and danazol, except laboratory-related events.

    In plain wordsOverall adverse event rates were similar with nafarelin and danazol, except laboratory-related events.

    Peptide
    Nafarelin
    Outcome
    No significant changeOverall adverse events
    Study

    n = 59

    Comparator
    Danazol
    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated · 180 daysAs given in this study (human).

    Source sentences

    Summary
    No significant difference was observed between the 2 groups regarding the overall incidence of AEs, except for laboratory-related AEs.
    1 context sentence
    Summary · context
    Fifty-nine women with laparoscopically and pathologically confirmed endometriosis were randomized to receive nafarelin or danazol for 180 days.
  6. 06HumanRandomized controlled trialSafety outcome

    In Taiwanese women with endometriosis, nafarelin tended to affect aspartate transaminase less than danazol.

    In plain wordsNafarelin tended to affect a liver enzyme less than danazol.

    Peptide
    Nafarelin
    Outcome
    Direction not reportedAspartate transaminase changes
    Study

    n = 59

    Comparator
    Danazol
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated · 180 daysAs given in this study (human).

    Source sentences

    Summary
    However, nafarelin tended to have less impact than danazol on aspartate transaminase and alanine transaminase, and nafarelin was better tolerated than danazol regarding changes in lipid profiles.
    1 context sentence
    Summary · context
    Fifty-nine women with laparoscopically and pathologically confirmed endometriosis were randomized to receive nafarelin or danazol for 180 days.
  7. 07HumanRandomized controlled trialSafety outcome

    In Taiwanese women with endometriosis, nafarelin tended to affect alanine transaminase less than danazol.

    In plain wordsNafarelin tended to affect a liver enzyme less than danazol.

    Peptide
    Nafarelin
    Outcome
    Direction not reportedAlanine transaminase changes
    Study

    n = 59

    Comparator
    Danazol
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated · 180 daysAs given in this study (human).

    Source sentences

    Summary
    However, nafarelin tended to have less impact than danazol on aspartate transaminase and alanine transaminase, and nafarelin was better tolerated than danazol regarding changes in lipid profiles.
    1 context sentence
    Summary · context
    Fifty-nine women with laparoscopically and pathologically confirmed endometriosis were randomized to receive nafarelin or danazol for 180 days.
  8. 08HumanRandomized controlled trialSafety outcome

    In Taiwanese women with endometriosis, nafarelin was better tolerated than danazol regarding lipid profile changes.

    In plain wordsNafarelin affected lipid profiles more favorably than danazol.

    Peptide
    Nafarelin
    Outcome
    Direction not reportedLipid profile tolerability
    Study

    n = 59

    Comparator
    Danazol
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated · 180 daysAs given in this study (human).

    Source sentences

    Summary
    However, nafarelin tended to have less impact than danazol on aspartate transaminase and alanine transaminase, and nafarelin was better tolerated than danazol regarding changes in lipid profiles.
    1 context sentence
    Summary · context
    Fifty-nine women with laparoscopically and pathologically confirmed endometriosis were randomized to receive nafarelin or danazol for 180 days.
  9. 09HumanNon-randomized trialEfficacy outcome

    In Taiwanese women with endometriosis, nafarelin satisfactorily resolved pelvic tenderness, induration, pelvic pain, dysmenorrhea and dyspareunia.

    In plain wordsNafarelin improved the reported endometriosis manifestations in Taiwanese women.

    Peptide
    Nafarelin
    Outcome
    DecreaseEndometriosis manifestations
    Study

    n: not reported in source

    Comparator
    Baseline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 180 daysAs given in this study (human).

    Source sentences

    Summary
    Both nafarelin and danazol satisfactorily resolved pelvic tenderness, induration, pelvic pain, dysmenorrhea and dyspareunia.
    1 context sentence
    Summary · context
    Fifty-nine women with laparoscopically and pathologically confirmed endometriosis were randomized to receive nafarelin or danazol for 180 days.
  10. 10HumanNon-randomized trialSafety outcome

    In Taiwanese women with endometriosis, nafarelin had little or no effect on hematologic parameters.

    In plain wordsNafarelin had little or no effect on blood parameters in women with endometriosis.

    Peptide
    Nafarelin
    Outcome
    Direction not reportedHematologic parameters
    Study

    n: not reported in source

    Comparator
    Baseline
    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated · 180 daysAs given in this study (human).

    Source sentences

    Summary
    Both treatments had little or no effect on hematologic parameters.
    1 context sentence
    Summary · context
    Fifty-nine women with laparoscopically and pathologically confirmed endometriosis were randomized to receive nafarelin or danazol for 180 days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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