Skip to content

Study · Animal study (in vivo) · rat · 2005

3 results

Physiologically based pharmacokinetic model for pralmorelin hydrochloride in rats.

Nasu R, Kumagai Y, Kogetsu H, Tsujimoto M, Ohtani H, Sawada Y

Drug metabolism and disposition: the biological fate of chemicals20 Jul 2005Cited by 6 (Europe PMC)

PMID16033952 (opens in a new tab)DOI10.1124/dmd.104.001040 (opens in a new tab)PepBankPUB-16033952
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In Sprague-Dawley rats, plasma concentrations of pralmorelin declined rapidly in a biexponential manner after intravenous bolus.

    In plain wordsIn rats, pralmorelin blood levels dropped fast in two phases after an injection into a vein.

    Peptide
    GHRP-2
    Outcome
    Not applicablePlasma concentration time course
    Study

    ratn = 24

    Sprague-Dawley rats
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    3 mg/kg · intravenous bolusAs given in this study (rat).

    Source sentences

    Summary
    Plasma concentrations of pralmorelin declined rapidly in a biexponential manner.
    1 context sentence
    Summary · context
    Pralmorelin (3 mg/kg) was administered intravenously to 24 Sprague-Dawley rats.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In Sprague-Dawley rats, 80% of the pralmorelin dose was recovered unchanged in bile within 1 h.

    In plain wordsIn rats, most of the pralmorelin dose left unchanged in bile within an hour.

    Peptide
    GHRP-2
    Outcome
    Not applicableBiliary excretion
    Study

    ratn = 24

    Sprague-Dawley rats
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    3 mg/kg · intravenous bolusAs given in this study (rat).

    Measurements

    Biliary recovery of unchanged dose
    80%
    within 1 h

    Source sentences

    Summary
    Biliary excretion of pralmorelin was so rapid that 80% of the dose was recovered unchanged in the bile within 1 h after administration.
    1 context sentence
    Summary · context
    Pralmorelin (3 mg/kg) was administered intravenously to 24 Sprague-Dawley rats.
  3. 03AnimalAnimal study (in vivo)Pharmacokinetics

    In Sprague-Dawley rats, distribution of pralmorelin into liver was blood flow-limited and was permeability-limited in all other tissues.

    In plain wordsIn rats, pralmorelin entry into the liver depended on blood flow. In other tissues it depended on how easily it crossed membranes.

    Peptide
    GHRP-2
    Outcome
    Not applicableTissue distribution
    Study

    ratn = 24

    Sprague-Dawley rats
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    3 mg/kg · intravenous bolusAs given in this study (rat).

    Source sentences

    Summary
    They revealed that the distribution of pralmorelin into liver was blood flow-limited, and its distribution was permeability-limited in all other tissues.
    1 context sentence
    Summary · context
    Pralmorelin (3 mg/kg) was administered intravenously to 24 Sprague-Dawley rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.