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Study · In vitro (cells) · neisseria meningitidis · 2005

2 results

Cationic antimicrobial peptide resistance in Neisseria meningitidis.

Tzeng YL, Ambrose KD, Zughaier S, Zhou X, Miller YK, Shafer WM, Stephens DS

Journal of bacteriology1 Aug 2005Cited by 188 (Europe PMC)

PMID16030233 (opens in a new tab)PMCIDPMC1196002 (opens in a new tab)DOI10.1128/jb.187.15.5387-5396.2005 (opens in a new tab)PepBankPUB-16030233
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In Neisseria meningitidis, mutations within the mtrD gene increased susceptibility to human LL‑37.

    In plain wordsIn lab tests, meningococcal bacteria with a changed mtrD gene were more easily killed by LL‑37.

    Peptide
    LL-37
    Outcome
    IncreaseMeningococcal susceptibility to LL-37, mtrD mutants
    Study

    Neisseria meningitidisn: not reported in source

    Meningococcal strain NMB mutants
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mutations within the mtrD or lptA genes also increased meningococcal susceptibility to two structurally unrelated CAMPs, human LL-37 and protegrin-1.
    1 context sentence
    Summary · context
    To ascertain the mechanisms by which meningococci resist PxB, mutants that displayed increased sensitivity (> or =4-fold) to PxB were identified from a library of mariner transposon mutants generated in a meningococcal strain, NMB.
  2. 02LabIn vitro (cells)Activity measurement

    In Neisseria meningitidis, mutations within the lptA gene increased susceptibility to human LL‑37.

    In plain wordsIn lab tests, meningococcal bacteria with a changed lptA gene were more easily killed by LL‑37.

    Peptide
    LL-37
    Outcome
    IncreaseMeningococcal susceptibility to LL-37, lptA mutants
    Study

    Neisseria meningitidisn: not reported in source

    Meningococcal strain NMB mutants
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mutations within the mtrD or lptA genes also increased meningococcal susceptibility to two structurally unrelated CAMPs, human LL-37 and protegrin-1.
    1 context sentence
    Summary · context
    To ascertain the mechanisms by which meningococci resist PxB, mutants that displayed increased sensitivity (> or =4-fold) to PxB were identified from a library of mariner transposon mutants generated in a meningococcal strain, NMB.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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