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Study · Animal study (in vivo) · rat · 2005

9 results

Ghrelin receptor agonist GHRP-2 prevents arthritis-induced increase in E3 ubiquitin-ligating enzymes MuRF1 and MAFbx gene expression in skeletal muscle.

Granado M, Priego T, Martín AI, Villanúa MA, López-Calderón A

American journal of physiology. Endocrinology and metabolism19 Jul 2005Cited by 46 (Europe PMC)

PMID16030067 (opens in a new tab)DOI10.1152/ajpendo.00109.2005 (opens in a new tab)PepBankPUB-16030067
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with adjuvant-induced arthritis, GHRP‑2 for 8 days prevented the arthritis-induced rise in muscle MuRF1 gene expression.

    In plain wordsIn rats with arthritis, GHRP‑2 stopped the rise in a muscle-wasting gene called MuRF1.

    Peptide
    GHRP-2
    Outcome
    DecreaseMuscle MuRF1 gene expression
    Study

    ratn: not reported in source

    adjuvant-induced arthritis
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated · 8 daysAs given in this study (rat).

    Source sentences

    Summary
    Administration of GHRP-2 for 8 days prevented the arthritis-induced increase in muscular MuRF1
    2 context sentences
    Summary · context
    We also studied whether the synthetic ghrelin receptor agonist, growth hormone releasing peptide-2 (GHRP-2), was able to prevent arthritis-induced changes in the skeletal muscle.
    Summary · context
    Administration of GHRP-2 for 8 days prevented the arthritis-induced increase in muscular MuRF1, MAFbx, and TNF-alpha gene expression.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with adjuvant-induced arthritis, GHRP‑2 for 8 days prevented the arthritis-induced rise in muscle MAFbx gene expression.

    In plain wordsIn rats with arthritis, GHRP‑2 stopped the rise in a muscle-wasting gene called MAFbx.

    Peptide
    GHRP-2
    Outcome
    DecreaseMuscle MAFbx gene expression
    Study

    ratn: not reported in source

    adjuvant-induced arthritis
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated · 8 daysAs given in this study (rat).

    Source sentences

    Summary
    Administration of GHRP-2 for 8 days prevented the arthritis-induced increase in muscular MuRF1, MAFbx
    2 context sentences
    Summary · context
    We also studied whether the synthetic ghrelin receptor agonist, growth hormone releasing peptide-2 (GHRP-2), was able to prevent arthritis-induced changes in the skeletal muscle.
    Summary · context
    Administration of GHRP-2 for 8 days prevented the arthritis-induced increase in muscular MuRF1, MAFbx, and TNF-alpha gene expression.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with adjuvant-induced arthritis, GHRP‑2 for 8 days prevented the arthritis-induced rise in muscle TNF-alpha gene expression.

    In plain wordsIn rats with arthritis, GHRP‑2 stopped the rise in muscle TNF-alpha gene activity.

    Peptide
    GHRP-2
    Outcome
    DecreaseMuscle TNF-alpha gene expression
    Study

    ratn: not reported in source

    adjuvant-induced arthritis
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · 8 daysAs given in this study (rat).

    Source sentences

    Summary
    Administration of GHRP-2 for 8 days prevented the arthritis-induced increase in muscular MuRF1, MAFbx, and TNF-alpha gene expression.
    1 context sentence
    Summary · context
    We also studied whether the synthetic ghrelin receptor agonist, growth hormone releasing peptide-2 (GHRP-2), was able to prevent arthritis-induced changes in the skeletal muscle.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In control and arthritic rats, GHRP‑2 increased serum IGF-I concentrations.

    In plain wordsIn rats with and without arthritis, GHRP‑2 raised blood IGF-I levels.

    Peptide
    GHRP-2
    Outcome
    IncreaseSerum IGF-I concentration
    Study

    ratn: not reported in source

    adjuvant-induced arthritis
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · 8 daysAs given in this study (rat).

    Source sentences

    Summary
    GHRP-2 treatment increased the serum concentrations of IGF-I
    2 context sentences
    Summary · context
    We also studied whether the synthetic ghrelin receptor agonist, growth hormone releasing peptide-2 (GHRP-2), was able to prevent arthritis-induced changes in the skeletal muscle.
    Summary · context
    Administration of GHRP-2 for 8 days prevented the arthritis-induced increase in muscular MuRF1, MAFbx, and TNF-alpha gene expression.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In control and arthritic rats, GHRP‑2 increased IGF-I mRNA in the liver.

    In plain wordsIn rats with and without arthritis, GHRP‑2 raised IGF-I gene activity in the liver.

    Peptide
    GHRP-2
    Outcome
    IncreaseLiver IGF-I mRNA
    Study

    ratn: not reported in source

    adjuvant-induced arthritis
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · 8 daysAs given in this study (rat).

    Source sentences

    Summary
    GHRP-2 treatment increased the serum concentrations of IGF-I and the IGF-I mRNA in the liver and in the cardiac muscle and decreased muscular IGFBP-5 mRNA both in control and in arthritic rats (P < 0.05).
    2 context sentences
    Summary · context
    We also studied whether the synthetic ghrelin receptor agonist, growth hormone releasing peptide-2 (GHRP-2), was able to prevent arthritis-induced changes in the skeletal muscle.
    Summary · context
    Administration of GHRP-2 for 8 days prevented the arthritis-induced increase in muscular MuRF1, MAFbx, and TNF-alpha gene expression.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In control and arthritic rats, GHRP‑2 increased IGF-I mRNA in cardiac muscle.

    In plain wordsIn rats with and without arthritis, GHRP‑2 raised IGF-I gene activity in heart muscle.

    Peptide
    GHRP-2
    Outcome
    IncreaseCardiac muscle IGF-I mRNA
    Study

    ratn: not reported in source

    adjuvant-induced arthritis
    Outcome group
    Growth hormone and IGF-1 · Cardiovascular
    Studied dose
    Dose not stated · 8 daysAs given in this study (rat).

    Source sentences

    Summary
    GHRP-2 treatment increased the serum concentrations of IGF-I and the IGF-I mRNA in the liver and in the cardiac muscle and decreased muscular IGFBP-5 mRNA both in control and in arthritic rats (P < 0.05).
    2 context sentences
    Summary · context
    We also studied whether the synthetic ghrelin receptor agonist, growth hormone releasing peptide-2 (GHRP-2), was able to prevent arthritis-induced changes in the skeletal muscle.
    Summary · context
    Administration of GHRP-2 for 8 days prevented the arthritis-induced increase in muscular MuRF1, MAFbx, and TNF-alpha gene expression.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In control and arthritic rats, GHRP‑2 decreased IGFBP-5 mRNA in skeletal muscle.

    In plain wordsIn rats with and without arthritis, GHRP‑2 lowered IGFBP-5 gene activity in muscle.

    Peptide
    GHRP-2
    Outcome
    DecreaseSkeletal muscle IGFBP-5 mRNA
    Study

    ratn: not reported in source

    adjuvant-induced arthritis
    Outcome group
    Growth hormone and IGF-1 · Musculoskeletal
    Studied dose
    Dose not stated · 8 daysAs given in this study (rat).

    Source sentences

    Summary
    GHRP-2 treatment increased the serum concentrations of IGF-I and the IGF-I mRNA in the liver and in the cardiac muscle and decreased muscular IGFBP-5 mRNA both in control and in arthritic rats (P < 0.05).
    2 context sentences
    Summary · context
    We also studied whether the synthetic ghrelin receptor agonist, growth hormone releasing peptide-2 (GHRP-2), was able to prevent arthritis-induced changes in the skeletal muscle.
    Summary · context
    Administration of GHRP-2 for 8 days prevented the arthritis-induced increase in muscular MuRF1, MAFbx, and TNF-alpha gene expression.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In control rats, GHRP‑2 increased IGF-I mRNA in skeletal muscle.

    In plain wordsIn healthy control rats, GHRP‑2 raised IGF-I gene activity in muscle.

    Peptide
    GHRP-2
    Outcome
    IncreaseSkeletal muscle IGF-I mRNA in control rats
    Study

    ratn: not reported in source

    adjuvant-induced arthritis
    Outcome group
    Growth hormone and IGF-1 · Musculoskeletal
    Studied dose
    Dose not stated · 8 daysAs given in this study (rat).

    Source sentences

    Summary
    GHRP-2 treatment increased muscular IGF-I mRNA in control rats (P < 0.01)
    2 context sentences
    Summary · context
    We also studied whether the synthetic ghrelin receptor agonist, growth hormone releasing peptide-2 (GHRP-2), was able to prevent arthritis-induced changes in the skeletal muscle.
    Summary · context
    Administration of GHRP-2 for 8 days prevented the arthritis-induced increase in muscular MuRF1, MAFbx, and TNF-alpha gene expression.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In arthritic rats, GHRP‑2 did not change IGF-I gene expression in skeletal muscle.

    In plain wordsIn rats with arthritis, GHRP‑2 did not change IGF-I gene activity in muscle.

    Peptide
    GHRP-2
    Outcome
    No significant changeSkeletal muscle IGF-I mRNA in arthritic rats
    Study

    ratn: not reported in source

    adjuvant-induced arthritis
    Outcome group
    Growth hormone and IGF-1 · Musculoskeletal
    Studied dose
    Dose not stated · 8 daysAs given in this study (rat).

    Source sentences

    Summary
    but it did not modify the muscular IGF-I gene expression in arthritic rats.
    2 context sentences
    Summary · context
    We also studied whether the synthetic ghrelin receptor agonist, growth hormone releasing peptide-2 (GHRP-2), was able to prevent arthritis-induced changes in the skeletal muscle.
    Summary · context
    Administration of GHRP-2 for 8 days prevented the arthritis-induced increase in muscular MuRF1, MAFbx, and TNF-alpha gene expression.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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