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Study · Animal study (in vivo) · rat · 2005

6 results

Hypothalamic expression of NPY mRNA, vasopressin mRNA and CRF mRNA in response to food restriction and central administration of the orexigenic peptide GHRP-6.

Johnstone LE, Srisawat R, Kumarnsit E, Leng G

Stress (Amsterdam, Netherlands)1 Mar 2005Cited by 18 (Europe PMC)

PMID16019598 (opens in a new tab)DOI10.1080/10253890500095283 (opens in a new tab)PepBankPUB-16019598
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ad libitum-fed rats, GHRP‑6 increased food intake over 6 days.

    In plain wordsIn rats fed freely, GHRP‑6 increased food intake compared with vehicle.

    Peptide
    GHRP-6
    Outcome
    IncreaseFood intake in ad libitum-fed rats
    Study

    ratn: not reported in source

    Ad libitum-fed rats
    Comparator
    Vehicle
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricular infusion · 6 daysAs given in this study (rat).

    Source sentences

    Summary
    Ad libitum fed rats exposed to GHRP-6 increased their food intake and body weight over 6 days, but, at the end of this period, neuropeptide Y mRNA expression in the arcuate nucleus was not different to that in control rats.
    1 context sentence
    Summary · context
    We compared rats fed ad libitum with rats that were allowed food for only 2?h every day, and treated with a continuous chronic i.c.v. infusion of GHRP-6 or vehicle.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ad libitum-fed rats, GHRP‑6 increased body weight over 6 days.

    In plain wordsIn rats fed freely, GHRP‑6 increased body weight compared with vehicle.

    Peptide
    GHRP-6
    Outcome
    IncreaseBody weight in ad libitum-fed rats
    Study

    ratn: not reported in source

    Ad libitum-fed rats
    Comparator
    Vehicle
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricular infusion · 6 daysAs given in this study (rat).

    Source sentences

    Summary
    Ad libitum fed rats exposed to GHRP-6 increased their food intake and body weight over 6 days, but, at the end of this period, neuropeptide Y mRNA expression in the arcuate nucleus was not different to that in control rats.
    1 context sentence
    Summary · context
    We compared rats fed ad libitum with rats that were allowed food for only 2?h every day, and treated with a continuous chronic i.c.v. infusion of GHRP-6 or vehicle.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In ad libitum-fed rats, arcuate NPY mRNA after GHRP‑6 did not differ from controls.

    In plain wordsIn rats fed freely, GHRP‑6 did not change arcuate NPY gene expression compared with controls.

    Peptide
    GHRP-6
    Outcome
    No significant changeArcuate NPY mRNA in ad libitum-fed rats
    Study

    ratn: not reported in source

    Ad libitum-fed rats
    Comparator
    Vehicle
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricular infusion · 6 daysAs given in this study (rat).

    Source sentences

    Summary
    Ad libitum fed rats exposed to GHRP-6 increased their food intake and body weight over 6 days, but, at the end of this period, neuropeptide Y mRNA expression in the arcuate nucleus was not different to that in control rats.
    1 context sentence
    Summary · context
    We compared rats fed ad libitum with rats that were allowed food for only 2?h every day, and treated with a continuous chronic i.c.v. infusion of GHRP-6 or vehicle.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In food-restricted rats, arcuate NPY mRNA was no greater with GHRP‑6 than with vehicle.

    In plain wordsIn food-restricted rats, GHRP‑6 did not increase arcuate NPY gene expression compared with vehicle.

    Peptide
    GHRP-6
    Outcome
    No significant changeArcuate NPY mRNA in food-restricted rats
    Study

    ratn: not reported in source

    Food-restricted rats
    Comparator
    Vehicle
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricular infusionAs given in this study (rat).

    Source sentences

    Summary
    However, neuropeptide Y mRNA expression was no greater in food-restricted rats infused with GHRP-6 than in food-restricted rats infused with vehicle
    1 context sentence
    Summary · context
    We compared rats fed ad libitum with rats that were allowed food for only 2?h every day, and treated with a continuous chronic i.c.v. infusion of GHRP-6 or vehicle.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In ad libitum-fed rats, GHRP‑6 increased CRF mRNA expression.

    In plain wordsIn rats fed freely, GHRP‑6 increased CRF gene expression compared with vehicle.

    Peptide
    GHRP-6
    Outcome
    IncreaseCRF mRNA in ad libitum-fed rats
    Study

    ratn: not reported in source

    Ad libitum-fed rats
    Comparator
    Vehicle
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricular infusionAs given in this study (rat).

    Source sentences

    Summary
    GHRP-6 infusion increased CRF mRNA expression in ad libitum rats only.
    1 context sentence
    Summary · context
    We compared rats fed ad libitum with rats that were allowed food for only 2?h every day, and treated with a continuous chronic i.c.v. infusion of GHRP-6 or vehicle.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In food-restricted rats, GHRP‑6 did not increase CRF mRNA expression.

    In plain wordsIn food-restricted rats, GHRP‑6 did not increase CRF gene expression compared with vehicle.

    Peptide
    GHRP-6
    Outcome
    No significant changeCRF mRNA in food-restricted rats
    Study

    ratn: not reported in source

    Food-restricted rats
    Comparator
    Vehicle
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricular infusionAs given in this study (rat).

    Source sentences

    Summary
    GHRP-6 infusion increased CRF mRNA expression in ad libitum rats only.
    1 context sentence
    Summary · context
    We compared rats fed ad libitum with rats that were allowed food for only 2?h every day, and treated with a continuous chronic i.c.v. infusion of GHRP-6 or vehicle.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

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