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Study · Not a test of the peptide alone · 2005

3 results

Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population.

Wu S, Jia M, Ruan Y, Liu J, Guo Y, Shuang M, Gong X, Zhang Y, Yang X, Zhang D

Biological psychiatry1 Jul 2005Cited by 362 (Europe PMC)

PMID15992526 (opens in a new tab)DOI10.1016/j.biopsych.2005.03.013 (opens in a new tab)PepBankPUB-15992526
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01HumanNot a test of Oxytocin aloneObservational studyOther

    In 195 Chinese Han autism trios, two OXTR gene SNPs (rs2254298 and rs53576) were significantly associated with autism in a family-based test.

    In plain wordsIn Chinese Han families with autism, two variants of the oxytocin receptor gene were linked to autism.

    Peptide
    Oxytocin
    Outcome
    Not applicableOXTR SNP association with autism (rs2254298, rs53576)
    Study

    n = 195

    Outcome group
    Genetic association · Nervous system and cognition

    Source sentences

    Summary
    The family-based association test (FBAT) revealed a significant genetic association between autism and two of the SNPs tested (rs2254298 A: Z = 2.287, p = .0222; rs53576 A: Z = 2.573, p = .0101).
    1 context sentence
    Summary · context
    We genotyped four single nucleotide polymorphisms (SNPs) located within the OXTR gene of 195 Chinese Han autism trios, using polymerase chain reaction-restriction fragment length polymorphism analysis.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02HumanNot a test of Oxytocin aloneObservational studyOther

    In Chinese Han autism trios, several OXTR haplotypes, particularly those with rs53576, were significantly associated with autism.

    In plain wordsIn Chinese Han families with autism, combinations of oxytocin receptor gene variants, mainly with rs53576, were linked to autism.

    Peptide
    Oxytocin
    Outcome
    Not applicableOXTR haplotype association with autism (two to four markers)
    Study

    n = 195

    Outcome group
    Genetic association · Nervous system and cognition

    Source sentences

    Summary
    When haplotypes were constructed with two, three, and four markers, the haplotype-specific FBAT revealed that a number of haplotypes, particularly those involving rs53576, were significantly associated with autism.
    1 context sentence
    Summary · context
    We genotyped four single nucleotide polymorphisms (SNPs) located within the OXTR gene of 195 Chinese Han autism trios, using polymerase chain reaction-restriction fragment length polymorphism analysis.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03HumanNot a test of Oxytocin aloneObservational studyOther

    In Chinese Han autism trios, haplotypes built from all four OXTR markers showed significant excess transmission.

    In plain wordsIn Chinese Han families with autism, the full set of four oxytocin receptor gene variants was passed on more often than expected.

    Peptide
    Oxytocin
    Outcome
    Not applicableOXTR haplotype transmission with all markers
    Study

    n = 195

    Outcome group
    Genetic association · Nervous system and cognition

    Source sentences

    Summary
    Furthermore, haplotypes constructed with all markers showed a significant excess transmission for the specific and global haplotype analyses (p = .0020 and .0289, respectively).
    1 context sentence
    Summary · context
    We genotyped four single nucleotide polymorphisms (SNPs) located within the OXTR gene of 195 Chinese Han autism trios, using polymerase chain reaction-restriction fragment length polymorphism analysis.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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