Skip to content

Study · Animal study (in vivo) · mouse · 2005

4 results

Effects of long-term treatment with growth hormone-releasing peptide-2 in the GHRH knockout mouse.

Alba M, Fintini D, Bowers CY, Parlow AF, Salvatori R

American journal of physiology. Endocrinology and metabolism28 Jun 2005Cited by 13 (Europe PMC)

PMID15985453 (opens in a new tab)DOI10.1152/ajpendo.00203.2005 (opens in a new tab)PepBankPUB-15985453
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In GHRH knockout mice, chronic GHRP‑2 failed to stimulate somatotroph cell proliferation.

    In plain wordsIn mice lacking GHRH, long GHRP‑2 treatment did not make pituitary growth hormone cells multiply.

    Peptide
    GHRP-2
    Outcome
    No significant changeSomatotroph cell proliferation
    Study

    mousen: not reported in source

    GHRH knockout mice (GH deficiency)
    Comparator
    Placebo
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    10 microg twice a day · subcutaneous · 6 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Chronic treatment with GHRP-2 failed to stimulate somatotroph cell proliferation
    1 context sentence
    Summary · context
    We treated male GHRH-KO mice for 6 wk (from week 1 to week 7 of age) with GH-releasing peptide-2 (GHRP-2, 10 microg s.c. twice a day).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In GHRH knockout mice, chronic GHRP‑2 failed to stimulate GH secretion.

    In plain wordsIn mice lacking GHRH, long GHRP‑2 treatment did not raise growth hormone release.

    Peptide
    GHRP-2
    Outcome
    No significant changeGH secretion
    Study

    mousen: not reported in source

    GHRH knockout mice (GH deficiency)
    Comparator
    Placebo
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    10 microg twice a day · subcutaneous · 6 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Chronic treatment with GHRP-2 failed to stimulate somatotroph cell proliferation and GH secretion and to promote longitudinal growth.
    1 context sentence
    Summary · context
    We treated male GHRH-KO mice for 6 wk (from week 1 to week 7 of age) with GH-releasing peptide-2 (GHRP-2, 10 microg s.c. twice a day).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In GHRH knockout mice, chronic GHRP‑2 failed to promote longitudinal growth.

    In plain wordsIn mice lacking GHRH, long GHRP‑2 treatment did not make the mice grow longer.

    Peptide
    GHRP-2
    Outcome
    No significant changeLongitudinal growth
    Study

    mousen: not reported in source

    GHRH knockout mice (GH deficiency)
    Comparator
    Placebo
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    10 microg twice a day · subcutaneous · 6 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Chronic treatment with GHRP-2 failed to stimulate somatotroph cell proliferation and GH secretion and to promote longitudinal growth.
    1 context sentence
    Summary · context
    We treated male GHRH-KO mice for 6 wk (from week 1 to week 7 of age) with GH-releasing peptide-2 (GHRP-2, 10 microg s.c. twice a day).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In GHRH knockout mice, GHRP‑2 increased total body weight versus placebo, with worsening of body composition typical of GH deficiency.

    In plain wordsIn mice lacking GHRH, GHRP‑2 raised body weight compared with placebo, but body composition got worse.

    Peptide
    GHRP-2
    Outcome
    IncreaseTotal body weight
    Study

    mousen: not reported in source

    GHRH knockout mice (GH deficiency)
    Comparator
    Placebo
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    10 microg twice a day · subcutaneous · 6 weeksAs given in this study (mouse).

    Source sentences

    Summary
    GHRP-2-treated mice showed an increase in total body weight compared with placebo-treated animals, due to worsening of the body composition alterations typical of GHD animals.
    1 context sentence
    Summary · context
    We treated male GHRH-KO mice for 6 wk (from week 1 to week 7 of age) with GH-releasing peptide-2 (GHRP-2, 10 microg s.c. twice a day).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.