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Study · Non-randomized trial · n = 75 · 2005

5 results

Clinical outcome of salmon calcitonin nasal spray treatment in postmenopausal women after total hip arthroplasty.

Peichl P, Griesmacher A, Kumpan W, Schedl R, Prosquil E, Bröll H

Gerontology1 Jul 2005Cited by 19 (Europe PMC)

PMID15980653 (opens in a new tab)DOI10.1159/000085121 (opens in a new tab)PepBankPUB-15980653
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In postmenopausal women after hip arthroplasty, calcitonin significantly improved clinical outcome.

    In plain wordsIn women after hip replacement, calcitonin improved clinical outcome compared with calcium and vitamin D alone.

    Peptide
    Calcitonin-salmon
    Outcome
    IncreaseClinical outcome
    Study

    n = 75

    Comparator
    Calcium and vitamin D alone
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    200 IU twice daily in methods; 200 IU per day in results · intranasal · 12 monthsAs given in this study (human).

    Source sentences

    Summary
    The results of this 12-month clinical trial show that 200 IU of salmon calcitonin nasal spray per day significantly improves the clinical outcome of postmenopausal elderly women following THA.
    2 context sentences
    Summary · context
    In an open study, 37 women who had undergone cementless THA after accidental hip fractures were treated twice daily with 200 IU of salmon calcitonin nasal spray for 12 months.
    Summary · context
    A parallel group of 38 women with a similar clinical status in terms of hip fractures and cementless THA were treated with only one bag of 1,000 mg calcium plus 880 IU vitamin D daily through the treatment period.
  2. 02HumanNon-randomized trialEfficacy outcome

    In postmenopausal women after hip arthroplasty, calcitonin significantly reduced bone turnover, bone density loss and pain.

    In plain wordsIn women after hip replacement, calcitonin reduced bone turnover, bone density loss and pain compared with calcium and vitamin D alone.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreaseBone turnover, bone density loss and pain
    Study

    n = 75

    Comparator
    Calcium and vitamin D alone
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    200 IU twice daily in methods; 200 IU per day in results · intranasal · 12 monthsAs given in this study (human).

    Source sentences

    Summary
    Treatment with a salmon calcitonin nasal spray significantly reduces bone turnover, loss of bone density, and pain.
    2 context sentences
    Summary · context
    In an open study, 37 women who had undergone cementless THA after accidental hip fractures were treated twice daily with 200 IU of salmon calcitonin nasal spray for 12 months.
    Summary · context
    A parallel group of 38 women with a similar clinical status in terms of hip fractures and cementless THA were treated with only one bag of 1,000 mg calcium plus 880 IU vitamin D daily through the treatment period.
  3. 03HumanNon-randomized trialEfficacy outcome

    In postmenopausal women after hip arthroplasty, calcitonin promoted hip fracture repair.

    In plain wordsIn women after hip replacement, calcitonin promoted fracture repair compared with calcium and vitamin D alone.

    Peptide
    Calcitonin-salmon
    Outcome
    IncreaseHip fracture repair
    Study

    n = 75

    Comparator
    Calcium and vitamin D alone
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    200 IU twice daily in methods; 200 IU per day in results · intranasal · 12 monthsAs given in this study (human).

    Source sentences

    Summary
    Additionally, calcitonin promoted the repair of hip fractures and was associated with a significantly lesser rate of refractures as well as periprosthetic ossifications.
    2 context sentences
    Summary · context
    In an open study, 37 women who had undergone cementless THA after accidental hip fractures were treated twice daily with 200 IU of salmon calcitonin nasal spray for 12 months.
    Summary · context
    A parallel group of 38 women with a similar clinical status in terms of hip fractures and cementless THA were treated with only one bag of 1,000 mg calcium plus 880 IU vitamin D daily through the treatment period.
  4. 04HumanNon-randomized trialEfficacy outcome

    In postmenopausal women after hip arthroplasty, calcitonin was associated with significantly fewer refractures.

    In plain wordsIn women after hip replacement, calcitonin was associated with fewer repeat fractures than calcium and vitamin D alone.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreaseRefractures
    Study

    n = 75

    Comparator
    Calcium and vitamin D alone
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    200 IU twice daily in methods; 200 IU per day in results · intranasal · 12 monthsAs given in this study (human).

    Source sentences

    Summary
    Additionally, calcitonin promoted the repair of hip fractures and was associated with a significantly lesser rate of refractures as well as periprosthetic ossifications.
    2 context sentences
    Summary · context
    In an open study, 37 women who had undergone cementless THA after accidental hip fractures were treated twice daily with 200 IU of salmon calcitonin nasal spray for 12 months.
    Summary · context
    A parallel group of 38 women with a similar clinical status in terms of hip fractures and cementless THA were treated with only one bag of 1,000 mg calcium plus 880 IU vitamin D daily through the treatment period.
  5. 05HumanNon-randomized trialEfficacy outcome

    In postmenopausal women after hip arthroplasty, calcitonin was associated with significantly fewer periprosthetic ossifications.

    In plain wordsIn women after hip replacement, calcitonin was associated with less bone formation around implants than calcium and vitamin D alone.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreasePeriprosthetic ossifications
    Study

    n = 75

    Comparator
    Calcium and vitamin D alone
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    200 IU twice daily in methods; 200 IU per day in results · intranasal · 12 monthsAs given in this study (human).

    Source sentences

    Summary
    Additionally, calcitonin promoted the repair of hip fractures and was associated with a significantly lesser rate of refractures as well as periprosthetic ossifications.
    2 context sentences
    Summary · context
    In an open study, 37 women who had undergone cementless THA after accidental hip fractures were treated twice daily with 200 IU of salmon calcitonin nasal spray for 12 months.
    Summary · context
    A parallel group of 38 women with a similar clinical status in terms of hip fractures and cementless THA were treated with only one bag of 1,000 mg calcium plus 880 IU vitamin D daily through the treatment period.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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