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Study · Measured the body's own peptide · 2005

3 results

Effects of cholecystokinin (CCK)-8 on hypothalamic oxytocin-secreting neurons in rats lacking CCK-A receptor.

Hashimoto H, Onaka T, Kawasaki M, Chen L, Mera T, Soya A, Saito T, Fujihara H, Sei H, Morita Y, Ueta Y

Autonomic neuroscience : basic & clinical1 Aug 2005Cited by 22 (Europe PMC)

PMID15979947 (opens in a new tab)DOI10.1016/j.autneu.2005.05.002 (opens in a new tab)PepBankPUB-15979947
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In OLETF rats that lack the CCK-A receptor, intravenous CCK-8 did not change plasma oxytocin.

    In plain wordsIn rats without the CCK-A receptor, CCK-8 did not change the body's own oxytocin level in blood.

    Peptide
    Oxytocin
    Outcome
    No significant changePlasma oxytocin after CCK-8 in CCK-A receptor deficient OLETF rats
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Radioimmunoassay for OXT and arginine vasopressin (AVP) showed that iv administration of CCK-8 did not cause significant change in the plasma OXT and AVP levels in OLETF rats, while iv administration of CCK-8 caused a significant elevation of plasma OXT level without changing the plasma AVP level in LETO rats.
    1 context sentence
    Summary · context
    We examined the effects of intravenous (iv) administration of CCK-8 on the neuronal activity of hypothalamic OXT-secreting neurons and plasma OXT level in Otsuka Long-Evans Tokushima Fatty (OLETF) rats that have a congenital defect in the expression of the CCK-A receptor gene.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In control LETO rats, intravenous CCK-8 raised plasma oxytocin without changing plasma vasopressin.

    In plain wordsIn control rats, CCK-8 raised the body's own oxytocin level in blood.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma oxytocin after CCK-8 in control LETO rats
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Radioimmunoassay for OXT and arginine vasopressin (AVP) showed that iv administration of CCK-8 did not cause significant change in the plasma OXT and AVP levels in OLETF rats, while iv administration of CCK-8 caused a significant elevation of plasma OXT level without changing the plasma AVP level in LETO rats.
    1 context sentence
    Summary · context
    We examined the effects of intravenous (iv) administration of CCK-8 on the neuronal activity of hypothalamic OXT-secreting neurons and plasma OXT level in Otsuka Long-Evans Tokushima Fatty (OLETF) rats that have a congenital defect in the expression of the CCK-A receptor gene.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In control LETO rats, intravenous CCK-8 induced Fos mainly in oxytocin-secreting neurons of the supraoptic and paraventricular nuclei.

    In plain wordsIn control rats, CCK-8 activated the body's own oxytocin-making brain cells.

    Peptide
    Oxytocin
    Outcome
    IncreaseFos in oxytocin-secreting neurons after CCK-8 in LETO rats
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Dual immunostaining for OXT and Fos revealed that Fos-LI was mainly observed in OXT-secreting neurons in the SON and the PVN of LETO rats 90 min after iv administration of CCK-8 (20 microg/kg).
    1 context sentence
    Summary · context
    We examined the effects of intravenous (iv) administration of CCK-8 on the neuronal activity of hypothalamic OXT-secreting neurons and plasma OXT level in Otsuka Long-Evans Tokushima Fatty (OLETF) rats that have a congenital defect in the expression of the CCK-A receptor gene.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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