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Study · Animal study (in vivo) · mouse · 2005

2 results

Effects of melanocortin receptor activation and blockade on ethanol intake: a possible role for the melanocortin-4 receptor.

Navarro M, Cubero I, Chen AS, Chen HY, Knapp DJ, Breese GR, Marsh DJ, Thiele TE

Alcoholism, clinical and experimental research1 Jun 2005Cited by 45 (Europe PMC)

PMID15976520 (opens in a new tab)PMCIDPMC1360238 (opens in a new tab)DOI10.1097/01.alc.0000167740.19702.8c (opens in a new tab)PepBankPUB-15976520
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Mc3r-deficient and wild-type mice, melanotan II reduced ethanol drinking to a similar extent.

    In plain wordsIn mice, melanotan II reduced alcohol drinking, and it worked as well in mice lacking the MC3 receptor as in normal mice.

    Peptide
    Melanotan II
    Outcome
    DecreaseEthanol drinking in Mc3r-deficient and wild-type mice
    Study

    mousen: not reported in source

    Mc3r-deficient and wild-type littermate mice
    Comparator
    Wild-type littermate mice
    Outcome group
    Addiction, withdrawal and alcohol intake · Nervous system and cognition
    Studied dose
    10 mg/kg intraperitoneal; 1.0 microg intracerebroventricular · intraperitoneal; intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    MTII was similarly effective at reducing ethanol drinking in Mc3r-deficient (Mc3r) and wild-type (Mc3r) littermate mice.
    1 context sentence
    Summary · context
    Mc3r-deficient (Mc3r) and wild-type (Mc3r) littermate mice were given intraperitoneal (10 mg/kg) and intracerebroventricular (1.0 microg ICV) doses of melanotan II (MTII), a nonselective MCR agonist.
  2. 02AnimalAnimal study (in vivo)Other

    In mice, melanotan II did not alter blood ethanol levels at doses that modulated ethanol drinking.

    In plain wordsIn mice, melanotan II did not change blood alcohol levels at doses that changed alcohol drinking.

    Peptide
    Melanotan II
    Outcome
    No significant changeBlood ethanol levels
    Study

    mousen: not reported in source

    Mice
    Outcome group
    Addiction, withdrawal and alcohol intake · Nervous system and cognition
    Studied dose
    10 mg/kg intraperitoneal; 1.0 microg intracerebroventricular · intraperitoneal; intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    Neither MTII nor AgRP-(83-132) altered blood ethanol levels at doses that modulated ethanol drinking.
    1 context sentence
    Summary · context
    Mc3r-deficient (Mc3r) and wild-type (Mc3r) littermate mice were given intraperitoneal (10 mg/kg) and intracerebroventricular (1.0 microg ICV) doses of melanotan II (MTII), a nonselective MCR agonist.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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