Skip to content

Study · Animal study (in vivo) · rat · 2005

3 results

Oxytocin increases the density of high affinity alpha(2)-adrenoceptors within the hypothalamus, the amygdala and the nucleus of the solitary tract in ovariectomized rats.

Petersson M, Diaz-Cabiale Z, Diaz-Cabiale Z, Angel Narváez J, Fuxe K, Uvnäs-Moberg K

Brain research1 Jul 2005Cited by 25 (Europe PMC)

PMID15967417 (opens in a new tab)DOI10.1016/j.brainres.2005.05.034 (opens in a new tab)PepBankPUB-15967417
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In ovariectomized female rats, oxytocin increased the density of high affinity alpha(2)-adrenoceptor binding sites in the hypothalamus, amygdala and nucleus of the solitary tract.

    In plain wordsIn rats, oxytocin increased the number of alpha-2 adrenoceptor binding sites in three brain areas compared with saline.

    Peptide
    Oxytocin
    Outcome
    Increasealpha(2)-adrenoceptor agonist binding site density (Bmax)
    Study

    ratn: not reported in source

    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    1 mg/kg · subcutaneous · 10 daysAs given in this study (rat).

    Source sentences

    Summary
    Oxytocin increased the B(max) values of the alpha(2)-adrenoceptor agonist [3H]UK14.304 binding sites significantly in all the analyzed areas (P<0.05).
    1 context sentence
    Summary · context
    For this purpose, female ovariectomized (OVX) rats were treated with oxytocin (1 mg/kg s.c.) or saline once a day for 10 days.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In ovariectomized female rats, oxytocin did not change the Kd of alpha(2)-adrenoceptor agonist binding.

    In plain wordsIn rats, oxytocin did not change how tightly the alpha-2 adrenoceptor bound its agonist.

    Peptide
    Oxytocin
    Outcome
    No significant changealpha(2)-adrenoceptor agonist binding affinity (Kd)
    Study

    ratn: not reported in source

    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    1 mg/kg · subcutaneous · 10 daysAs given in this study (rat).

    Source sentences

    Summary
    K(d) values were unchanged.
    1 context sentence
    Summary · context
    For this purpose, female ovariectomized (OVX) rats were treated with oxytocin (1 mg/kg s.c.) or saline once a day for 10 days.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In ovariectomized female rats, oxytocin decreased plasma corticosterone compared with saline.

    In plain wordsIn rats, oxytocin lowered the stress hormone corticosterone in blood compared with saline.

    Peptide
    Oxytocin
    Outcome
    DecreasePlasma corticosterone
    Study

    ratn: not reported in source

    Comparator
    Saline
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    1 mg/kg · subcutaneous · 10 daysAs given in this study (rat).

    Source sentences

    Summary
    Plasma levels of corticosterone were significantly decreased in the oxytocin-treated rats (P<0.05).
    1 context sentence
    Summary · context
    For this purpose, female ovariectomized (OVX) rats were treated with oxytocin (1 mg/kg s.c.) or saline once a day for 10 days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.