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Study · Animal study (in vivo) · goat · 2005

4 results

Activation of melanocortin receptors accelerates the gonadotropin-releasing hormone pulse generator activity in goats.

Matsuyama S, Ohkura S, Sakurai K, Tsukamura H, Maeda K, Okamura H

Neuroscience letters1 Aug 2005Cited by 11 (Europe PMC)

PMID15955423 (opens in a new tab)DOI10.1016/j.neulet.2005.04.026 (opens in a new tab)PepBankPUB-15955423
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized goats, all doses of MT II injected into the lateral ventricle shortened the intervals between MUA volleys of the GnRH pulse generator.

    In plain wordsIn goats, MT II given into the brain sped up the activity of the GnRH pulse generator at all tested doses.

    Peptide
    Melanotan II
    Outcome
    DecreaseMUA volley interval (GnRH pulse generator activity)
    Study

    goatn: not reported in source

    ovariectomized goats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    0.02, 0.2 and 2 nmol · intracerebroventricular (lateral ventricle)As given in this study (goat).

    Source sentences

    Summary
    In ovariectomized goats, all doses (0.02, 0.2 and 2 nmol) of MT II, an MC3/4-R agonist, injected into the lateral ventricle significantly shortened MUA volley intervals.
    1 context sentence
    Summary · context
    The present study aims to elucidate whether the central melanocortin receptors [melanocortin-3 and -4 receptors (MC3/4-R)] are involved in regulating GnRH pulse generator activity in female goats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized goats, the duration of MUA volley acceleration by MT II was positively correlated with the MT II dose.

    In plain wordsIn goats, higher MT II doses sped up the GnRH pulse generator for longer.

    Peptide
    Melanotan II
    Outcome
    IncreaseDuration of MT II acceleration of MUA volleys versus dose
    Study

    goatn: not reported in source

    ovariectomized goats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    0.02, 0.2 and 2 nmol · intracerebroventricular (lateral ventricle)As given in this study (goat).

    Source sentences

    Summary
    The duration of the period during which MT II accelerated MUA volleys was positively correlated with the dose of MT II injected.
    1 context sentence
    Summary · context
    The present study aims to elucidate whether the central melanocortin receptors [melanocortin-3 and -4 receptors (MC3/4-R)] are involved in regulating GnRH pulse generator activity in female goats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized goats, the stimulatory effect of MT II on GnRH pulse generator activity was attenuated in the presence of estrogen.

    In plain wordsIn goats, estrogen weakened the speeding-up effect of MT II on the GnRH pulse generator.

    Peptide
    Melanotan II
    Outcome
    DecreaseMT II effect on GnRH pulse generator activity with estrogen
    Study

    goatn: not reported in source

    ovariectomized goats
    Comparator
    Without estrogen
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The stimulatory effect of MT II on the GnRH pulse generator activity was attenuated in the presence of estrogen.
    1 context sentence
    Summary · context
    The present study aims to elucidate whether the central melanocortin receptors [melanocortin-3 and -4 receptors (MC3/4-R)] are involved in regulating GnRH pulse generator activity in female goats.

Studies that did not test the peptide alone1

In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan II.

  1. 04AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Mechanism

    In ovariectomized goats, pre-administered SHU9119 at 1 nmol partially blocked the acceleration of MUA volleys induced by 0.2 nmol MT II.

    In plain wordsIn goats, the receptor blocker SHU9119 partly stopped MT II from speeding up the GnRH pulse generator.

    Peptide
    Melanotan II
    Outcome
    DecreaseBlockade of MT II-induced MUA volley acceleration by SHU9119
    Study

    goatn: not reported in source

    ovariectomized goats
    Comparator
    MT II without SHU9119
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    MT II (0.2 nmol)-induced acceleration of MUA volleys was partially blocked by the antagonism of MC3/4-R with pre-administered SHU9119 (1 nmol).
    1 context sentence
    Summary · context
    The present study aims to elucidate whether the central melanocortin receptors [melanocortin-3 and -4 receptors (MC3/4-R)] are involved in regulating GnRH pulse generator activity in female goats.

    In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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