Effects of growth hormone secretagogues on the release of adenohypophyseal hormones in young and old healthy dogs.

Bhatti SF, Duchateau L, Van Ham LM, De Vliegher SP, Mol JA, Rijnberk A, Kooistra HS

Veterinary journal (London, England : 1997)13 Jun 2005Cited by 10 (Europe PMC)

PMID15951209DOI10.1016/j.tvjl.2005.04.025PepBankPUB-15951209

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

2 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Activity measurement
In Beagle dogs, GHRP‑6 elicited a lower mean GH concentration in old dogs than young dogs, without statistical significance.
In plain wordsIn dogs, the GH response to GHRP‑6 did not differ significantly between old and young dogs.
Peptide
GHRP-6
Outcome
No significant changeGH response by age
Study
Beagle dogsn: not reported in source
Young and old healthy dogs
Comparator
Young dogs
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
The mean plasma GH concentration after GHRH and GHRP-6 administration was lower in the old dogs compared with the young dogs, but this difference did not reach statistical significance.
Report a problemFND-1595120901
02AnimalAnimal study (in vivo)Activity measurement
In young healthy Beagle dogs, GHRP‑6 stimulated GH release less strongly than ghrelin.
In plain wordsIn young dogs, GHRP‑6 stimulated less GH release than ghrelin.
Peptide
GHRP-6
Outcome
DecreaseGH response versus ghrelin in young dogs
Study
Beagle dogsn: not reported in source
Young healthy dogs
Comparator
Ghrelin
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
Ghrelin proved to be the most potent GHS in young dogs, whereas in old dogs GHRH administration was associated with the highest plasma GH concentrations.
1 context sentence(design, population, supporting numbers)
Summary · context
were investigated in young and old healthy Beagle dogs.
Report a problemFND-1595120907

Studies that did not test the peptide alone5

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

03AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Activity measurement
In young and old dogs, the tested GHSs, including GHRP‑6, did not significantly elevate plasma ACTH.
In plain wordsIn dogs, the tested secretagogues, including GHRP‑6, did not significantly raise ACTH.
Peptide
GHRP-6
Outcome
No significant changeACTH response
Study
Beagle dogsn: not reported in source
Young and old healthy dogs
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
In both age groups, the GHSs were specific for GH release as they did not cause significant elevations in the plasma concentrations of ACTH, cortisol, TSH, LH, and PRL.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-1595120902
04AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Activity measurement
In young and old dogs, the tested GHSs, including GHRP‑6, did not significantly elevate plasma cortisol.
In plain wordsIn dogs, the tested secretagogues, including GHRP‑6, did not significantly raise cortisol.
Peptide
GHRP-6
Outcome
No significant changeCortisol response
Study
Beagle dogsn: not reported in source
Young and old healthy dogs
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
In both age groups, the GHSs were specific for GH release as they did not cause significant elevations in the plasma concentrations of ACTH, cortisol, TSH, LH, and PRL.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-1595120903
05AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Activity measurement
In young and old dogs, the tested GHSs, including GHRP‑6, did not significantly elevate plasma TSH.
In plain wordsIn dogs, the tested secretagogues, including GHRP‑6, did not significantly raise TSH.
Peptide
GHRP-6
Outcome
No significant changeTSH response
Study
Beagle dogsn: not reported in source
Young and old healthy dogs
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
In both age groups, the GHSs were specific for GH release as they did not cause significant elevations in the plasma concentrations of ACTH, cortisol, TSH, LH, and PRL.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-1595120904
06AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Activity measurement
In young and old dogs, the tested GHSs, including GHRP‑6, did not significantly elevate plasma LH.
In plain wordsIn dogs, the tested secretagogues, including GHRP‑6, did not significantly raise LH.
Peptide
GHRP-6
Outcome
No significant changeLH response
Study
Beagle dogsn: not reported in source
Young and old healthy dogs
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
In both age groups, the GHSs were specific for GH release as they did not cause significant elevations in the plasma concentrations of ACTH, cortisol, TSH, LH, and PRL.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-1595120905
07AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Activity measurement
In young and old dogs, the tested GHSs, including GHRP‑6, did not significantly elevate plasma PRL.
In plain wordsIn dogs, the tested secretagogues, including GHRP‑6, did not significantly raise prolactin.
Peptide
GHRP-6
Outcome
No significant changePRL response
Study
Beagle dogsn: not reported in source
Young and old healthy dogs
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
In both age groups, the GHSs were specific for GH release as they did not cause significant elevations in the plasma concentrations of ACTH, cortisol, TSH, LH, and PRL.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-1595120906

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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