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Study · Animal study (in vivo) · squirrel monkey · 2005

2 results

Intranasal oxytocin administration attenuates the ACTH stress response in monkeys.

Parker KJ, Buckmaster CL, Schatzberg AF, Lyons DM

Psychoneuroendocrinology1 Oct 2005Cited by 141 (Europe PMC)

PMID15946803 (opens in a new tab)DOI10.1016/j.psyneuen.2005.04.002 (opens in a new tab)PepBankPUB-15946803
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adult female squirrel monkeys, chronic intranasal oxytocin gave lower ACTH concentrations than saline after 90 minutes of social isolation.

    In plain wordsIn squirrel monkeys, oxytocin sprayed into the nose gave lower stress hormone ACTH than saline after social isolation.

    Peptide
    Oxytocin
    Outcome
    DecreaseACTH concentration after 90 min of social isolation
    Study

    squirrel monkeyn: not reported in source

    Comparator
    Saline
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    50 microg · intranasal · 8 daysAs given in this study (squirrel monkey).

    Source sentences

    Summary
    Consistent with an anti-stress effect, OT-treated monkeys exhibited lower ACTH concentrations compared to saline-treated monkeys after 90 min of social isolation (F(1,7) = 6.891; P = 0.034).
    2 context sentences
    Summary · context
    This experiment investigated the effects of chronic intranasal OT administration on acute stress-induced hypothalamic-pituitary-adrenal (HPA) axis activation in adult female squirrel monkeys.
    Summary · context
    Monkeys were intranasally administered either 50 microg oxytocin (N = 6 monkeys) or 0 microg oxytocin (N = 6 monkeys)/300 microl saline once a day for eight consecutive days.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In adult female squirrel monkeys, intranasal oxytocin did not change cortisol concentrations compared with saline.

    In plain wordsIn squirrel monkeys, oxytocin sprayed into the nose did not change cortisol compared with saline.

    Peptide
    Oxytocin
    Outcome
    No significant changeCortisol concentration during social isolation
    Study

    squirrel monkeyn: not reported in source

    Comparator
    Saline
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    50 microg · intranasal · 8 daysAs given in this study (squirrel monkey).

    Source sentences

    Summary
    No drug-related differences in cortisol levels were observed, indicating that OT does not directly attenuate the adrenal stress response.
    2 context sentences
    Summary · context
    This experiment investigated the effects of chronic intranasal OT administration on acute stress-induced hypothalamic-pituitary-adrenal (HPA) axis activation in adult female squirrel monkeys.
    Summary · context
    Monkeys were intranasally administered either 50 microg oxytocin (N = 6 monkeys) or 0 microg oxytocin (N = 6 monkeys)/300 microl saline once a day for eight consecutive days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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