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Study · In vitro (cells) · candida spp. · 2005

2 results

Three-dimensional structure of the alpha-MSH-derived candidacidal peptide [Ac-CKPV]2.

Catania A, Grieco P, Randazzo A, Novellino E, Gatti S, Rossi C, Colombo G, Lipton JM

The journal of peptide research : official journal of the American Peptide Society1 Jul 2005Cited by 14 (Europe PMC)

PMID15946192 (opens in a new tab)DOI10.1111/j.1399-3011.2005.00265.x (opens in a new tab)PepBankPUB-15946192
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    The KPV dimer [Ac-CKPV]2 was active against azole-resistant Candida species in vitro.

    In plain wordsIn lab tests, a dimer made of two KPV units was active against azole-resistant Candida fungi.

    Peptide
    KPV
    Outcome
    Not applicableActivity of [Ac-CKPV]2 against azole-resistant Candida
    Study

    Candida spp.n: not reported in source

    azole-resistant Candida spp.
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    [Ac-CKPV]2 was active against azole-resistant Candida spp.
    1 context sentence
    Summary · context
    we designed the dimer [Ac-CKPV]2

Studies that did not test the peptide alone1

In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking KPV.

  1. 02LabNot a test of KPV aloneIn vitro (cell-free)Other

    NMR and restrained mechanics and dynamics calculations suggest that the KPV dimer [Ac-CKPV]2 has an extended backbone with a beta-turn-like structure.

    In plain wordsIn lab and computer analysis, a dimer made of two KPV units appeared to have an extended backbone with a beta-turn-like shape.

    Peptide
    KPV
    Outcome
    Not applicableThree-dimensional structure of [Ac-CKPV]2
    Study

    n: not reported in source

    NMR and molecular modelling
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    1H-NMR and restrained mechanic and dynamic calculations suggest that the peptide adopts an extended backbone structure with a beta-turn-like structure.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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